教育背景
1989-1994 潍坊医学院临床医学 学士
1994-1997 第二军医大学免疫学研究所 硕士
1999-2002 第二军医大学免疫学研究所 博士
工作经历
1997-1999 第二军医大学免疫学教研室 助教
1999-2004 第二军医大学免疫学研究所 讲师
2004-2005 清华大学医学院 博士后
2005-2024 清华大学医学院 副教授 2024-至今 清华大学基础医学院 副教授
研究领域
肿瘤免疫学。本实验室主要围绕细胞免疫学的基础研究及肿瘤的免疫学治疗方法开展研究。免疫微环境可以转变免疫细胞的功能状态，让激活性树突状细胞转化为抑制性树突状细胞，这是免疫应答平息的主动调节机制，并进一步通过研究抑制性树突状细胞探索其对自身免疫性疾病治疗的潜在意义。自2005年主要研究方向集中在CD8+NKT的生物学功能研究和应用研究。CD8+NKT细胞是具有抗原特异性和非特异性双重抗肿瘤作用的细胞亚群，通过开展多项临床研究，探索其在肺癌、肝癌、黑色素瘤等多种实体肿瘤的治疗作用。
科学贡献
发现了成熟树突状细胞可以在免疫微环境中增殖再分化；在国际上率先建立了NKT的大规模扩增方法，发现了NKT的双向抗肿瘤效应。创立了基于NKT的新一代抗肿瘤免疫细胞治疗技术，该研究是“十二五重大新药创制计划”支持的唯一细胞治疗项目，并获得美国专利授权。目前在北京大学肿瘤医院、长海医院、东方肝胆医院、江苏大学附属医院、齐鲁大学南山分院开展临床研究，累积案例近700例，用于治疗肺癌、肝癌、黑色素瘤等多种实体肿瘤。以第一作者和通讯作者在Nature Immunology、Blood、Scientific Reports等免疫学高水平杂志发表文章；主持、参加多项自然科学基金、十二五国家新药创制计划、重大传染病计划以及“863”计划等国家项目。
荣誉奖励
2020 人民网“年度科普达人”和“年度科普红人”
2018《健康报》“年度最受医生欢迎文章”奖
2009 清华大学第八届良师益友
2006 中华医学科技奖一等奖
2006上海市医学科技奖 一等奖
2005 全国优秀博士学位论文（第一完成人）
2004 中国高等院校10大科技进展
代表性论文及专利
1.Wang, Q., S. Chen, Z.Guo, S. Xia and M. Zhang*.(2024) NK-like CD8 T cell: one potential evolutionary continuum between adaptive memory and innate immunity. Clin Exp Immunol, 217(2):136-150.
2.Yu, W., X. Yuan, F. Ye, C. Mao, J. Li, M. Zhang, D.Chen and S. Xia. (2022). Role of allogeneic natural killer T cells in the treatment of a patient with gefitinib-sensitive lung adenocarcinoma. Immunotherapy, 14(16):1291-1296.
3.Yu, W., F. Ye, X. Yuan, Y. Ma, C. Mao, X. Li , J. Li, C. Dai, F. Qian, J. Li, X. Fan, Y. Zhou, D. Wang, Z. Guo, H. An, M. Zhang, D. Chen and S. Xia.A (2021) phase I/II clinical trial on the efficacy and safety of NKT cells combined with gefitinib for advanced EGFR-mutated non-small-cell lung cancer. BMC Cancer, 21(1):877.
4.Li, Z., Y. Wu, C. Wang and M. Zhang*. (2019). "Mouse CD8(+)NKT-like cells exert dual cytotoxicity against mouse tumor cells and myeloid-derived suppressor cells." Cancer Immunol Immunother 68(8): 1303-1315.
5.Wang, C., Z. Li, Z. Zhu, Y. Chai, Y. Wu, Z. Yuan, Z. Chang, Z. Wang and M. Zhang *.(2019). Allogeneic dendritic cells induce potent antitumor immunity by activating KLRG1(+)CD8 T cells. Sci Rep 9(1): 15527.
6.Ma, H., Chen, S., He, Y., Huang, J., Xu, Y., Wang, C., Lei, C., Lu, T., Xiao, S., Mao, J., Xu, Y., Guo, H., Li, B., M. Zhang and He, X*. (2018). Redirecting T cells to glypican-3 with 28.41BB.ζ and 28.ζ-41BBL CARs for hepatocellular carcinoma treatment. Protein & cell, 9(7), 664–669.
7.M. Zhang*.（2018）. Adoptive cell transfer therapy: A strategic rethinking of combination cancer therapy. Science SUPPLEMENT. Precision medicine and cancer immunology in China.52-56.
