教育背景
1980-1984 甘肃农业大学兽医系，学士
1993-1997 美国得克萨斯大学微生物系，博士
工作经历
1987-1991 北京农业大学，讲师
1998-2000 美国St. Jude 儿童研究医院，博士后
2000-2005 美国Albany 医学院，助理教授
2005-2010 美国Albany 医学院，副教授
2010-2016 清华大学医学院，教授，院长助理2016-2020 清华大学医学院，教授，副院长2020-2024 清华大学医学院，教授
2024-至今 清华大学基础医学院，教授
研究领域
长期从事细菌性传染病致病机制与防控策略的研究。主要研究急性细菌感染性疾病发病的分子机制。急性细菌性肺炎、败血症等感染性疾病是当今世界范围内导致儿童和老年人死亡的最重要原因之一，其主要病原体包括肺炎链球菌、肺炎克雷伯菌、大肠埃希菌（Escherichia coli）、金黄色葡萄球菌等。 尽管人体的天然免疫系统（如吞噬性白细胞、补体、抗菌肽等）能够发现、捕捉并消灭非致病菌，但是在面对高毒力菌株或机体免疫功能低下时无法彻底清除病原体。因此，病原体在体内成功逃逸宿主天然免疫监控并大量增殖是导致急性肺炎及败血症的主要根源，然而目前在国际范围内对发病的分子机制缺乏理解。值得一提的是，日益增强的细菌耐药已经使过去用于治疗细菌感染的许多抗生素不再有效。据此，本实验室目前的主要科学问题包括：1） 病原菌依赖哪些自身的基因及其相关功能来达到逃逸宿主天然免疫监控的目的；2） 人体的哪些免疫细胞和免疫分子在清除非致病菌中发挥作用，却容忍致病菌的生存与繁殖。解决这些重大科学问题将为急性细菌感染性疾病的精准诊断、治疗和预防提供新的分子靶标与思路。
科学贡献
近年来的主要学术贡献包括：
1）揭示了荚膜多糖介导病原细菌逃逸肝脏巨噬细胞免疫监视的致病机制，颠覆了国际上普遍认为血液循环白细胞是荚膜免疫逃逸靶点的传统理论，为研究病原菌与宿主的感染-免疫互作机制开辟了新的领域，为研发新一代抗菌药物提供了最前沿的理论基础（Journal of Experimental Medicine 2022, 2025；PLoS Pathogens 2022；Science Advances 2025）。
2)发现了肝脏在疫苗免疫保护中清除血流致病菌的关键功能，颠覆了领域对疫苗保护机制的主流理论（Science Translational Medicine 2023）；提出了以肝脏免疫为核心的新型疫苗评价系统，得到国内外多家疫苗企业的广泛关注，开展了一系列与疫苗研发相关的合作研究（Vaccine 2024）。
3）发现了控制病原体共生与致病状态可逆性转换的表观遗传调控机制，为理解微生物如何适应复杂多变的宿主环境提供了科学依据(PLoS Pathogens 2016, 2020, 2024; Nucleic Acids Research 2020; Journal of Bacteriology 2019)。
荣誉奖励
2024国务院政府特殊津贴
2007基金委国家杰出青年
2007美国得克萨斯大学系统创新与创业奖
1997 美国微生物学会Raymond W. Sarber 奖
1997 美国得克萨斯大学校长奖
代表性论文 (*通讯作者)
1. An, Haoran*, Huang Yijia , Zhifeng Zhao, Kunpeng Li, Xueting Huang, Xianbin Tian, Jingjing Meng, Hongyu Zhou, Jiamin Wu, Qionghai Dai*, and Jing-Ren Zhang*. 2025. Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae from the blood circulation of mice. Science Advances, 11:eadq6399. https://doi.org/10.1126/sciadv.adq6399.
2. Tian, Xianbin, Yanni Liu, Kun Zhu, Haoran An, Jie Feng, Linqi Zhang, and Jing-Ren Zhang*. 2025. Natural antibodies to polysaccharide capsules enable Kupffer cells to capture invading bacteria in the liver sinusoids. Journal of Experimental Medicine, 222:e20240735, https://doi.org/10.1084/jem.20240735.
3. Zhang, Fan, Haoze Chen, Bo Zheng, Liang Huang, Ye Xiang, Jing-Ren Zhang, and Jiafeng Liu*. 2025. Heat stress induced bacterial tolerance against phage facilitates the evolution of Resistance. eLife, https://doi.org/10.7554/eLife.105703.1.
