教育背景

1991~1996 天津医科大学 临床医学学士

1998~2001 天津医科大学 医学硕士

2005~2008 首都医科大学 医学博士

工作经历

1996~2001 天津医科大学 助教

2001~2005 天津医科大学 讲师

2008~2011 中国科学院动物研究所 博士后

2011~2017 清华大学医学院 讲师

2017~2024 清华大学医学院 副教授

2018~2019 美国匹兹堡大学 访问学者

2024-至今 清华大学基础医学院 副教授

研究领域

细胞信号转导、神经退行性病变

代表性论文

1.Guangchao Gu, Jinping Liu, Yanze Lv, Hui Huang, Fangda Li, Mengyin Chen, Yuexin Chen, Jiang Shao, Bao Liu, Changwei Liu, Xiaodong Zhang, Yuehong Zheng. Costoclavicular Ligament as a Novel Cause of Venous Thoracic Outlet Syndrome: From Anatomic Study to Clinical Application. Surg Radiol Anat. 2020 Aug;42(8):865-870.

2.Liu J, Chang L, Song Y, Li H, Wu Y. The Role of NMDA Receptors in Alzheimer's Disease. Front Neurosci. 2019, 13: 43.

3.Lv L, Liu J, Du Z, Song Y, Li H, Li X, Chang L, Wu Y. Expression alterations of apoptosis repressor with caspase recruitment domain in Abeta(25-35)-induced hippocampal neurotoxicity. Neuroreport. 2019, 30(1):1-7.

4.Su D, Liu H, Liu T, Zhang X, Yang W, Song Y, Liu J, Wu Y, Chang L. Dynamic SAP102 expression in the hippocampal subregions of rats and APP/PS1 mice of various ages. J Anat. 2018, 232(6):987-996.

5.Fang Y^#, Li H^#, Chang L, Song Y, Ma L, Lu L, Du Z, Li Y, Liu J, Wu Y. Prenatal stress induced gender-specific alterations of N-methyl-D-aspartate receptor subunit expression and response to Aβ in offspring hippocampal cells. Behav Brain Res. 2018, 336:182-190.

6.Chang L, Zhang Y, Liu J, Song Y, Lv A, Li Y, Zhou W, Yan Z, Almeida OF, Wu Y. Differential Regulation of N-Methyl-D-Aspartate Receptor Subunits is an Early Event in the Actions of Soluble Amyloid-beta (1-40) Oligomers on Hippocampal Neurons, J Alzheimers Dis. 2016, 51(1): 197-212.

7.Li Y^#, Chang L^#, Song Y, Gao X, Roselli F, Liu J, Zhou W, Fang Y, Ling W, Li H, Almeida OF, Wu Y. Astrocytic GluN2A and GluN2B Oppose the Synaptotoxic Effects of Amyloid-beta1-40 in Hippocampal Cells, J Alzheimers Dis. 2016, 54(1): 135-148.

8.Lu D^#, Liu J^#, JiaoJ, Long B, Li Q, Tan W, Li P. Foxo3a prevents apoptosis by regulating calcium through the apoptosis repressor with caspase recruitment domain, J Biol Chem. 2013, 288(12): 8491-8504.

9.Zhou LY, Liu JP, Wang K, Gao J, Ding SL, Jiao JQ, Li PF. Mitochondrial function in cardiac hypertrophy, Int J Cardiol. 2013, 167(4): 1118-1125.

10.Wang K, Long B, Jiao JQ, Wang JX, Liu JP, Li Q, Li PF. miR-484 regulates mitochondrial network through targeting Fis1, Nat Commun. 2012, 3: 781.

11.Wang JX, Jiao JQ, Li Q, Long B, Wang K, Liu JP, Li YR, Li PF. miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1, Nat Med. 2011, 17(1): 71-78.

12.Chang LR^#, Liu JP^#, Song YZ, Lu Tao, Lu G, Wu Y. Expression of caspase-8 and caspase-9 in rat hippocampus during postnatal development, Microsc Res Tech. 2011, 74(2): 153-158.

13.Liu J, Chang L, Roselli F, Almeida OFX, GaoX , Wang X, Yew DT, Wu Y. Aβ induces caspase-dependent loss of PSD-95 and synaptophysin through NMDA receptors, J Alzheimers Dis. 2010, 22(2): 541-556.

14.Liu JP, Chang LR, Gao XL, Wu Y. Different expression of caspase-3 in rat hippocampal subregions during postnatal development, Microsc Res Tech. 2008, 1(9): 633-638.