教育经历：

中国科学院，生物物理研究所, 感染与免疫科学中心

博士，细胞生物学 2007- 2012

首都医科大学,

学士，药学 2003-2007

工作经历:

基础医学院（原医学院基础医学系） 研究员 2017至今

芝加哥大学(The University of Chicago)

助理研究员 2016-2017

博士后学者 2013-2016

代表性论文：

1) Yu Wang#; Shaocun Zhang#*; Na Kang; Lihui Dong; Haochen Ni; Sichen Liu; Siankang Chong; Zhenglin Ji; Zhengpeng Wan; Xiangjun Chen; Fei Wang; Yun Lu; Baidong Hou; Pei Tong; Hai Qi; Meng Michelle Xu*; Wanli Liu*; Progressive polyadenylation and m6A modification of Ighg1 mRNA maintain IgG1 antibody homeostasis in antibody-secreting cells, Immunity, 2024, 57(11): 2547-2564

2) Yi Liu#; Guanghao Liang#; Hongjiao Xu#; Wenxin Dong#; Ze Dong#; Zhiwei Qiu; Zihao Zhang;Fangle Li; Yue Huang; Yilin Li; Jun Wu; Shenyi Yin; Yawei Zhang; Peijin Guo; Jun Liu; Jianzhong Jeff Xi; Peng Jiang; Dali Han*; Cai-Guang Yang*; Meng Michelle Xu*; Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance, Cell Metabolism, 2021, 33(6): 1221-1233

3) Lihui Dong#; Chuanyuan Chen#; Yawei Zhang#; Peijin Guo; Zhenghang Wang; Jian Li; Yi Liu; Jun Liu; Renbao Chang; Yilin Li; Guanghao Liang; Weiyi Lai; Mengxue Sun; Urszula Dougherty; Marc B. Bissonnette; Hailin Wang; Lin Shen; Meng Michelle Xu*; Dali Han*; The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth, Cancer Cell, 2021, 39(7): 945-957.E10

4) Dali Han#*; Jun Liu#; Chuanyuan Chen; Lihui Dong; Yi Liu; Renbao Chang; Xiaona Huang; Yuanyuan Liu; Jianying Wang; Urszula Dougherty; Marc B. Bissonnette; Bin Shen; Ralph R. Weichselbaum; Meng Michelle Xu*; Chuan He*; Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells, Nature, 2019, 566: 270-274

5) Meng Michelle Xu; Yang Pu; Dali Han; Yaoyao Shi; Xuezhi Cao; Hua Liang; Xiang Chen; Xiao-Dong Li; Liufu Deng; Zhijian J. Chen; Ralph R. Weichselbaum; Yang-Xin Fu; Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein alpha Signaling, Immunity, 2017, 47(2): 363-373

6) Xiaojuan Liu#; Yang Pu; Kyle Cron; Liufu Deng; Justin Kline; William A. Frazier; Hairong Xu; Hua Peng; Yang-Xin Fu*; Meng Michelle Xu#; CD47 blockade triggers T cell-mediated destruction of immunogenic tumors, Nature Medicine, 2015, 21(10): 1209-15

其他论文：

7) Menghao You; Jingjing Liu; Jie Li; Ce Ji; Haochen Ni; Wenhui Guo; Jiarui Zhang; Weiwei Jia; Zhao Wang; Yajiao Zhang; Yingpeng Yao; Guotao Yu; Huanyu Ji; Xiaohu Wang; Dali Han; Xuguang Du*; Meng Michelle Xu*; Shuyang Yu*; Mettl3-m6A-Creb1 forms an intrinsic regulatory axis in maintaining iNKT cell pool and functional differentiation, Cell Reports, 2023, 42(6):112584

8) Meng Xu#; Mingyue Liu#; Xuexiang Du; Sirui Li; Hang Li; Xiaozhu Li; Ying Li; Yang Wang; Zhihai Qin; Yang-Xin Fu*; Shengdian Wang*; Intratumoral Delivery of IL-21 Overcomes Anti- Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype, Journal of Immunology, 2015, 194(10): 4997-5006

9) Meng Xu; Xuexiang Du; Mingyue Liu; Sirui Li; Xiaozhu Li; Yang-Xin Fu*; Shengdian Wang*; The tumor immunosuppressive microenvironment impairs the therapy of anti-HER2/neu antibody, Protein & Cell, 2012, 3(6): 441-449