4. Chen, Hongyan, Jing-Ren Zhang*, Zongmin Du*, and Ruifu Yang*. Implications of the gppA Frameshift for Bacterial Survival in Human Macrophage. Emerging Microbes and Infections, in press.
5. Li, Yuelong, Xueting Huang, Qian Jin, Jianlong Wang, Jing-Ren Zhang*, and Haifa Zheng*. 2025. Critical quality attributes and manufacturing techniques for Streptococcus2 pneumoniae capsular polysaccharide in pneumococcal vaccines: A review. Carbohydrate Polymer Technologies and Applications, 9(2025):100733, https://doi.org/10.1016/j.carpta.2025.100733.
6. Wang, Shaomeng, Shaomeng Wang, Xiu-Yuan Li, Mengran Zhu, Haiteng Deng, Juanjuan Wang*, and Jing-Ren Zhang*. 2024. The SpxA1-TenA toxin-antitoxin system regulates epigenetic variations of Streptococcus pneumoniae by targeting protein synthesis. PLOS Pathogens, 20(12): e101280, https://doi.org/10.1371/journal.ppat.1012801.
7. Wang, Lijun, Qian Jin，Yanni Liu, Xueting Huang, Jing-Ren Zhang*, and Hui Wu*. 2024. A novel esterase regulates Klebsiella pneumoniae hypermucoviscosity and virulence. PLOS Pathogens, 20(10): e1012675, https://doi.org/10.1371/journal.ppat.1012675.
8. Tian, Xianbin, Juanjuan Wang*, Haoze Chen, Ming Ding, Qian Jin, and Jing-Ren Zhang*. 2024. In vivo functional immunoprotection correlates for vaccines against invasive bacteria. Vaccine, 42: 853-863. https://doi.org/10.1016/j.vaccine.2024.01.018.
9. Chen, Danyu, Jiao Hu, Mengran Zhu, Yufeng Xie, Hantian Yao, Haoran An, Yumin Meng, Juanjuan Wang, Xueting Huang, Zhujun Shao, Ye Xiang, Jianxun Qi, George Fu Gao, and Jing-Ren Zhang*. 2024. C-reactive protein drives potent clearance of blood bacteria in the liver by activating the complement system. bioRxiv, https://doi.org/10.1101/2024.10.05.616753.
10. Fang, Yujie, Wenxia Ma, Chenyun Qian, Jiao Hu, Xianbin Tian, Xueting Huang, Wenlong Lai, Li Wu, Haoran An, and Jing-Ren Zhang*. 2024. Influenza virus enhances bacterial growth in the lungs through weakening capsule receptor-mediated bacterial capture by neutrophils. bioRxiv, https://doi.org/10.1101/2024.11.08.622589.
11. Li, Yuelong, Hantian Yao, Yanli Liu, Xueting Huang, Xin Cao, Jianlong Wang, Zhixin Gao, Haifa Zheng, Jing-Ren Zhang*, and Jiankai Liu*. 2024. Simplified process for preparing native and depolymerized capsular polysaccharides of Streptococcus pneumoniae. Carbohydrate Polymers, 351: 123070. https://doi.org/10.1016/j.carbpol.2024.123070.
12. Li, Yuelong, Xin Cao, Xueting Huang, Yanli Liu, Jianlong Wang, Qian Jin, Jiankai Liu, Jing-Ren Zhang*, Haifa Zheng*. 2024. Novel manufacturing process of pneumococcal capsular polysaccharides using advanced sterilization methods. Frontiers in Bioengineering and Biotechnology, 12:1451881. https://doi.org/10.3389/fbioe.2024.1451881.
13. Sun, Wenbo, Tingyu Yang , Fengming Sun, Panhong Liu, Ji Gao, Xianmei Lan, Wei Xu, Yuhong Pang, Tong Li, Cuifeng Li, Qingtai Liang, Haoze Chen, Xiaohang Liu, Wenting Tan, Huanhuan Zhu, Fang Wang, Fanjun Cheng, Wei Wei Zhai, Han-Na Kim, Jing-Ren Zhang, Linqi Zhang, Lu Lu, Qiaoran Xi, Guohong Deng, Yanyi Huang, Xin Jin, Xiangjun Chen, and Wanli Liu*. 2024. An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms. Nature Immunology, 25:1809-1819. https://doi.org/10.1038/s41590-024-01944-4.
