教育背景

2003-2006年 中国科学技术大学学习，获得细胞生物学博士学位。

2000-2003年 山东省医学科学院学习，获得免疫学硕士学位。

工作经历

2024年-至今 清华大学基础医学院/免疫学研究所，研究员。

2011年-2024年 清华大学医学院

2006年-2011年 加拿大蒙特利尔临床研究所（IRCM），肿瘤免疫学博士后。

研究领域

自然杀伤细胞发育、分化和活化调控机制；肿瘤免疫学

科学贡献

系统解析SLAM家族受体的免疫调节作用；

发现NK细胞活化和耐受的新机制；

首次揭示SLAM家族受体为新型免疫检查点分子。

荣誉奖励

国家基金委杰出青年基金获得者（2017）

国家基金委优秀青年基金获得者（2013）

拜耳研究员（2020）

清华-杨森研究员（2012-2016）

加拿大CIHR Fellowship（2005-2008）

中华医学会科技一等奖1项（2007）

中科院院长奖 （2005）

代表性论文

1.Zhao R, Zhang J , Ma J, Qu Y, Yang Z, Yin Z , Li F, Dong Z , Sun Q, Shu Zhu W , Chen Z, and Gao D*, cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation. Sci. Immunol.9, eadk2612(2024). DOI:10.1126/sciimmunol.adk2612

2.Feng P, Yang Q, Luo L, Guan Z, Fu J, Zhao M, Men Wg, Wan S, He J, Zhizhong Li Z, Wang G, Sun G, Dong Z*, Yang M*. Vps34 sustains Treg cell survival and function via regulating intracellular redox homeostasis. Cell Death Differ (2024). https://doi.org/10.1038/s41418-024-01353-y.

3.Feng P, Luo L, Yang Q, Meng W, Guan Z, Li Z, Sun G, Dong Z*, Yang M*. Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity. Cell Death Dis 15, 430 (2024). https://doi.org/10.1038/s41419-024-06828-x

4.Chen S, Sun B, Dong Z*. Unleashing a safe and potent pro-senescence anti-tumor strategy. Cancer Cell. 2024 Feb 16:S1535-6108(24)00047-3.

5.He J, Chen D, Xiong W, Hou X, Quan Y, Yang M, Dong Z*. Eomesodermin spatiotemporally orchestrates the early and late stages of NK cell development by targeting KLF2 and T-bet, respectively. Cell Mol Immunol. 2024 Jul;21(7):662-673.

6.Wang Y, Quan Y, He J, Chen S, Dong Z*. SLAM-family receptors promote resolution of ILC2-mediated inflammation. Nat Commun. 2024 Jun 13;15(1):5056.

7.Chen S, Li Z, Feng J, Quan Y, He J, Hao J, Dong Z*. Dual Activity of Type III PI3K Kinase Vps34 is Critical for NK Cell Development and Senescence. Adv Sci. 2024 Jun;11(21):e2309315.

8.Niu S, Xia C, Huang D, Wang L, Hu H, Yu S, Wu N, Dong Z, Zhou J, Wu J, Yu J, Zhang Y, Wang C, Fu B, Cao J, Liang L, Xu L, Chen L, Zhou Q, Ma A, Zhao T, Hao J, Wang J*. Requirements for human natural killer cells. Cell Prolif. 2024 May;57(5):e13588. doi: 10.1111/cpr.13588. Epub 2023 Dec 20.

9.Luo L, Feng P, Yang Q, Lv W, Meng W, Yin Z, Li Z, Sun G, Dong Z*, Yang M. Transcription factor TOX maintains the expression of Mst1 in controlling the early mouse NK cell development. Theranostics 2023; 13(7):2072-2087.

10.Wu P, Zhang H, Sun M, Mao S, He Q, Shi Y, Deng Y, Dong Z, Xu Q, Zhao C, Zhang W, Sun B. Manipulating Offense and Defense Signaling to Fight Cold Tumors with Carrier-Free Nanoassembly of Fluorinated Prodrug and siRNA. Adv Mater. 2022 Sep;34(38):e2203019.

