教育背景
1998-2002, 清华大学, 生物科学与技术, 学士
2003-2009, 美国德克萨斯大学西南医学中心, 遗传与发育, 博士
工作经历
2009-2011, 美国基因泰克公司 博士后
2011-2014, 美国洛克菲勒大学 博士后
2014-2020，清华大学免疫学研究所、医学院、生命科学联合中心 特别研究员
2020-2023，清华大学免疫学研究所、医学院 副教授（长聘）
2023-2024，清华大学免疫学研究所、医学院 教授
2024-至今，清华大学免疫学研究所、基础医学院 教授
2024-至今 Molecular Immunology副主编
2022-至今 AJP-Endo 副主编
2023-至今 编委, Protein & Cell
2023-至今 编委, Science Bulletin
2023-至今 编委, Journal of Genetics and Genomics
2022-至今 编委, Advanced Science
2020-至今 编委, Oxford Open Immunology
研究领域
致力于外周神经在脑与外周链接中的生理与病理研究，解析其在能量稳态中的功能，探索神经系统参与代谢和免疫应答的生理功能和相关疾病，发展基于神经免疫的干预策略。
4）科学贡献：
科研聚焦外周神经系统在大脑和器官之间的重要桥梁作用。研究阐明了神经系统与器官间的互作网络：描绘了脂肪、肠道中的自主神经支配图谱，揭示了脂肪内神经支配在病理生理条件下的可塑性变化、调控机制及对代谢活动的影响，鉴定了介导交感神经调控脂肪消耗的重要下游分子，发现了交感神经调控肠道神经内分泌细胞、控制血糖、影响认知行为的关键作用，发现了神经免疫经由外周-中枢传递的细胞通路及调控功能。
荣誉奖励
2023 中国细胞生物学学会青年女科学家职业发展基金奖
2022 基金委杰出青年基金
2018 基金委优秀青年基金
2018 生物物理学会脂质代谢与生物能学分会青年科学家奖
2016 求是基金会杰出青年科学家奖
2015 国家青年人才
代表性论文
1.Dai Y.*, Ni X.*, Zeng W.# (2024) Neuroimmune interaction of the lung. Biomedical Transformation.
2.Ding, X.*, Sun, M.*, Guo, F.*, Qian, X.*, Yuan, H., Lou, W., Wang, Q., Lei, X.#, Zeng, W.# (2024) Picrasidine S induces cGAS-mediated cellular immune response as a novel vaccine adjuvant. Advanced Science.
3.Qian, X.*, Tong, M.*, Zhang, T.*, Li, Q., Hua, M., Zhou, N., Zeng, W.# (2024) IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses. Protein & Cell.
4.Zhang, T.*, Qian, X.*, Li, Q., Du, X., Fu, X., Gu, H., Zeng, W.#, Wei, B.# (2024) Programmable in vitro and in vivo folding of single-stranded nucleic acid wireframe origami. Chem.
5.Ren, W., Chen, J., Wang, W., Li, Q., Yin, X., Zhuang, G., Zhou, H.#, Zeng, W.# (2024) Sympathetic nerve-enteroendocrine L cell communication modulates GLP-1 release, brain glucose utilization, and cognitive function. Neuron. 112(6): 972-990 e8.
6.Ren, W.*, Hua, M.*, Cao, F.#, Zeng, W.# (2024) The sympathetic-immune milieu in metabolic health and diseases: insights from pancreas, liver, intestine and adipose tissues. Adv Sci. 11(8): e2306128.
7.Ding, X., Chen J., and Zeng, W.# (2024) Neuroimmune regulation in the pancreas. Fundamental Research. 4(2):201-205
8.Wan, Y. and Zeng, W.# (2023) Neural innervation and regulation of adipose tissue. Progress in Physiological Sciences.
9.Sun, M.*, Wan, Y.*, Sun, M.*, Meng, Z.#, Zeng, W.# (2023) Neural innervation in adipose tissue, gut, pancreas, and liver. Life Metab. 2(4).
10.Zhang, S., Chen, J., Li, Q., and Zeng, W.# (2023) Opioid growth factor receptor promotes adipose tissue thermogenesis via enhancing lipid oxidation. Life Metab. 2(3).
11.Zhang, T.*#, Qian, X.*, Zeng, W.#, and Wei, B.# (2023) Custom folding of double-stranded DNA directed by triplex formation. Chem. 9(6): 1507-1517.