14. Suo, Zhaotaize, Ying Yu, Fangyun Shi, Jijing Tian, Zhihui Hao*, Jing-Ren Zhang and Jun Zou. Effects of oral liquiritigenin inoculation on gut microbiota and gene expression in intestinal and extraintestinal tissues of mice. Frontiers in Microbiomes, 3:1380152. https://doi.org/10.3389/frmbi.2024.1380152.
15. Li, Cuifeng, Meng Zhao , Xiaohang Liu , Bihua Xu , Lina Zhou , Xiaolin Sun , Yuxin Li , Wenbo Sun , Na Kang , Zhenglin Ji , Tong Li , Haoran An , Fei Wang , Chuan Wu , Jing-Ren Zhang , Qingwen Wang , Xiaodong Zhao , Zhanguo Li and Wanli Liu. 2024. Ion channel TRPV2 is critical in enhancing B cell activation and function. Journal of Experimental Medicine, 221: e20221042. https://doi.org/10.1084/jem.20221042.
16. Zhang, Yaxuan, Hui Qiu, Fuyu Duan, Haoran An, Huimin Qiao, Xingwu Zhang, Jing-Ren Zhang, Qiang Ding, Jie Na*. 2024. A comparative study of human pluripotent stem cell-derived macrophages in modeling viral infections. Viruses 16:552. https://doi.org/10.3390/v16040552.
17. Wang, Juanjuan, Haoran An, Ming Ding, Yanhong Liu, Shaomeng Wang, Qian Jin, Qi Wu, Haodi Dong, Qile Guo, Xianbin Tian, Jiankai Liu, Jingfei Zhang, Tao Zhu, Junqiang Li, Zhujun Shao, David E. Briles, Jan-Willem Veening, Haifa Zheng*, Linqi Zhang*, and Jing-Ren Zhang*. 2023. Liver macrophages and sinusoidal endothelial cells execute vaccine-elicited capture of invasive bacteria. Science Translational Medicine 15:eade0054. https://www.science.org/doi/10.1126/scitranslmed.ade0054.
18. Wang, Lijun, Xueting Huang, Qian Jin, Tang jie, Zhang Hua, Jing-Ren Zhang*, and Hui Wu*. 2023.Two-component response regulator OmpR regulates mucoviscosity through energy metabolism in Klebsiella pneumoniae. Microbiology Spectrum 11(3):e0054423. https://doi.org/10.1128/spectrum.00544-23.
19. Zhang, Chengwang, Yanhong Liu, Haoran An, Xueying Wang, Lina Xu, Haiteng Deng, Songquan Wu, Jing-Ren Zhang*, and Xiaohui Liu*. 2023. Amino acid starvation-induced glutamine accumulation enhances pneumococcal survival. mSphere 8(3):e00625-22. https://doi.org/10.1128/msphere.00625-22.
20. An, Haoran, Xianbin Tian, Yijia Huang, and Jing-Ren Zhang*. 2023. Identification of the mouse Kupffer cell receptors recognizing pneumococcal capsules by affinity screening. Star Protocols 4(1). https://doi.org/10.1016/j.xpro.2023.102065.
21. Zhang, Howard, Ziyuan Zhang, Bert L. Shan, Xianbin Tian, Qing Meng, and Jing-Ren Zhang*. 2023. Varying levels of disinfectant resistance among invasive Klebsiella pneumoniae isolates. Journal of Emerging Investigators 6:1-6. DOI: https://doi.org/10.59720/22-251.
22. Zeng, Yuan, Yuqin Song, Langing Cui, Qi Wu, Chao Wang, Adriano Cappellazzo Coelho, Gang Zhang, Dawei Wei, Chao Li, Jing-Ren Zhang, Jacques Corbeil, Yun Li*, and Jie Feng*. 2023. Phylogenomic insights into evolutionary trajectories of multidrug resistant S. pneumoniae CC271 over a period of 14 years in China. Genome Medicine 15:46. https://doi.org/10.1186/s13073-023-01200-8.
23. Liu, Congcong, Ning Dong, Xueting Huang, Zixian Huang, Chang Cai, Jiayue Lu, Hongwei Zhou, Jing-Ren Zhang, Yu Zeng, Fan Yang, Gongxiang Chen, Zhangqi Shen*, Rong Zhang*, and Sheng Chen*. 2023. Emergence of the clinical rdar morphotype carbapenem-resistant and hypervirulent Klebsiella pneumoniae with enhanced adaption to hospital environment. Science of the Total Environment 889(1). https://doi.org/10.1016/j.scitotenv.2023.164302.