11. He Q, Lu Y, Tian W, Jiang R, Yu W, Liu Y, Sun M, Wang F, Zhang H, Wu N, Dong Z, Sun B. TOX deficiency facilitates the differentiation of IL-17A-producing γδT cells to drive autoimmune hepatitis. Cell Mol Immunol. 2022 Oct;19(10):1102-1116.

12.Li D, Xiong W, Wang Y, Feng J, He Y, Du J, Wang J, Yang M, Zeng H, Yang YG, Wu N, Chen S, Dong Z*. SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors. Sci Immunol. 2022 Jan 21;7(67):eabj5501.

13.Feng P, Yang Q, Luo L, Sun Y, Lv W, Wan S, Guan Z, Xiao Z, Liu F, Li Z, Dong Z*,Yang M*. The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis. Theranostics 2021; 11(19).

14.He J, Zhao J, Quan Y, Hou X, Yang M, Dong Z*. Full Activation of Kinase Protein Kinase B by Phosphoinositide-Dependent Protein Kinase-1 and Mammalian Target of Rapamycin Complex 2 Is Required for Early Natural Killer Cell Development and Survival. Front Immunol. 2021 Feb 9;11:617404.

15.Wu J, Li G, Li L, Li D, Dong Z, Jiang P*. Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses., Nat Cell Biol. 2021;23(1):75-86.

16.Li D, Wang Y, Yang M, Dong Z*. mTORC1 and mTORC2 coordinate early NK cell development by differentially inducing E4BP4 and T-bet. Cell Death Differ. 2021 Jan 18.

17.He YX, Du, J, Dong Z*. Myeloid deletion of phosphoinositide-dependent kinase-1 enhances NK cell-mediated antitumor immunity by mediating macrophage polarization. OncoImmunology, 2020 Jun 3;9(1):1774281

18.Zhou Y, Fu B, Xu X, Zhang J, Tong X, Wang Y, Dong Z, Zhang X, Shen N, Zhai Y, Kong X, Sun R, Tian Z, Wei H. PBX1 expression in uterine natural killer cells drives fetal growth. Sci Transl Med. 2020 Apr 1;12(537).

19.Xu X, Zhou Y, Fu B, Zhang J, Dong Z, Zhang X, Shen N, Sun R, Tian Z, Wei H. PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter. FASEB J. 2020 Mar 19.

20.Chen S, Li D, Wang Y, Li Q, Dong Z*. Regulation of MHC class I-independent NK cell education by SLAM family receptors. Adv Immunol. 2020;145:159-185.

21.Chen S, Dong Z*. Concomitant deletion of SLAM-family receptors, NKG2D and DNAM-1 reveals gene redundancy of NK cell activating receptors in NK cell development and education. J Leukoc Biol. 2020 Apr;107(4):561-572.

22.Zhang X, Feng J, Chen S, Yang H, Dong Z. Synergized regulation of NK cell education by NKG2A and specific Ly49 family members. Nat Commun. 2019 Nov 1;10(1):5010.

23.Chen S, Dong Z*. NK cell recognition of hematopoietic cells by SLAM-SAP families. Cell Mol Immunol. 2019 May;16(5):452-459.

24.Liu C, Zhou Y, Li M, Wang Y, Yang L, Yang S, Feng Y, Wang Y, Wang Y, Ren F, Li J, Dong Z, Chin YE, Fu X, Wu L, Chang Z. Absence of GdX/UBL4A Protects against Inflammatory Diseases by Regulating NF-кB Signaling in Macrophages and Dendritic Cells. Theranostics. 2019 Feb 14;9(5):1369-1384.

25.Zhou J, Peng H, Li K, Qu K, Wang B, Wu Y, Ye L, Dong Z, Wei H, Sun R, Tian Z. Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis. Immunity. 2019 Jan 24. (18)30572-7.

26.He J, Wang Y, Liu T, Liu G, Chen S, Li Q, Quan Y, Yang H, Feng J, Wang S, Yang M, Dong Z*. Stage-specific requirement of kinase PDK1 for NK cells development and activation. Cell Death Differ. 2019 Oct;26(10):1918-1928.

