教育背景
2011-2014 厦门大学国家传染病诊断试剂与疫苗工程技术研究中心 硕士
2014-2019 清华大学生命科学学院 博士
工作经历
2019-2021 清华大学医学院 博士后
2021-2024 清华大学医学院 助理研究员
2024-至今 清华大学基础医学院 副研究员
研究领域
蚊媒病毒是一类由蚊等媒介节肢动物携带并传播给人类及动物的病毒。近年来，寨卡病毒，基肯孔雅病毒，登革病毒等烈性蚊媒病毒对全球公共卫生安全造成严重威胁。蚊媒病毒通过“宿主-病毒-蚊媒”建立病毒传播循环，其传播及感染致病的分子机制仍未得到完全阐明，因此深入理解“宿主-病毒-蚊媒”三者的互作关系，将为蚊媒病毒防控提供重要生物学基础和策略。
科学贡献
首次发现并报道一种全新的天然定植于伊蚊肠道的共生菌可阻断蚊媒病毒传播，该项研究为登革热的生物防治提供了极具潜力的防控策略 (Science 2024)；揭示蚊媒病毒快速传播的分子机制，提出一种基于皮肤微生物调控的蚊媒病毒防治策略 (Cell 2022)；系统阐明病毒劫持多种宿主血液因子促进病毒感染媒介伊蚊的分子机制 (Cell Reports 2021, Nature Microbiology 2019, Nature Communications 2017)，以上工作为蚊媒病毒由伊蚊传播的分子机制提供了证据。相关研究成果受到Cell, Science, Nature等国际期刊的亮点评述或报道，受到美国微生物学会-每周病毒学 (This Week in Virology, TWiV) 专栏重点评述 (两次)。研究成果入选2022年度中国重要医学进展，Cell Press 中国年度论文。
荣誉奖励
2024 《麻省理工科技评论》-35岁以下科技创新35人(亚太区)
2024 国家优秀青年科学基金
2023 中国昆虫学会青年科学技术奖
2023 教育部自然科学奖一等奖 (第六完成人)
2021 第七届中国科协青年人才托举工程
2020 北京市科学技术奖自然科学奖一等奖（第三完成人）
代表性论文
1.Zhang LM*, Wang DX*, Shi PB, Li JZ, Niu JC, Chen JL, Wang G, Wu LJ, Chen L, Yang ZX, Li SS, Meng JX, Ruan FC, He YW, Zhao HL, Ren ZR, Wang YB, Liu Y, Shi XL, Wang YF, Liu QY, Li JH, Wang PH, Wang JL#, Zhu YB#, Cheng G#. A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes. Science. 2024, 384: eadn9524. (*equal authorship, #co-corresponding author) News by Science, Research Highlighted by Nature Reviews Microbiology, Spotlight by Trends in Microbiology
2.Zhang H*, Zhu YB*, Liu ZW, Peng YM, Peng WY, Tong LQ, Wang JL, Liu QY, Wang PH, Cheng G #. (2022) A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness. Cell. 185: 2510–2522. (*equal authorship, #co-corresponding author) Preview by Cell, News by Science and Nature, Research Highlighted by Nature Reviews Microbiology and Cell Research, Highlighted by TiWV919: Motivated by volatiles.
3.Zhu YB, Zhang C; Zhang LM; Yu X; Yang Y; Liu QY; Wang PH; Cheng G#. A human blood-derived microRNA facilitates flavivirus infection in fed mosquitoes. Cell Reports. 2021, 37: 110091. Spotlight by Trends in Parasitology.
4.Zhu YB, Tong LQ, Nie KX, Itsanun Wiwatanaratanabutr, Sun P, Li QQ, Yu X, Wu P, Wu TS, Yu C, Liu QY, Bian ZQ, Wang PH, Cheng G#. Host serum iron modulates dengue virus acquisition by mosquitoes. Nature Microbiology. 2019, 4: 2405-2415. Highlighted by TWiV 569: Smolt’in iron.
5.Zhu YB, Zhang RD, Zhang B, Zhao TY, Wang PH, Liang GD, Cheng G#. Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system. Nature Communications. 2017, 8: 1262
6.Zhu YB#, Cheng G#. Making hosts smell tastier: How mosquito-borne viruses take the initiative in viral transmission, Clinical and Translational Medicine, 2023, 13: e1168. (#co-corresponding author)
7.Zhu YB*, Liu JY*, Cheng G#. (2023) Progress towards research on mosquito-borne arboviral transmission and infection. Science Bulletin, 68, 2884-2888. (*equal authorship)
8.Zhu YB*#, Yu X*, Jiang LP, Wang Y, Shi XL, Cheng G#. (2023) Advances in research on arboviral acquisition from hosts to mosquitoes. Current Opinion in Insect Science, 61, 101141. (*equal authorship, #co-corresponding author)
9.Ma EH, Zhu YB, Liu ZW, Wei TY, Wang PH, Cheng G. Interaction of viruses with the insect intestine. Annu Rev Virol. 2021, 8: 115-131.
10.Yu X*, Zhu YB*, Xiao XP*, Wang PH, Cheng G#. Progress towards understanding the mosquito-borne virus life cycle. Trends in Parasitology. 2019, 35: 1009-1017 (*equal authorship.)