24. An, Haoran, Chenyun Qian, Yijia Huang, Jing Li, Xianbin Tian, Jiaying Feng, Jiao Hu, Yujie Fang, Fangfang Jiao, Yuna Zeng, Xueting Huang, Xianbin Meng, Xue Liu, Xin Lin, Zhutian Zeng, Martin Guilliams, Alain Beschin, Yongwen Chen, Yuzhang Wu, Jing Wang, Marco R. Oggioni, John M. Leong, Jan-Willem Veening, Haiteng Deng, Rong Zhang, Hui Wang, Jiang Wu, Yan Cui, and Jing-Ren Zhang*. 2022. Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria. Journal of Experimental Medicine 219:e20212032. https://doi.org/10.1084/jem.20212032.
25. Huang, Xueting, Xiuyuan Li, Haoran, Juanjuan Wang, Ming Ding, Lijun Wang, Lulu Li, Quanjiang Ji, Fen Qu, Hui Wang, Yingchun Xu, Xinxin Lu, Yuan He, and Jing-Ren Zhang*. 2022. Capsule type defines the capacity of Klebsiella pneumoniae in evading Kupffer cell capture in the liver. PLOS Pathogens 18:e1010693. https://doi.org/10.1371/journal.ppat.1010693.
26. Zhou, Menglan, Ziran Wang, Li Zhang, Timothy Kudinha, Haoran An, Chenyun Qian, Jiang Bin, Yao Wang, Ying-Chun Xu, Zhengyin Liu*, Hong Zhang*, and Jing-Ren Zhang*. 2022. Serotype distribution, antimicrobial susceptibility, multilocus sequencing type and virulence of invasive Streptococcus pneumoniae in China: a six-year multi-center study. Frontiers in Microbiology 12:798750. DOI:10.3389/fmicb.2021.798750.
27. Guo, Ziyi, Haoqi Yang, Jing-Ren Zhang, Wenwen Zeng*, and Xiaoyu Hu*. 2022. Leptin receptor signaling sustains metabolic fitness of alveolar macrophages to attenuate pulmonary inflammation. Science Advances. 8:eabo3064. DOI:10.1126/sciadv.abo3064.
28. Hu, Qingqing, Huichun Tong, Jing Wang, Pupu Ge, Lin Zhu, Cuihua Liu, Jing-Ren Zhang, Xiuzhu Dong. 2021. A novel aquaporin subfamily imports oxygen and contributes to pneumococcal virulence by controlling production and release of virulence factors. mBio 12:e01309-21. https://doi.org/10.1128/mBio.01309-21.
29. Zhang, Chengwang, Haoran An, Jiao Hu, Jing Li, Wenhao Zhang, Xun Lan, Haiteng Deng, and Jing-Ren Zhang*. 2021. MetR is a molecular adaptor for pneumococcal carriage in the healthy upper airway. Molecular Microbiology 116:438-458. DOI:10.1111/MMI.14724.
30. Huang, Xueting, Juanjuan Wang, Jing Li, Yanni Liu, Xue Liu, Zeyao Li, Kurni Kurniyati, Yijie Deng, Guilin Wang, Joseph D. Ralph, Megan De Ste Croix, Sara Escobar-Gonzalez, Richard J. Roberts, Jan-Willem Veening, Xun Lan, Marco R. Oggioni*, Chunhao Li*, and Jing-Ren Zhang*. 2020. Prevalence of phase variable epigenetic invertons among host-associated bacteria. Nucleic Acids Research 48:11468-11485. https://doi.org/10.1093/nar/gkaa907.
31. Wang, Juanjuan, Jing-Wen Li, Yijia Huang, Shaolin Wang, and Jing-Ren Zhang*. 2020. Regulation of pneumococcal epigenetic and colony phases by multiple two-component regulatory systems. PLOS Pathogens 16 (3):e1008417. https://doi.org/10.1371/journal.ppat.1008417.
32. Li, Jing.-Wen, Juanjuan Wang, Sofia Ruiz-Cruz, Manuel Espinosa, Jing-Ren Zhang*, and Alicia Bravo*. 2020. In vitro DNA inversions mediated by the PsrA site-specific tyrosine recombinase of Streptococcus pneumoniae. Frontiers in Molecular Biosciences 7:43. DOI:10.3389/fmolb.2020.00043.