27.Zhou J, Lai W, Yang W, Pan J, Shen H, Cai Y, Yang C, Ma N, Zhang Y, Zhang R, Xie X, Dong Z, Gao Y, Du C. BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis. Cell Mol Immunol. 2018 Dec;15(12):1047-1056.

28.Zeng X, Liu G, Peng W, He J, Cai C, Xiong W, Chen S, Yang M, Dong Z*. Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages. Cell Mol Immunol. 2018 Dec 14.

29.Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z, Wei H. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors. Immunity. 2017 Dec 19;47(6):1100-1113.

30.Lee YH, Martin-Orozco N, Zheng P, Li J, Zhang P, Tan H, Park HJ, Jeong M,Chang SH, Kim BS, Xiong W, Zang W, Guo L, Liu Y, Dong Z, Overwijk WW, Hwu P, Yi Q, Kwak L, Yang Z, Mak TW, Li W, Radvanyi LG, Ni L, Liu D, Dong C. Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function. Cell Res. 2017 Aug;27(8):1034-1045.

31.Chen S, Li Z, Cai C, Liu GW, Wang Y, Blonska M, Dan Li D, Du J, Lin X, Yang M, and Dong Z*. Dissection of SAP-dependent and SAP-independent SLAM Family Signaling in NKT Cell Development and Humoral Immunity, Journal Experimental Medicine. 2017 Feb;214(2):475-489.

32.Chen S, Yang M, Du J, Li D, Li ZH, Cai C, Ma Y, Zhang Y, Tian Z^*, and Dong Z^*. The self-specific activation receptor SLAM family is critical to NK cell education. Immunity. 2016, 45(2): 292-304.

33.Yang M, Chen S, Du J, He J, Wang Y, Zehua, Li Z, Liu G, Peng W, Zeng X, Li D, Xu P, Guo W, Chang Z, Wang S, Tian Z and Dong Z*. NK cell development requires Tsc1-dependent negative regulation of IL-15-trgiggered mTORC1 activation. Nature Communications. 2016 Sep 7;7:12730

34.Wu N, Zhong MC, Roncagalli R, Pérez-Quintero LA, Guo H, Zhang Z, Lenoir C, Dong Z, Latour S, Veillette A. A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education. Nature Immunology. 2016 Apr;17(4):387-96.

35.Du J, Yang MX, Chen SS, Li D, Chang Z, and Dong Z* PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model. Oncogene, 2016;35(25):3314-23.

36.Yang M, Li D, Chang Z, Yang Z, Tian Z, Dong Z*. PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness. Journal Experimental Medicine. 2015 212(2):253-65.

37.Chu C, Wang Y, Zhang X, Ni X, Cao J, Xu W, Dong Z, Yuan P, Wei W, Ma Y, Zhang L, Wu L, Qi H. SAP-regulated T Cell-APC adhesion and ligation-dependent and-independent Ly108-CD3ζ interactions. J Immunol. 2014 Oct 15;193(8):3860-71.

38.Dong Z*, Davidson D, Pérez-Quintero L.A, Kurosaki T, Swat W, and Veillette A. The Adaptor SAP Controls NK Cell Activation by Regulating the Enzymes Vav-1 and SHIP-1 and by Enhancing Conjugates with Target Cells. Immunity, 2012; 36(6):974-85.

39.Guimont-Desrochers F, Boucher G, Dong Z, Dupuis M, Veillette A, Lesage. Redefining interferon-producing killer dendritic cells as a novel intermediate in NK cell differentiation. Blood;119(19):4349-57.

40.Dong Z, Veillette A. How do SAP family deficiencies compromise immunity? Trends in Immunology; 2010 Aug;31(8):295-302

41.Veillette A, Dong Z, Zhong M, Cruz-Munoz ME. Importance and mechanism of “switch” function of SAP family adaptors. Immunological Reviews. 2009,232(1); 2009:229-39.

42.Dong Z, Cruz-Munoz ME, Zhong M, Chen R, Latour S and Veillette A. Essential role of SAP family adaptors in natural killer cell surveillance of hematopoietic cells. Nature Immunology; 10(9); (2009):973-80.