12.Li, Q., and Zeng, W.# (2023) Sensing and acting: Full circle in fat. Cell Metab. 35(1):9-11.
13.Jiang, M., and Zeng, W.# (2023) Antiviral immunity rewired for axon regeneration. Cell Rep Med. 4(1):100907.
14.Liu, Z., Xie, H., Li, L., Jiang, D., Qian, Y., Zhu, X., Dai, M., Li, Y., Wei, R., Luo, Z., Xu, W., Zheng, Q., Shen, J., Zhou, M., Zeng, W.# and Chen, W.# (2023). Single-cell landscape reveals the epithelial cell-centric pro-inflammatory immune microenvironment in dry eye development. Mucosal Immunol. 10.1016/j.mucimm.2023.11.008.
15.Meng, X., Chen J.#, and Zeng, W.# (2023) Stromal cell-derived NGF controls sympathetic innervation in subcutaneous fat. J Lipid Res. 64(2):100264.
16.Guo, Z., Yang, H., Zhang, J.R., Zeng, W.#, and Hu, X.# (2022) Leptin receptor signaling sustains metabolic fitness of alveolar macrophages to attenuate pulmonary inflammation. Sci Adv 8(28): eabo3064.
17.Zeng, W.#, Yang, F.#, Shen, W.#, Zhan, C.#, Zheng, P.#, and Hu, J. (2022) Interactions between central nervous system and peripheral metabolic organs, Science China Life Sciences. 65(10):1929-1958.
18.Xie, H., Heier, C., Meng, X., Bakiri, L., Pototschnig, I., Tang, Z., Schauer, S., Baumgartner, V.J., Grabner, G.F., Schabbauer, G., Wolinski, H., Robertsong, G.R., Hoefler, G., Zeng, W., Wagner, E.F., Schweiger, M.#, and Zechner, R.# (2022) An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia, Proc Natl Acad Sci U S A. 119(9).
19.Meng, X.*, Qian, X.*, Ding, X.*, Wang, W.*, Yin, X.#, Zhuang, G.#, and Zeng, W.# (2022) Eosinophils regulate intra-adipose axonal plasticity, Proc Natl Acad Sci U S A. 119(3).
20.Qian, X., Meng, X., Zhang, S., and Zeng, W.# (2022) Neuroimmune regulation of white adipose tissues. FEBS J. 289(24), 7830-7853.
21.Zeng, W.#, and Qian, X. (2021) Neuronal regulation of adipose tissue biology in neuron signaling in metabolic regulation (Tong, Q., ed), CRC Press.
22.Meng, X., and Zeng, W.# (2021) Fat mesenchyme closes the neural-ILC2 circuit, Immunity. 54(10), 2191-2193.
23.Zhuo, W.#, Zhou, H., Guo, R., Yi, J., Zhang, L., Yu, L., Sui, Y., Zeng, W., Wang, P.#, and Yang, M.# (2021) Structure of intact human MCU supercomplex with the auxiliary MICU subunits, Protein Cell. 12(3), 220-229.
24.Zhang, S., Zhou, J., Zhang, Y., Liu, T., Friedel, P., Zhuo, W., Somasekharan, S., Roy, K., Zhang, L., Liu, Y., Meng, X., Deng, H., Zeng, W., Li, G.#, Forbush, B.#, and Yang, M.# (2021) The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2, Commun Biol. 4(1), 226.
25.Sui, Y., and Zeng, W.# (2020) MS4A4A regulates Arginase 1 induction during macrophage polarization and lung inflammation in mice, Eur J Immunol. 50(10), 1602-1605.
26.Meng, X., Zeng, W., Young, S. G.#, and Fong, L. G. (2020) GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells, J Lipid Res. 61(5), 591.
27.Hu, Z.*, Deng, N.*, Liu, K., Zhou, N., Sun, Y., and Zeng, W.# (2020) CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across Schwann Cell-Neuron-Microglia, Cell Rep. 31(7), 107657.
28.Hu, Z., Deng, N., Liu, K., and Zeng, W.# (2019) DLK mediates the neuronal intrinsic immune response and regulates glial reaction and neuropathic pain, Exp Neurol. 322, 113056.