33. Li, Jing-Wen, Jing Li, Juanjuan Wang, Chunhao Li, and Jing-Ren Zhang*. 2019. Molecular mechanisms of hsdS inversions in the cod locus of Streptococcus pneumoniae. Journal of Bacteriology 201(6):e00581-18. https://doi.org/10.1128/jb.00581-18. Chosen by the editor as the Article of Significant Interest in This Issue, DOI:10.1128/JB.00023-19.
34. Liu, Yanni, Yuna Zeng, Yijia Huang, Gu L, Shaolin Wang, Chunhao Li, Donald A. Morrison, Haiteng Deng*, Jing-Ren Zhang*. 2019. HtrA‐mediated selective degradation of DNA uptake apparatus accelerates termination of pneumococcal transformation. Molecular Microbiology 112：1308-1325. DOI:10.1111/mmi.14364.
35. Li, Jing and Jing-Ren Zhang*. 2019. Phase variation of Streptococcus pneumoniae. Microbiology Spectrum 7(1). DOI:10.1128/microbiolspec.GPP3-0005-2018.
36. Zong, Yu, Fang Fang, Kirsten J. Meyer, Liguo Wang, Zhihao Ni, Hongying Gao. Kim Lewis, Jing-Ren Zhang, and Yu Rao. 2019. Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics. Nature Communications 10:3268. DOI:10.1038/s41467-019-11211-y.
37. Zhang, Kai, Zhuan Qin, Yunjie Chang, Jun Liu, Michael G. Malkowski, Saimtun Shipa, Li Li, Weigang Qiu, Jing-Ren Zhang, and Chunhao Li*. 2019. Analysis of a flagellar filament cap mutant reveals that HtrA serine protease degrades unfolded flagellin protein in the periplasm of Borrelia burgdorferi. Molecular Microbiology 111:1652-1670. DOI:10.1111/mmi.14243.
38. Wang, Xu, Yuna Zeng, Li Sheng, Peter Larson, Xue Liu, Xiaowen Zou, Shufang Wang, Kaijing Guo, Chen Ma, Gang Zhang, Huaqing Cui, David Ferguson, Yan Li, Jing-Ren Zhang*, and Courtney Aldrich*. 2019. A cinchona alkaloid antibiotic that appears to target ATP synthase in Streptococcus pneumoniae. Journal of Medicinal Chemistry 62:2305-2332. DOI:10.1021/acs.jmedchem.8b01353.
39. Wang, Yang, Zhensong Wen, Xiaolei Pan, David E. Briles, Yongqun He, and Jing-Ren Zhang*. 2018. Novel immunoprotective proteins of Streptococcus pneumoniae identified by opsonophagocytosis killing screen. Infection and Immunity 86(9):e00423-18. DOI: 10.1128/IAI.00423-18.
40. He, Lihong, Dongyang Luo, Fan Yang, Chunhao Li, Xuegong Zhang, Haiteng Deng, and Jing-Ren Zhang*. 2018. Multiple domains of bacterial and human Lon proteases define substrate selectivity. Emerging Microbes and Infections:149. DOI:10.1038/s41426-018-0148-4.
41. Kurniyati, Kurni, Jun Liu, Jing-Ren Zhang, Yunjiang Min, and Chunhao Li*. 2018. A pleiotropic role of FlaG homolog in regulating the cell morphogenesis and flagellar homeostasis at the cell poles of Treponema denticola. Cellular Microbiology 21:e12886. DOI:10.1111/cmi.12886.
42. Pan, Yushan *, Haoran An, Tong Fu, Shiyu Zhao, Chengwang Zhang, Genhui Xiao, Jing-Ren Zhang, Xinfang Zhao, Gongzheng Hu*. 2018. Characterization of Streptococcus pluranimalium from a cattle with mastitis by whole genome sequencing and functional validation. BMC Microbiology 18:182. DOI:10.1186/s12866-018-1327-0
43. Xu, Miao, Huiping Lu, Young-Hee Lee, Y. Wu, Kewei Liu, Yuling Shi, Haoran An, Jing-Ren Zhang, Xiaohu Wang, Yuping Lai, and Chen Dong*. 2018. An Interleukin-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation. Immunity 48:787-798 e4. DOI:10.1016/j.immuni.2018.03.019.
44. Liu, Xue, Jing-Wen Li, Zhixin Feng, Yongfu Luo, Jan-Willem Veening, and Jing-Ren Zhang*. 2017. Transcriptional repressor PvtR regulates phenotypic tolerance to vancomycin in Streptococcus pneumoniae. Journal of Bacteriology 199(14). pii:e00054-17. DOI:10.1128/JB.00054-17.
