教育背景

1978-1982：北京医科大学基础医学系，医学学士

1983-1985：北京医科大学，免疫学硕士

1987-1991： 澳大利亚墨尔本大学 医学生物学系，博士

工作经历

1991-1995： 澳大利亚墨尔本 霍尔医学研究所(WEHI), 博士后

1996-2000： 澳大利亚墨尔本 霍尔医学研究所，研究员

2001-2005： 北京大学医学部，长江学者讲座教授

2001-2009: 澳大利亚墨尔本 霍尔医学研究所, 高级研究员，研究室主任

2010-2024： 清华大学医学院教授

2015-2021： 清华大学医学院副院长

2015-至今： 清华大学免疫学研究所 副所长

2024-至今： 清华大学基础医学院教授

主要研究领域

⟡免疫细胞发育分化的分子调控

⟡树突状细胞分化及功能在维持机体免疫稳态和相关疾病中的作用

⟡固有免疫细胞在肿瘤微环境及抗肿瘤免疫中的作用

学术贡献

从事细胞免疫学研究30 余年，在免疫细胞发育分化及分子调控的研究领域取得了多项原创性成果。研究成果发表在《自然》、《自然免疫》、《Immunity》等国际权威学术期刊160 余篇,论文被引用 23,000 余次(h-index=65)。主要研究成果包括：1）在国际上首次鉴定及分离出小鼠胸腺中最早期淋巴细胞系的前体细胞，并证实其分化成各种淋巴细胞的多能潜力，开拓了免疫细胞定向分化调节的新领域；2）首次证实具有高效抗原提呈能力的树突状细胞可由髓系和淋巴细胞的前体细胞分化而成，并鉴定了数个对树突状细胞亚群发育具有关键调控作用的转录因子；3）鉴定了胸腺树突状细胞的亚群，并阐明了这些亚群调节免疫应答及免疫耐受的作用机理；4）揭示了表观遗传对肠道树突状细胞及巨噬细胞维持肠道黏膜系统稳态的重要调控作用；5）开拓通过增强树突状细胞抗原提呈能力，提高抗肿瘤免疫应答及免疫疗法的新策略和新思路。

学术荣誉与奖励

2020 国家有突出贡献政府津贴获得者

2020 清华医学杰出贡献奖

2018 澳大利亚墨尔本大学 荣誉博士学位

2000 教育部 “长江学者” 讲座教授

2000 国家自然科学基金委 “海外杰出青年基金”

2009 国家高层次人才特聘专家

1996 澳大利亚霍尔医学研究所有突出贡献青年科学家“博奈特”奖

1996 美国纽约癌症研究所肿瘤免疫临床研究员奖

代表性论著

1.Wu L, Scollay R, Egerton M, Pearse M, Spangrude GJ, Shortman K. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 349: 71-74, 1991.

2.Wu L, Antica M, Johnson GR, Scollay R, Shortman K. Developmental potential of the earliest precursor cells from the adult mouse thymus. J Exp Med 174: 1617-1627, 1991.

3.Ardavin C, Wu L, Li C-L, Shortman K. Thymic dendritic cells and T cells develop simultaneously within the thymus from a common precursor population. Nature 362: 761-763, 1993.

4.Wu L, Nichogainnopoulou A, Shortman K, Georgopoulos K. Cell autonomous defects in udendritic cell populations of ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity, 7:483-492, 1997.

5.Wu L, D’Amico A, Winkel K.D, Suter M, Lo D, Shortman K. RelB is essential for the development of Myeloid-related CD8a- dendritic cells but not of lymphoid-related CD8a+ dendritic cells. Immunity, 9:839-847, 1998.

6.Wu L, D'Amico A, Hochrein H, O’Keeffe M, Shortman K and Lucas K. Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. Blood, u98:3376-3382, 2001.

7.D’Amico A and Wu L. The Early Progenitors of Mouse Dendritic Cells and Plasmacytoid pre-Dendritic Cells are within the Bone Marrow Hemopoietic Precursors Expressing Flt3. J. Exp. Med. 198:293-303, 2003.

8.Nutt S. L, Metcalf D., D’Amico A., Polli M. and Wu L. Dynamic Regulation of PU.1 Expression in Multipotent Hematopoietic Progenitors. J. Exp. Med. 201:221-231, 2005.

9.Naik SH, Proietto AI, Wilson NS, Dakic A, Schnorrer P, Fuchsberger M, Lahoud MH, O’Keeffe M, Shao QX, Chen WF, Villadangos JA, Shortman K, and Wu L. Cutting Edge: Generation of Splenic CD8+ and CD8- Dendritic Cell Equivalents in Fms-Like Tyrosine Kinase Ligand Bone Marrow Cultures. J. Immunol. 174:6592-6597, 2005.

10.Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, & Visvader JE. Generation of a functional mammary gland from a single stem cell. Nature. 439:84-88. 2006.

11.Naik SH, Sathe P, Park H-Y, Metcalf D, Anna I. Proietto AI, Dakic A, Carotta S, O’Keeffe M, Bahlo M, Papenfuss A, Kwak J-Y, Wu L and Shortman K. Development of plasmacytoid and conventional dendritic cell subtypes from single in vitro and in vivo- derived precursors. Nat. Immunol. 8:1217, 2007.

12.Wu L and Liu YJ. The Development of Dendritic Cell Lineages. Immunity. 26:741-750. 2007.

13.Proietto AI, van Dommelen S, Zhou P, Rizzitelli A, D'Amico A, Steptoe RJ, Naik SH, Lahoud MH, Liu Y, Zheng P, Shortman K and Wu L. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc Natl Acad Sci. USA. 105:19869-19874, 2008.

14.Carotta S., Dakic A., D’Amico A., Pang SHM., Greig KT, Nutt SL and Wu L. The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose Dependent Manner. Immunity. 28:628-41, 2010.

15.Wu L. A Flt3L Encounter: mTOR Signaling in Dendritic Cells. Immunity. 33:580-582, 2010.

16.Zhou HB, Xiao J, Wu N, Liu CX, Xu J, Liu F and Wu L. MicroRNA-223 Regulates the Differentiation and Function of Intestinal Dendritic cells and Macrophages by targeting C/EBPβ. Cell Reports 2015 Nov 10;13(6):1149-60. doi: 10.1016/j.celrep.2015.09.073.

17.Guo XH, Wu N, Shang YL，Liu X, Wu T, Zhou YF, Liu X, Huang JY, Liao XB and Wu L. The novel Toll-like receptor 2 agonist SUP3 enhances antigen Presentation and T cell activation by Dendritic cells. Front. Immunol. 8:158. doi: 10.3389/fimmu. 2017.00158.

18.Wu T and Wu L. Dendritic Cell Fate Determination Revealed by “SISter” Assays. Immunity. doi.org/10.1016/j.immuni.2021.05.012.

19.Tian YJ^#, Lv JY^#, Su ZY, Wu T, Li XG, Hu XY, Zhang JH, Wu L. LRRK2 plays essential roles in maintaining lung homeostasis and preventing the development of pulmonary fibrosis. PNAS 2021, Vol. 118 No. 35 e2106685118, https://doi.org/10.1073/pnas.2106685118.

20.Zhang Y, Wu T, He Z, Lai W, Shen X, Lv J, Wang Y and Wu L. Regulation of pDC fate determination by histone deacetylase. eLife, 2023, DOI: https://doi.org/10.7554/eLife.80477