43.Cruz-Munoz ME, Dong Z, Shi X, Zhang S, Veillette A. Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nature Immunology; 10(3); (2009):297-305.

44.Veillette A, Zhang S, Shi X, Dong Z, Davidson D and Zhong M. SAP expression in T cells, not in B cells, is required for humoral immunity. PNAS; 105(4); (2008):1273-8

45.Dong Z, Zhang J, Sun R, Wei H, Tian Z. Impairment of liver regeneration correlates with activated hepatic NKT cells in HBV transgenic mice. Hepatology;45(6); (2007):1400-12.

46.Veillette A, Dong Z, Latour S. Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes. Immunity; 27(5); (2007):698-710.

47.Chen Y, Wei H, Sun R, Dong Z, Zhang J, Tian Z. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. Hepatology; 46(3); (2007):706-15.

48.Dong Z, Wei H, Sun R, Tian Z. The roles of innate immune cells in liver injury and regeneration. Cellular and Molecular Immunology; 4(4); (2007):241-52.

49.Shi Q, Dong Z, Wei H. The involvement of heat shock proteins in murine liver regeneration. Cellular and Molecular Immunology.4(1) ;(2007):53-7.

50.Wang J, Sun R, Wei H, Dong Z, Gao B, Tian Z. Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism. Journal of Hepatology; 44(3) ;(2006):446-54.

51.Zhang J, Dong Z, Zhou R, Luo D, Wei H, Tian Z. Isolation of lymphocytes and their innate immune characterizations from liver, intestine, lung and uterus. Cellular and Molecular Immunology;2(4) ;(2005):271-80.

52.Dong Z, Tian Z. APC-independent NK cell activation. Journal of Immunology. 2005 15;175(4):2041

53.Dong Z, Wei H, Sun R, Hu Z, Gao B, Tian Z. Involvement of natural killer cells in Poly I:C- induced liver injury. Journal of Hepatology; 41(6) ;(2004):966-73.

1、Education；

2000-2003 Shandong Academy of Medical Sciences, Jinan, China, Major: Medical Immunology，Master awarded

2003-2006 University of Science and Technology of China. Hefei, China, Major in Cell biology, Ph.D awarded

2、Professional Positions；

Aug, 2017- Current Associate Professor (Tenured), School of Medicine, Institute for Immunology, Tsinghua University

Aug, 2011-June, 2017 Assistant Professor, School of Medicine, Institute for Immunology, Tsinghua University

2006-2011 Clinical Research Institute of Montreal, Canada, Postdoctoral Fellow, Advisor: Andre Veillette, M.D

3、Research Areas；

NK cell biology；tumor immunology

4、Honors and Awards；

The National Science Fund for Distinguished Young Scholars (2017)

The National Science Fund for Excllent Young Scholars (2013)

Bayer investigator (2020)

Jansen-Tsinghua Fellowship(2012-2016:);

Canadian Institutes of Health Research (CIHR) Fellowship, CIHR,

Canada (2008-2011:);

Angelo Pizzagalli Postdoctoral Fellowship, Institut de Recherches cliniques (2007)

de Montreal;

Presidential Scholarship of Chinese Academy of Sciences (CAS) (2005);

5、Selected Publications。

1、Zhao R, Zhang J , Ma J, Qu Y, Yang Z, Yin Z , Li F, Dong Z , Sun Q, Shu Zhu W , Chen Z, and Gao D*, cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation. Sci. Immunol.9, eadk2612(2024). DOI:10.1126/sciimmunol.adk2612

2、Feng P, Yang Q, Luo L, Guan Z, Fu J, Zhao M, Men Wg, Wan S, He J, Zhizhong Li Z, Wang G, Sun G, Dong Z*, Yang M*. Vps34 sustains Treg cell survival and function via regulating intracellular redox homeostasis. Cell Death Differ (2024). https://doi.org/10.1038/s41418-024-01353-y.

3、Feng P, Luo L, Yang Q, Meng W, Guan Z, Li Z, Sun G, Dong Z*, Yang M*. Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity. Cell Death Dis 15, 430 (2024). https://doi.org/10.1038/s41419-024-06828-x

4、Chen S, Sun B, Dong Z*. Unleashing a safe and potent pro-senescence anti-tumor strategy. Cancer Cell. 2024 Feb 16:S1535-6108(24)00047-3.