8.Zhao, L., Yang, G., Bai, H., M. Zhang and Mou, D. (2017). NCTD promotes Birinapant-mediated anticancer activity in breast cancer cells by downregulation of c-FLIP. Oncotarget, 8(16), 26886–26895.
9.Chen, D., Y. Wang, H. Wang, Y. Wu, S. Xia and M. Zhang*. (2015). "CD8(+) T activation attenuates CD4(+) T proliferation through dendritic cells modification." Cell Immunol 296(2): 138-148.
10.Wang, C., X. Liu, Z. Li, Y. Chai, Y. Jiang, Q. Wang, Y. Ji, Z. Zhu, Y. Wan, Z. Yuan, Z. Chang and M. Zhang *.(2015). "CD8(+)NKT-like cells regulate the immune response by killing antigen-bearing DCs." Sci Rep 5: 14124.
11.Xia, S*., X. Li, L. Cheng, M. Han, X. Liu, H. Xu, M. Zhang , Q. Shao and L. Qi (2014). "Chronic intake of high fish oil diet induces myeloid-derived suppressor cells to promote tumor growth." Cancer Immunol Immunother 63(7): 663-673.
12.Chen, Z., Y. Han, Y. Gu, Y. Liu, Z. Jiang, M. Zhang and X. Cao* (2013). "CD11c(high)CD8+ regulatory T cell feedback inhibits CD4 T cell immune response via Fas ligand-Fas pathway." J Immunol 190(12): 6145-6154.
13.Zhong, K., W. Song, Q. Wang, C. Wang, X. Liu, D. Chen, Z. Zhu, Y. Wu, W. Zhang* and M. Zhang *.(2012). "Murine myeloid dendritic cells that phagocytose apoptotic T cells inhibit the immune response via NO." PLoS One 7(11): e49378.
14.Jia, D., W. Rao, C. Wang, C. Jin, S. Wang, D. Chen, M. Zhang , J. Guo, Z. Chang and J. Liu* (2011). "Inhibition of B16 murine melanoma metastasis and enhancement of immunity by fever-range whole body hyperthermia." Int J Hyperthermia 27(3): 275-285.
15.Bai, B., Song, W., Ji, Y., Liu, X., Tian, L., Wang, C., Chen, D., Zhang, X and M. Zhang *.(2009). Microglia and microglia-like cell differentiated from DC inhibit CD4 T cell proliferation. PloS one, 4(11), e7869.
16.Tang, H., Z. Guo, M. Zhang, J. Wang, G. Chen and X. Cao *(2006). "Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10." Blood 108(4): 1189-1197.
17.An, H., H. Xu, M. Zhang, J. Zhou, T. Feng, C. Qian, R. Qi and X. Cao* (2005). "Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism." Blood 105(12): 4685-4692.
18.Guo, J., M. Zhang, B. Wang, Z. Yuan, Z. Guo, T. Chen, Y. Yu, Z. Qin and X. Cao* (2003). "Fractalkine transgene induces T-cell-dependent antitumor immunity through chemoattraction and activation of dendritic cells." Int J Cancer 103(2): 212-220.
19.Guo, Z., M. Zhang, H. An, W. Chen, S. Liu, J. Guo, Y. Yu and X. Cao *(2003). "Fas ligation induces IL-1beta-dependent maturation and IL-1beta-independent survival of dendritic cells: different roles of ERK and NF-kappaB signaling pathways." Blood 102(13): 4441-4447.
20.Guo, Z., M. Zhang , H. Tang and X. Cao* (2005). "Fas signal links innate and adaptive immunity by promoting dendritic-cell secretion of CC and CXC chemokines." Blood 106(6): 2033-2041.
21.Han, Y., M. Zhang, N. Li, T. Chen, Y. Zhang, T. Wan and X. Cao* (2004). "KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity." Blood 104(9): 2858-2866.
22.Pan, J., M. Zhang, J. Wang, Q. Wang, D. Xia, W. Sun, L. Zhang, H. Yu and X. Cao* (2005). "Intratumoral injection of interferon-gamma gene-modified dendritic cells elicits potent antitumor effects: effective induction of tumor-specific CD8+ CTL response." J Cancer Res Clin Oncol 131(7): 468-478.
23.M. Zhang,H. Tang, Z. Guo, H. An, X. Zhu, W. Song, J. Guo, X. Huang, T. Chen, J. Wang and X. Cao* (2004). "Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells." Nat Immunol 5(11): 1124-1133.