45. Li, Jing, Juanjuan Wang, Fangfang Jiao and Jing-Ren Zhang*. 2017. Observation of pneumococcal phase variation in colony morphology. Bio-protocol 7:Iss15. DOI:10.21769/BioProtoc.2434.
46. Yu, Yuanyuan, Jing-Wen Li, Long Jiang, Jing-Ren Zhang*, and Liansuo Zu*. 2017. Catalytic enantioselective aza-pinacol rearrangement. Angewandte Chemie International Edition English 56:9217-9221. DOI:10.1002/anie.201705539.
47. Chen, Fei, Guolin Cui, Shuxia Wang, Manoj K. Mohan Nair, Lihong He, Xinyi Qi, Xiangmin Han, Hanqi Zhang, Jing-Ren Zhang*, and Jingliang Su*. 2017. Outer membrane vesicle-associated lipase FtlA enhances cellular invasion and virulence in Francisella tularensis LVS. Emerging Microbes and Infections 6:e66. DOI:10.1038/emi.2017.53.
48. Liu, Bo, Xue Liu, Jing-Ren Zhang*, and Gang Liu*. 2017. A natural lipotrisaccharide and its derivatives selectively lyse Streptococcus pneumoniae via interaction with cell membrane. ACS Infectious Diseases 3:438-453. DOI:10.1021/acsinfecdis.7b00008.
49. Liu, Xue, Clement Gallay, Morten Kjos, Amau Domenech, Jelle Slager, Sebastiaan P. van Kessel, Kevin Knoops, Robin A. Sorg, Jing-Ren Zhang, and Jan-Willem Veening*. 2017. High-throughput CRISPRi phenotyping in Streptococcus pneumoniae identifies new essential genes involved in cell wall synthesis and competence development. Molecular Systems Biology 13:931. DOI:10.15252/msb.20167449.
50. Li, Jing Jing-Wen Li, Zhixin Feng, Juanjuan Wang, Haoran An, Yanni Liu, Yang Wang, Kailing Wang, Xuegong Zhang, Zhun Miao, Wenbo Liang, Robert Sebra, Guiling Wang, Wen-Ching Wang, and Jing-Ren Zhang*. 2016. Epigenetic switch driven by DNA inversions dictates phase variation in Streptococcus pneumoniae. PLOS Pathogens 12: e1005762. https://doi.org/10.1371/journal.ppat.1005762. Highlighted in Nature Reviews Microbiology DOI:10.1038/nrmicro.2016.122.
51. Wen, Zhensong, Yanni Liu, Fen Qu, and Jing-Ren Zhang*. 2016. Allelic variation of the capsule promoter diversifies encapsulation and virulence in Streptococcus pneumoniae. Scientific Reports 6:30176. DOI: 10.1038/srep30176.
52. Li, Guilin, Zhuowen. Liang, Xiatai Wang, Yonghong Yang, Zhujun Shao, Ma Li, Yueyun Ma, Fen Qu, Donald A. Morrison, and Jing-Ren Zhang*. 2016. Addiction of hyper-transformable pneumococcal isolates to natural transformation for in vivo fitness and virulence. Infection and Immunity 84:1887-1901. DOI:10.1128/IAI.00097-16.
53. He, Lihong, Manoj K. Mohan Nair, Yuling Chen, Xue Liu, Mengyun Zhang, Karsten R. O. Hazlett, Haiteng Deng*, and Jing-Ren Zhang*. 2016. The protease locus of Francisella tularensis LVS is required for stress tolerance and infection of mammalian host. Infection and Immunity 84:1387-402. DOI:10.1128/IAI.00076-16.
54. Bai, Xiao-Hui, Qiong Li, Yong-Liang Jiang, Jing-Ren Zhang*, Yuxin Chen*, and Cong-Zhao Zhou*. 2016. Structural comparison and simulation of pneumococcal peptidoglycan hydrolase LytB. Methods in Molecular Biology 1440:271-83. DOI:10.1007/978-1-4939-3676-2_19.
55. Yang, Hongzhi, Xue Liu, Qingong Li, Longbo Li, Jing-Ren Zhang*, and Yefeng Tang*. 2016. Total synthesis and preliminary SAR study of (+/-)-merochlorins A and B. Organic & Biomolecular Chemistry 14:198-205. DOI: 10.1039/c5ob01946j.