5、He J, Chen D, Xiong W, Hou X, Quan Y, Yang M, Dong Z*. Eomesodermin spatiotemporally orchestrates the early and late stages of NK cell development by targeting KLF2 and T-bet, respectively. Cell Mol Immunol. 2024 Jul;21(7):662-673.

6、Wang Y, Quan Y, He J, Chen S, Dong Z*. SLAM-family receptors promote resolution of ILC2-mediated inflammation. Nat Commun. 2024 Jun 13;15(1):5056.

7、Chen S, Li Z, Feng J, Quan Y, He J, Hao J, Dong Z*. Dual Activity of Type III PI3K Kinase Vps34 is Critical for NK Cell Development and Senescence. Adv Sci. 2024 Jun;11(21):e2309315.

8、Niu S, Xia C, Huang D, Wang L, Hu H, Yu S, Wu N, Dong Z, Zhou J, Wu J, Yu J, Zhang Y, Wang C, Fu B, Cao J, Liang L, Xu L, Chen L, Zhou Q, Ma A, Zhao T, Hao J, Wang J*. Requirements for human natural killer cells. Cell Prolif. 2024 May;57(5):e13588. doi: 10.1111/cpr.13588. Epub 2023 Dec 20.

9、Luo L, Feng P, Yang Q, Lv W, Meng W, Yin Z, Li Z, Sun G, Dong Z*, Yang M. Transcription factor TOX maintains the expression of Mst1 in controlling the early mouse NK cell development. Theranostics 2023; 13(7):2072-2087.

10、Wu P, Zhang H, Sun M, Mao S, He Q, Shi Y, Deng Y, Dong Z, Xu Q, Zhao C, Zhang W, Sun B. Manipulating Offense and Defense Signaling to Fight Cold Tumors with Carrier-Free Nanoassembly of Fluorinated Prodrug and siRNA. Adv Mater. 2022 Sep;34(38):e2203019.

11、 He Q, Lu Y, Tian W, Jiang R, Yu W, Liu Y, Sun M, Wang F, Zhang H, Wu N, Dong Z, Sun B. TOX deficiency facilitates the differentiation of IL-17A-producing γδT cells to drive autoimmune hepatitis. Cell Mol Immunol. 2022 Oct;19(10):1102-1116.

12、Li D, Xiong W, Wang Y, Feng J, He Y, Du J, Wang J, Yang M, Zeng H, Yang YG, Wu N, Chen S, Dong Z*. SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors. Sci Immunol. 2022 Jan 21;7(67):eabj5501.

13、Feng P, Yang Q, Luo L, Sun Y, Lv W, Wan S, Guan Z, Xiao Z, Liu F, Li Z, Dong Z*,Yang M*. The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis. Theranostics 2021; 11(19).

14、He J, Zhao J, Quan Y, Hou X, Yang M, Dong Z*. Full Activation of Kinase Protein Kinase B by Phosphoinositide-Dependent Protein Kinase-1 and Mammalian Target of Rapamycin Complex 2 Is Required for Early Natural Killer Cell Development and Survival. Front Immunol. 2021 Feb 9;11:617404.

15、Wu J, Li G, Li L, Li D, Dong Z, Jiang P*. Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses., Nat Cell Biol. 2021;23(1):75-86.

16、Li D, Wang Y, Yang M, Dong Z*. mTORC1 and mTORC2 coordinate early NK cell development by differentially inducing E4BP4 and T-bet. Cell Death Differ. 2021 Jan 18.

17、He YX, Du, J, Dong Z*. Myeloid deletion of phosphoinositide-dependent kinase-1 enhances NK cell-mediated antitumor immunity by mediating macrophage polarization. OncoImmunology, 2020 Jun 3;9(1):1774281

18、Zhou Y, Fu B, Xu X, Zhang J, Tong X, Wang Y, Dong Z, Zhang X, Shen N, Zhai Y, Kong X, Sun R, Tian Z, Wei H. PBX1 expression in uterine natural killer cells drives fetal growth. Sci Transl Med. 2020 Apr 1;12(537).

