教育背景

1988-1992 山东师范大学生物系，学士

1992-1995 东北农业大学动物科学系，硕士

1997-2000 北京大学生命科学学院,博士

工作经历

2000-2008 荷兰癌症研究所,博士后

2008-2010 清华大学生物医学测试中心实验动物平台,主管

2011-今 清华大学基础医学院,医学实验教学中心,主任

研究领域

●家族性乳腺癌发生的分子机制

●雌性激素在乳腺肿瘤发生过程中的分子调控机理

●肿瘤浸润迁移的分子机制

●肿瘤基因组学及基因治疗

讲授课程

《医学生理学》

《社区医学实践》

代表性论文

1. Marieke van de Ven*, Xiaoling Liu *, Eline van der Burg, Sjoerd Klarenbeek, Xanthippi Alexi 3, Wilbert Zwart, Fred Dijcks, Peter Bouwman and Jos Jonkers. BRCA1 -associated mammary tumourigenesis is dependent on oestrogen rather than progesterone signaling. J Pathology. 2018 Sep;246(1):41-53. doi: 10.1002/path.5105.

*Equal contribution

2. Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P, Peterse JL, Cardiff RD, Berns A, Jonkers J. Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell. 2006 Nov;10(5):437-49.

3. Silver DP, Dimitrov SD, Feunteun J, Gelman R, Drapkin R, Lu SD, Shestakova E, Velmurugan S, Denunzio N, Dragomir S, Mar J, Liu X, Rottenberg S, Jonkers J, Ganesan S, Livingston DM. Further evidence for BRCA1 communication with the inactive X chromosome. Cell. 2007 Mar 9;128(5):991-1002.

4. Wijnhoven SW, Speksnijder EN, Liu X, Zwart E, vanOostrom CT, Beems RB, Hoogervorst EM, Schaap MM, Attardi LD, Jacks T, van Steeg H, Jonkers J, de Vries A. Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage. Cancer Res. 2007 May 15;67(10):4648-56.

5. *Liu X, Holstege H, van der Gulden H, Treur-Mulder M, Zevenhoven J, Velds A, Kerkhoven RM, van Vliet MH, Wessels LF, Peterse JL, Berns A, Jonkers J. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6.

*This article has been highlighted by Nature Reviews Cancer, 2007, Sept. Vol.7: nrc 2213