56. Yang, Tao, Gong Chen, Zitai Sang, Yuanyuan Liu, Xiaoyan Yang, Ying Chang, Haiyue Long, Wei Ang, Jianying Tang, Zhenling Wang*, Guobo Li, Shengyong Yang, Jing-Ren Zhang, Yuquan Wei, and Youfu Luo*. 2015. Discovery of a teraryl oxazolidinone compound (S)-N-((3-(3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5 -yl)methyl)acetamide phosphate as a novel antimicrobial agent with enhanced safety profile and efficacies. Journal of Medical Chemistry 58:6389-409. DOI: 10.1021/acs.jmedchem.5b00152.
57. Wang, Lei, Yong-Liang Jiang, Jing-Ren Zhang, Cong-Zhao Zhou, and Yuxin Chen*. 2015. Structural and enzymatic characterization of the choline kinase LicA from Streptococcus pneumoniae. PLoS One 10:e0120467. DOI:10.1371/journal.pone.0120467.
58. Wen, Zhensong, Odeniel Sertil, Yongxin Chen, Shanshan Zhang, Xue Liu, Wen-Ching Wang, and Jing-Ren Zhang*. 2015. The sequence elements upstream of the core promoter are necessary for the full transcription of the capsule gene operon in Streptococcus pneumoniae strain D39. Infection and Immunity 83:1957-1972. DOI:10.1128/IAI.02944-14.
59. Achila, David, Aizhou Liu, Rahui Banerjee, Yue Li, Erik Martinez-Hackert, Jing-Ren Zhang*, and Honggao Yan*. 2015. Structural determinants of host specificity of complement factor H recruitment by Streptococcus pneumoniae. Biochemical Journal 465:325-335. DOI:10.1042/BJ20141069.
60. Feng, Zhixin., Jing Li, Jing-Ren Zhang*, and Xuegong Zhang*. 2014. qDNAmod: a statistical model based tool to reveal intercellular heterogeneity of DNA modification from SMRT sequencing data. Nucleic Acids Research 42:13488-13499. https://doi.org/10.1093/nar/gku1097.
61. Zhu, Deyu, Lijun Wang, Guijun Shang, Xue Liu, Jing Zhu, Defen Lu, Lei Wang, Biao Kan, Jing-Ren Zhang, and Ye Xiang. 2014. Structural biochemistry of a Vibrio cholerae dinucleotide cyclase reveals cyclase activity regulation by folates. Molecular Cell 55:931-937. DOI:10.1016/j.molcel.2014.08.001.
62. Zeng Xian-Fei, Yueyun Ma, Liu Yang, Lei Zhou, Yijun Xin, Liang Chang, Jing-Ren Zhang, and Xiaoke Hao*. 2014. A C-terminal truncated mutation of licC attenuates the virulence of Streptococcus pneumoniae. Research in Microbiololgy 165: 630-638. DOI:10.1016/j.resmic.2014.09.002.
63. Song, Yongxiang, Qinglian Li, Xue Liu, Yuchan Chen, Yun Zhang, Aijun Sun, Weimin Zhang, Jing-Ren Zhang, and Jianhua Ju*. 2014. Cyclic hexapeptides from the deep South China Sea-derived Streptomyces scopuliridis SCSIO ZJ46 active against pathogenic Gram-positive bacteria. Journal of Natural Products 77:1937-1941. DOI:10.1021/np500399v.
64. Bai, Xiao-Hui, Hui-Jie Chen, Yong-Liang Jiang, Zhensong Wen, Yubin Huang, Wang Cheng, Qiong Li, Lei Qi, Jing-Ren Zhang*, Yuxin Chen*, and Cong-Zhao Zhou*. 2014. Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis. Journal of Biological Chemistry 289:23403–23416. DOI:10.1074/jbc.M114.579714.
65. Yang, Yi-Hu, Yong-Liang Jiang, Juan Zhang, Lei Wang, Xiao-Hui Bai, Shi-Jie Zhang, Yan-Min Ren, Na Li, Yonghui Zhang, Zhiyong Zhang, Qingguo Gong, Yide Mei, Ting Xue, Jing-Ren Zhang, Yuxin Chen*, and Cong-Zhao Zhou*. 2014. Structural insights into SraP-mediated Staphylococcus aureus adhesion to host cells. PLOS Pathogens 10:e1004169. DOI:10.1371/journal.ppat.1004169.