19、Xu X, Zhou Y, Fu B, Zhang J, Dong Z, Zhang X, Shen N, Sun R, Tian Z, Wei H. PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter. FASEB J. 2020 Mar 19.

20、Chen S, Li D, Wang Y, Li Q, Dong Z*. Regulation of MHC class I-independent NK cell education by SLAM family receptors. Adv Immunol. 2020;145:159-185.

21、Chen S, Dong Z*. Concomitant deletion of SLAM-family receptors, NKG2D and DNAM-1 reveals gene redundancy of NK cell activating receptors in NK cell development and education. J Leukoc Biol. 2020 Apr;107(4):561-572.

22、Zhang X, Feng J, Chen S, Yang H, Dong Z. Synergized regulation of NK cell education by NKG2A and specific Ly49 family members. Nat Commun. 2019 Nov 1;10(1):5010.

23、Chen S, Dong Z*. NK cell recognition of hematopoietic cells by SLAM-SAP families. Cell Mol Immunol. 2019 May;16(5):452-459.

24、Liu C, Zhou Y, Li M, Wang Y, Yang L, Yang S, Feng Y, Wang Y, Wang Y, Ren F, Li J, Dong Z, Chin YE, Fu X, Wu L, Chang Z. Absence of GdX/UBL4A Protects against Inflammatory Diseases by Regulating NF-кB Signaling in Macrophages and Dendritic Cells. Theranostics. 2019 Feb 14;9(5):1369-1384.

25、Zhou J, Peng H, Li K, Qu K, Wang B, Wu Y, Ye L, Dong Z, Wei H, Sun R, Tian Z. Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis. Immunity. 2019 Jan 24. (18)30572-7.

26、He J, Wang Y, Liu T, Liu G, Chen S, Li Q, Quan Y, Yang H, Feng J, Wang S, Yang M, Dong Z*. Stage-specific requirement of kinase PDK1 for NK cells development and activation. Cell Death Differ. 2019 Oct;26(10):1918-1928.

27、Zhou J, Lai W, Yang W, Pan J, Shen H, Cai Y, Yang C, Ma N, Zhang Y, Zhang R, Xie X, Dong Z, Gao Y, Du C. BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis. Cell Mol Immunol. 2018 Dec;15(12):1047-1056.

28、Zeng X, Liu G, Peng W, He J, Cai C, Xiong W, Chen S, Yang M, Dong Z*. Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages. Cell Mol Immunol. 2018 Dec 14.

29、Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z, Wei H. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors. Immunity. 2017 Dec 19;47(6):1100-1113.

30、Lee YH, Martin-Orozco N, Zheng P, Li J, Zhang P, Tan H, Park HJ, Jeong M,Chang SH, Kim BS, Xiong W, Zang W, Guo L, Liu Y, Dong Z, Overwijk WW, Hwu P, Yi Q, Kwak L, Yang Z, Mak TW, Li W, Radvanyi LG, Ni L, Liu D, Dong C. Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function. Cell Res. 2017 Aug;27(8):1034-1045.

31、Chen S, Li Z, Cai C, Liu GW, Wang Y, Blonska M, Dan Li D, Du J, Lin X, Yang M, and Dong Z*. Dissection of SAP-dependent and SAP-independent SLAM Family Signaling in NKT Cell Development and Humoral Immunity, Journal Experimental Medicine. 2017 Feb;214(2):475-489.

32、Chen S, Yang M, Du J, Li D, Li ZH, Cai C, Ma Y, Zhang Y, Tian Z^*, and Dong Z^*. The self-specific activation receptor SLAM family is critical to NK cell education. Immunity. 2016, 45(2): 292-304.

