教育背景
2005-2010 北京大学医学部 学士
2010-2015 北京大学基础医学院免疫学系 博士
工作经历
2015-2021 清华大学医学院 博士后
2022-2024 清华大学医学院 助理研究员
2024-至今 清华大学基础医学院 助理研究员
研究领域
肠道黏膜免疫与菌群调控机制，尤其是天然淋巴样细胞在感染、代谢性疾病、肿瘤发生等过程中与肠道菌群协同调控的机制。肿瘤微环境调控和新型肿瘤免疫治疗药物开发，着重发现肿瘤抑制性免疫微环境的调控机制和干预手段，通过开发新型免疫治疗药物实现对肿瘤免疫微环境的重塑。
科学贡献
发现ILC3的组织异质性以及ILC3通过和T细胞相互作用调节肠道黏膜体液免疫新机制；发现ILC3通过影响黏液蛋白糖基化修饰调控肠道共生菌进而影响病原体感染的新机制，研究揭示了肠道黏膜免疫反应过程中天然免疫与获得性免疫系统之间复杂的相互作用，阐释了新的宿主-菌群-病原菌的相互作用机制。发现早产儿天然淋巴样细胞发育缺陷与新生儿疾病相关，发现天然淋巴样细胞在胃炎-癌前病变-胃癌进展过程中的动态变化，为癌前干预和胃癌早期诊断提供了新的靶点依据。以第一作者或通讯作者在Cell Stem Cell、Cell Reports、Science Bulletin、JACI等杂志发表论文20余篇，曾获得国际免疫联合会青年免疫学家奖，研究成果曾获得北京市科技进步二等奖。
荣誉奖励
2013. IUIS青年免疫学家奖
2013-2015. 国家奖学金，北京市优秀毕业生
代表性论文
1.Wenyan Wang; Yang-xin Fu ; Promises and Challenges of Organoids: From Humanized to Human Derived, Cell Stem Cell, 2024, 31(3) (co-corresponding author)
2.Wenyan Wang; Na Li; Xiaohuan Guo ; The crosstalk between ILC3s and adaptive immunity in diseases, The FEBS Journal, 2023, 2023(11): 1-13
3.Weiwei Fu*; Wenyan Wang*; Jing zhang; Yang Zhao; Keyan Chen; Ye Wang; Jing Zhang; Ying Xion g; Xiaohuan Guo; Shigang Ding ; Dynamic change of circulating innate and adaptive lymphocytes sub types during a cascade of gastric lesions, JOURNAL OF LEUKOCYTE BIOLOGY, 2022, 112(4): 931-938. (*co-first author)
4.Wenyan, Wang*; Yiping, Li*; Jiacheng, Hao; Yao, He; Xin, Dong; Yang-Xin, Fu; Xiaohuan, Guo ; The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the Mesenteric Lymph Node Restrains Intestinal Humoral Immunity, Cell Reports, 2020, 32(3): 0-107936. (*co-first author)
5.Wenyan, Wang*; Yan, Xing*; Yanmei, Chang; Ying, Wang; Yanxia, You; Zekun, Chen; Defu, Ma; X iaomei, Tong; Xiaohuan, Guo ; The impaired development of innate lymphoid cells by preterm birth is associated with the infant disease, Science Bulletin, 2020, 2021(5): 421-424. (*co-first author)
6.Wang W, Li Y, Guo X. (2020). A Mouse Model of Citrobacter rodentium Oral Infection and the Evaluation of Innate and Adaptive Immune Responses. STAR Protocols. 2020;1(3):100218.
7.Zou Z, Shen J, Xue D, Li H, Xu L, Cao W, Wang W, Fu YX, Peng H. Anti-PD-1 cis-delivery of low-affinity IL-12 activates intratumoral CD8+T cells for systemic antitumor responses. Nat Commun. 2024 Jun 3;15(1):4701.
8.Wang W, Li N, Xu H, Hao J, Huang J, Zhang J, Hu X, Guo X. (2024). Group 3 innate lymphoid cells regulates gut commensal microbiota by glycosylation for the pathogens defense. Nature Microbiology, Revised.
9.Shen J, Zou Z, Guo J, Cai Y, Xue D, Liang Y, Wang W, Peng H, Fu YX. An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery. J Exp Med. 2022 Dec 5;219(12):e20220745.
10.Fu L, Zhao J, Huang J, Li N, Dong X, He Y, Wang W, Wang Y, Qiu J, Guo X. A mitochondrial STAT3-methionine metabolism axis promotes ILC2-driven allergic lung inflammation. J Allergy Clin Immunol. 2022 Jun;149(6):2091-2104.
11.Huang J, Fu L, Huang J, Zhao J, Zhang X, Wang W, Liu Y, Sun B, Qiu J, Hu X, Liu Z, Guo X. Group 3 Innate Lymphoid Cells Protect the Host from the Uropathogenic Escherichia coli Infection in the Bladder. Adv Sci (Weinh). 2022 Feb;9(6):e2103303.
12.Yao He*; Liuhui Fu*; Yiping Li; Wenyan Wang; Mingli Gong; Jing Zhang; Xin Dong; Jiaoyan Hua ng; Quanbo Wang; Charles R Mackay; Yang-Xin Fu; Yun Chen; Xiaohuan Guo ; Gut microbial metabolite s facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity., Cell Metabolism, 2021, 2021(33): 988-1000. (*co-first author)
13.Li T*, Wang W*, Cheng Y, Han W. (2018). Method for quantitative detection of FAM19A4 by flow cytometry using latex beads as solid carrier. J Biosci Bioeng. 2018;125(3):359-364. (*co-first author)
14.Wang W, Li T, Wang X, Yuan W, et al. (2015). FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages. Cell Mol Immunol 2015;12(5):615-624.
15.Wang X*, Wang W*, Lin Z*, Wang X, et al. (2014). CARD9 mutations linked to subcutaneous phaeohyphomycosis and TH17 cell deficiencies. J Allergy Clin Immunol 2014;133(3):905-8.e3.(*co-first authors)
16.Wang X, Li T, Wang W, Yuan W, et al. (2016). Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2. J Immunol. 2016;196(10):4090-4099.
17.Yuan W, Li T, Mo X, Wang X, Liu B, Wang W, Su Y, Xu L, Han W. Knockdown of CMTM3 promotes metastasis of gastric cancer via the STAT3/Twist1/EMT signaling pathway. Oncotarget. 2016 May 17;7(20):29507-19.
18.Li T, Cheng Y, Wang P, Wang W, et al. (2015) CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma. J Exp Clin Cancer Res. 2015;34:122.
19.Li T, Guo X, Wang W, Mo X, et al. (2015). VSTM1 is silenced in human hematopoietic malignancy cell lines with promoter methylation and has inhibitory effects on cell growth. Mol Med Rep. 2015;11(2):1344-1351.
20.Li T, Wang W, Chen Y, Han W. Preparation and characterization of monoclonal antibodies against VSTM1. Monoclon Antib Immunodiagn Immunother. 2013 Aug;32(4):283-9.