10) Xiaofei Zhang; Tingting Cong; Lei Wei; Bixi Zhong; Xiaowo Wang; Jin Sun; Shuxia Wang; Meng Michelle Xu; Ping Zhu*; Hong Jiang*; Jianwei Wang*; YTHDF3 modulates hematopoietic stem cells by recognizing RNA m6A modification on Ccnd1, Haematologica, 2022, 107(10)

11) Yuzhu Hou; Hua Liang; Enyu Rao; Wenxin Zheng; Xiaona Huang; Liufu Deng; Yuan Zhang; Xinshuang Yu; Meng Xu; Helena Mauceri; Ainhoa Arina; Ralph R. Weichselbaum*; Yang- Xin Fu*; Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy, Immunity, 2018, 49(3): 490

12) Hua Liang#; Liufu Deng#; Yuzhu Hou; Xiangjiao Meng; Xiaona Huang; Enyu Rao; Wenxin Zheng; Helena Mauceri; Matthias Mack; Meng Xu; Yang-Xin Fu*; Ralph R. Weichselbaum* ; Host STING-dependent MDSC mobilization drives extrinsic radiation resistance, Nature Communications, 2017, 8(1736)

13) Yang Pu; Meng Xu; Yong Liang; Kaiting Yang; Yajun Guo; Xuanming Yang *; Yang-Xin Fu*; Androgen receptor antagonists compromise T cell response against prostate cancer leading to early tumor relapse, Science Translational Medicine, 2016, 8(333): ra47

14) Dali Han#; Xingyu Lu#; Alan H. Shih#; Ji Nie; Qiancheng You; Meng Michelle Xu; Ari M. Melnick; Ross L. Levine*; Chuan He* ; A Highly Sensitive and Robust Method for Genome- wide 5hmC Profiling of Rare Cell Populations, Molecular Cell, 2016, 63(4): 711-719

15) Liufu Deng; Hua Liang; Meng Xu; Xuanming Yang; Byron Burnette; Ainhoa Arina; Xiao-Dong Li; Helena Mauceri; Michael Beckett; Thomas Darga; Xiaona Huang; Thomas F. Gajewski; Zhijian J. Chen; Yang-Xin Fu*; Ralph R. Weichselbaum*; STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors, Immunity, 2014, 41(5): 843-852

16) Liang Cheng#; Xuexiang Du#; Zheng Wang; Jianqi Ju; Mingming Jia; Qibin Huang; Qiao Xing; Meng Xu; Yi Tan; Mingyue Liu; Peishuang Du; Lishan Su*; Shengdian Wang*; Hyper-IL-15 suppresses metastatic and autochthonous liver cancer by promoting tumour-specific CD8(+) T cell responses, Journal of Hepatology, 2014, 61(6): 1297-1303

受邀综述：

17) Dali Han; Meng Michelle Xu; RNA Modification in the Immune System, Annual Review of Immunology, 2023, 41(1): 73-98

18) Meng Michelle Xu; Yuan Zhang; Yang-Xin Fu; The Role of Adaptive Immunity in the Efficacy of Targeted Cancer Therapies, Trends in Immunology, 2016, 37(2): 141-153

19) Meng Michelle Xu; Yang Pu; Ralph R. Weichselbaum *; Yang-Xin Fu*; Integrating conventional and antibody-based targeted anticancer treatment into immunotherapy, Oncogene, 2017, 36(5): 585-592

#共同第一作者

*共同通讯作者

经费支持（在研项目）:

1. 国家自然科学基金委员会, 重大项目, T2495272，TCR-T细胞的智能设计与高效合成， 2025-01-01至2029-12-31,444万元，在研，参与

2. 国家自然科学基金委员会, 重大项目, 22293052, 金属参与的免疫调控机制,2023-01-01 至 2027- 12-31, 528.6万元, 在研, 参与

经费支持（结题项目）

3. 国家自然科学基金委员会, 优秀青年科学基金项目, 81922054, 肿瘤免疫, 2020-01-01 至 2022-12- 31, 120万元, 结题, 主持

4. 国家自然科学基金委员会, 面上项目, 31870890, 信使RNA-m6A修饰对树突状细胞抗肿瘤免疫反应的调控机制研究, 2019-01-01 至 2022-12-31, 60万元, 结题, 主持

5. 北京市自然科学基金委员会, 重点研究专题, Z200023, 单细胞解析消化道肿瘤中免疫细胞功能耗竭的机制和免疫治疗策略, 2020-10 至 2024-10, 300万元, 结题, 主持

奖励及荣誉

2019年 国家优秀青年基金获得者