33、Yang M, Chen S, Du J, He J, Wang Y, Zehua, Li Z, Liu G, Peng W, Zeng X, Li D, Xu P, Guo W, Chang Z, Wang S, Tian Z and Dong Z*. NK cell development requires Tsc1-dependent negative regulation of IL-15-trgiggered mTORC1 activation. Nature Communications. 2016 Sep 7;7:12730

34、Wu N, Zhong MC, Roncagalli R, Pérez-Quintero LA, Guo H, Zhang Z, Lenoir C, Dong Z, Latour S, Veillette A. A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education. Nature Immunology. 2016 Apr;17(4):387-96.

35、Du J, Yang MX, Chen SS, Li D, Chang Z, and Dong Z* PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model. Oncogene, 2016;35(25):3314-23.

36、Yang M, Li D, Chang Z, Yang Z, Tian Z, Dong Z*. PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness. Journal Experimental Medicine. 2015 212(2):253-65.

37、Chu C, Wang Y, Zhang X, Ni X, Cao J, Xu W, Dong Z, Yuan P, Wei W, Ma Y, Zhang L, Wu L, Qi H. SAP-regulated T Cell-APC adhesion and ligation-dependent and-independent Ly108-CD3ζ interactions. J Immunol. 2014 Oct 15;193(8):3860-71.

38、Dong Z*, Davidson D, Pérez-Quintero L.A, Kurosaki T, Swat W, and Veillette A. The Adaptor SAP Controls NK Cell Activation by Regulating the Enzymes Vav-1 and SHIP-1 and by Enhancing Conjugates with Target Cells. Immunity, 2012; 36(6):974-85.

39、Guimont-Desrochers F, Boucher G, Dong Z, Dupuis M, Veillette A, Lesage. Redefining interferon-producing killer dendritic cells as a novel intermediate in NK cell differentiation. Blood;119(19):4349-57.

40、Dong Z, Veillette A. How do SAP family deficiencies compromise immunity? Trends in Immunology; 2010 Aug;31(8):295-302

41、Veillette A, Dong Z, Zhong M, Cruz-Munoz ME. Importance and mechanism of “switch” function of SAP family adaptors. Immunological Reviews. 2009,232(1); 2009:229-39.

42、Dong Z, Cruz-Munoz ME, Zhong M, Chen R, Latour S and Veillette A. Essential role of SAP family adaptors in natural killer cell surveillance of hematopoietic cells. Nature Immunology; 10(9); (2009):973-80.

43、Cruz-Munoz ME, Dong Z, Shi X, Zhang S, Veillette A. Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nature Immunology; 10(3); (2009):297-305.

44、Veillette A, Zhang S, Shi X, Dong Z, Davidson D and Zhong M. SAP expression in T cells, not in B cells, is required for humoral immunity. PNAS; 105(4); (2008):1273-8

45、Dong Z, Zhang J, Sun R, Wei H, Tian Z. Impairment of liver regeneration correlates with activated hepatic NKT cells in HBV transgenic mice. Hepatology;45(6); (2007):1400-12.

46、Veillette A, Dong Z, Latour S. Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes. Immunity; 27(5); (2007):698-710.

47、Chen Y, Wei H, Sun R, Dong Z, Zhang J, Tian Z. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. Hepatology; 46(3); (2007):706-15.

48、Dong Z, Wei H, Sun R, Tian Z. The roles of innate immune cells in liver injury and regeneration. Cellular and Molecular Immunology; 4(4); (2007):241-52.

49、Shi Q, Dong Z, Wei H. The involvement of heat shock proteins in murine liver regeneration. Cellular and Molecular Immunology.4(1) ;(2007):53-7.

50、Wang J, Sun R, Wei H, Dong Z, Gao B, Tian Z. Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism. Journal of Hepatology; 44(3) ;(2006):446-54.

51、Zhang J, Dong Z, Zhou R, Luo D, Wei H, Tian Z. Isolation of lymphocytes and their innate immune characterizations from liver, intestine, lung and uterus. Cellular and Molecular Immunology;2(4) ;(2005):271-80.

52、Dong Z, Tian Z. APC-independent NK cell activation. Journal of Immunology. 2005 15;175(4):2041

53、Dong Z, Wei H, Sun R, Hu Z, Gao B, Tian Z. Involvement of natural killer cells in Poly I:C- induced liver injury. Journal of Hepatology; 41(6) ;(2004):966-73.