29.Wang, Q.*, Zhang, S.*, Liu, T.*, Wang, H., Liu, K., Wang, Q., and Zeng, W.# (2018) Sarm1/Myd88-5 Regulates Neuronal Intrinsic Immune Response to Traumatic Axonal Injuries, Cell Rep. 23(3), 716-724.
30.Hu, Z., and Zeng, W.# (2018). Splenic Leukocytes Get the Nerves up for Myelopoiesis. Immunity. 49(1), 1-3.
31.Zhang, S.*, Li, N.*, Zeng, W., Gao, N.#, and Yang, M.# (2017). Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism. Protein Cell. 8(11), 834-847.
32.Jiang, H.*, Ding, X.*, Cao, Y., Wang, H., and Zeng, W.# (2017). Dense Intra-adipose Sympathetic Arborizations Are Essential for Cold-Induced Beiging of Mouse White Adipose Tissue. Cell Metab. 26(4), 686-692 e683.
33.Zeng, W.*, Pirzgalska, R.M.*, Pereira, M.M., Kubasova, N., Barateiro, A., Seixas, E., Lu, Y.H., Kozlova, A., Voss, H., Martins, G.G., et al. (2015). Sympathetic neuro-adipose connections mediate leptin-driven lipolysis. Cell. 163(1), 84-94.
34.Zeng, W.*, Lu, Y.H.*, Lee, J., and Friedman, J.M. # (2015). Reanalysis of parabiosis of obesity mutants in the age of leptin. Proc Natl Acad Sci U S A. 112(29), E3874-3882.
35.Peng, Y.*, Zeng, W.*, Ye, H., Han, K.H., Dharmarajan, V., Novick, S., Wilson, I.A., Griffin, P.R., Friedman, J.M., and Lerner, R.A.# (2015). A General Method for Insertion of Functional Proteins within Proteins via Combinatorial Selection of Permissive Junctions. Chem Biol. 22(8), 1134-1143.
36.Glasmacher, E.*, Agrawal, S.*, Chang, A.B.*, Murphy, T.L.*, Zeng, W.*, Vander Lugt, B., Khan, A.A., Ciofani, M., Spooner, C.J., Rutz, S., et al. (2012). A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science. 338(6109), 975-980.
37.Rutz, S., Noubade, R., Eidenschenk, C., Ota, N., Zeng, W., Zheng, Y., Hackney, J., Ding, J., Singh, H., and Ouyang, W.# (2011). Transcription factor c-Maf mediates the TGF-beta-dependent suppression of IL-22 production in T(H)17 cells. Nat Immunol. 12(12), 1238-1245.
38.Zeng, W.*, Sun, L.*, Jiang, X., Chen, X., Hou, F., Adhikari, A., Xu, M., and Chen, Z.J.# (2010). Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell. 141(2), 315-330.
39.Zeng, W., Xu, M., Liu, S., Sun, L.#, and Chen, Z.J.# (2009). Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. Mol Cell. 36(2), 315-325.
40.Xu, M., Skaug, B., Zeng, W., and Chen, Z.J.# (2009). A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol Cell. 36(2), 302-314.
41.Xia, Z.P., Sun, L., Chen, X., Pineda, G., Jiang, X., Adhikari, A., Zeng, W., and Chen, Z.J.# (2009). Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 461(7260), 114-119.
42.Zeng, W., and Chen, Z.J.# (2008). MITAgating viral infection. Immunity. 29(4), 513-515.
43.Yang, M., Xu, G., Li, S., Sun, L., Shi, N., Zeng, W., Pang, H., Zhang, W., and Rao, Z.# (2003). Crystallization and preliminary crystallographic analysis of the extracellular fragment of FcalphaRI/CD89. Acta Crystallogr D Biol Crystallogr. 59, 2251-2253.
44.Sun, Z.H., Lai, Y.L., Zeng, W., Zhao, D., Zuo, H.C., and Xie, Z.P.# (2003). Neural stem/progenitor cells survive and differentiate better in PD rats than in normal rats. Acta Neurochir Suppl. 87, 169-174.
45.Sun, Z.H., Lai, Y.L., Zeng, W., Zhao, D., Ye, Z.W., Zuo, H.C., and Xie, Z.P.# (2003). Mesencephalic progenitors can improve rotational behavior and reconstruct nigrostriatal pathway in PD rats. Acta Neurochir Suppl. 87, 175-180.
Complete list of publications: ORCID: 0000-0001-8544-3318