24.王 盈，陈栋炜，张明徽*.特异性 CD8+T 细胞活化对树突状细胞的负向调节作用研究.免疫学杂志.2013 年 7 月 第 29 卷 第 7 期 [文章编号]1000-8861（2013）07-0561-05 DOI:10.13431/j.cnki.immunol.j.20130121（Wang Ying, Chen Dongwei, Zhang Minghui*. Research on the Negative Regulatory Effect of Activated Specific CD8+ T Cells on Dendritic Cells. Chinese Journal of Immunology. July 2013, Vol. 29, No. 7. [Article Number] 1000-8861(2013)07-0561-05. DOI: 10.13431/j.cnki.immunol.j.20130121）
25.孙兆金 , 王 超 , 刘 玺 , 王 茜 , 张明徽*.CD 8+ NKT和 CTL细胞抗肿瘤活性的比较.免疫学杂志.第 25卷 第 6期 2009年11月 [ 文章编号] 1000-8861( 2009) 06-0617-04DOI : 10. 13431/ j . cnki . im munol . j . 20090164（Sun Zhaojin, Wang Chao, Liu Xi, Wang Qian, Zhang Minghui*. Comparison of Anti-tumor Activity between CD8+ NKT and CTL Cells. Chinese Journal of Immunology. Vol. 25, No. 6, November 2009. [Article Number] 1000-8861(2009)06-0617-04. DOI: 10.13431/j.cnki.immunol.j.20090164）
26.田垒, 陈栋炜, 季业伟, 刘玺, 张明徽*. 陈德坤. 抗原浓度和DC数量对OT-I小鼠CD8+T细胞分化与增殖的影响. 西北农林科技大学学报(自然科学版), 37(09), pp 7-12, 2009/9/10.（Tian Lei, Chen Dongwei, Ji Yewei, Liu Xi, Zhang Minghui*, Chen Dekun. The Influence of Antigen Concentration and DC Number on the Differentiation and Proliferation of CD8+ T Cells in OT-I Mice. Journal of Northwest University for Nationalities (Natural Science Edition), 37(09), pp. 7-12, 10/09/2009.）
27.Wang Chao，Liu Xi，Ji Yewei，Chen Dongwei，Song Wengang，Zhang Minghui*，CD8dim vNKT cells are bifunctional effectors in antitumor immunity，14th International Congress of Immunology，Kansai，2010.8.22-2010.8.27
28.Zhang Minghui*，et al. CD8dim vNKT cells down regulate immune response in antigen specific and MHC-I restricted manners，14th International Congress of Immunology，Kansai，2010.8.22-2010.8.27
29.Zhang Minghui*，et al. Hepatic stroma-differentiated regulatory dendritic cells inhibit the proliferation of CD8 T cells，14th International Congress of Immunology，Kansai，2010.8.22-2010.8.27
30.Zhang Minghui*，et al. Phagocytosis to apoptotic bodies induces transformation from DC to DCreg，14th International Congress of Immunology，Kansai，2010.8.22-2010.8.27
31.张明徽. 吞噬凋亡小体使树突状细胞诱导分化为调节性树突状细胞. 第七届全国免疫学学术大会, 2010/10/23-2010/10/26, 北京, 2010/10/23, 墙报展示.
32.张明徽. CD8dim vNKT细胞具有抗原特异性和非特异性双重抗肿瘤作用. 第七届全国免疫学学术大会, 2010/10/23-2010/10/26, 北京, 2010/10/23, 墙报展示.
33.张明徽.肝脏基质细胞诱导分化的调节性树突状细胞抑制CD8+T细胞增殖. 第七届全国免疫学学术大会, 2010/10/23-2010/10/26, 北京, 2010/10/23, 墙报展示.
34.张明徽.抗凝血因子VII多克隆抗体的杂交瘤细胞株:中国, 201510792378.4 发明专利，已授权
35.张明徽.抗α-抗胰蛋白酶多克隆抗体的杂交瘤细胞株:中国, 201510792392.4 发明专利，已授权
36.张明徽.抗巨球蛋白单克隆抗体的杂交瘤细胞株:中国, 201510792391.X 发明专利，已授权
37.张明徽.抗凝血因子IX单克隆抗体的杂交瘤细胞株:中国, 201510792380.1 发明专利，已授权（
38.张明徽.高红旗，宓林.免疫磁分离装置:中国，201520918181.6 实用新型，已授权
39.张明徽.抗凝血因子VIII单克隆抗体的杂交瘤细胞株:中国, 201510789803.4 发明专利，已授权
40.张明徽. 新型NKT样细胞亚群及其治疗肿瘤的用途：中国，201510494011.4 发明专利
41.Zhang Minghui. NKT-LIKE CELL SUBPOPULATION AND METHOD OF USING THE SAME IN THE TREATMENT OF TUMOR: 美国，US 10149863 美国发明专利，已授权。
42.张明徽. 一种抗肿瘤药物及其制备方法:中国, 201811331747.X 发明专利