66. Pan, Xiaolei, Yang Yang, and Jing-Ren Zhang*. 2014. Molecular basis of host specificity in human pathogenic bacteria. Emerging Microbes and Infections 3:e23. DOI:10.1038/emi.2014.23.
67. Gupta, R., Jun Yang, Y. Dong, E. Swiatlo, Jing-Ren Zhang, Dennis W. Metzger, and Guangchun Bai*. 2013. Deletion of arcD in Streptococcus pneumoniae D39 impairs its capsule and attenuates virulence. Infection and Immunity 81:3903-3911.
68. Qaidi, Samir E., Jun Yang, Jing-Ren Zhang, Dennis W. Metzger, and Guangchun Bai*. 2013. The vitamin B6 biosynthesis pathway in Streptococcus pneumoniae is controlled by pyridoxal 5’-phosphate and the transcription factor PdxR, and impacts on ear infection. Journal of Bacteriology 195:2187-2196.
69. Li, Guilin, Fen Z. Hu, Xianwei Yang, Yujun Cui, Jun Yang, Fen Qu, George F. Gao, and Jing-Ren Zhang*. 2012. The complete genome sequence of Streptococcus pneumoniae strain ST556, a multi-drug resistant isolate from an otitis media patient. Journal of Bacteriology 194:3294-3295.
70. Han, Huiming, Cuihua Liu, Quanhui Wang, Chunling Xuan, Beiwen Zheng, Jiaqi Tang, Jinghua Yan, Jing-Ren Zhang, Ming Li, Hao Cheng, Guangwen Lu, George F. Gao*. 2012. The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism. Microbiology 158:1852-1866.
71. Su, J., J. Asare, J. Yang, M. Kumar, J. Mazurkiewicz, Y. Abu-Kwaik, and Jing-Ren Zhang*. 2011. The capBCA locus is required for intracellular growth of Francisella tularensis. Frontiers in Microbiology 2:83. DOI:10.3389/fmicb.2011.00083.
72. Zhang, Q., F. Gao, H. Peng, H. Cheng, Y. Liu, J. Tang, J. Thompson, G. Wei, Jing-Ren Zhang, Y. Du, J. Yan, and G.F. Gao*. 2009. Crystal structures of Streptococcus suis mannonate dehydratase (ManD) and its complex with substrate: genetic and biochemical evidence for a catalytic mechanism. Journal of Bacteriology 191:5832–5837.
73. Chen, Huaiqing, Yueyun Ma, Jun Yang, Christopher J. O'Brien, Scott L. Lee, Joseph E. Mazurkiewicz, Sauli Haataja, Jinghua Yan, George F. Gao, and Jing-Ren Zhang*. 2008. Genetic requirement for pneumococcal ear infection. PLoS One 3:e2950.
74. Lu, Ling, Zhuo Ma, T. Sakari Jokiranta, Adeline R. Whitney, Frank R. DeLeo, and Jing-Ren Zhang*. 2008. Species-specific interaction of Streptococcus pneumoniae with human complement factor H. Journal of Immunology 181:7138-7146.
75. Ma, Zhuo and Jing-Ren Zhang*. 2007. RR06 activates the transcription of spr1996 and cbpA in Streptococcus pneumoniae. Journal of Bacteriology 189:2497-2509.
76. Su, Jingliang, Jun Yang, Daimin Zhao, Thomas H. Kawula, Jeffery. A. Banas, and Jing-Ren Zhang*. 2007. Genome-wide identification of Francisella tularensis virulence determinants. Infection and Immunity 75:3089-3101.
77. Lu, Ling, Yueyun Ma, and Jing-Ren Zhang*. 2006. Streptococcus pneumoniae recruits complement factor H through the amino terminus of CbpA. Journal of Biological Chemistry 278:48178-48187.
78. Lu, Ling, Michael E. Lamm, Hongmin Li, Blaise Corthesy, and Jing-Ren Zhang*. 2003. The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4. Journal of Biological Chemistry 278:48178-48187.
79. Zhang, Jing-Ren, Keith E. Mostov, Michael E. Lamm, Masanobu Nanno, Shin-ichiro Shimida, Makoto Ohwaki, and Elaine Tuomanen*. 2000. The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells. Cell 102:827-837.
80. Zhang, Jing-Ren, Ilona Idanpaan-Heikkila, Werner Fischer, and Elaine Tuomanen*. 1999. Pneumococcal licD2 gene is involved in phosphorylcholine metabolism. Molecular Microbiology 31:1477-1488.
81. Zhang, Jing-Ren and Elaine Tuomanen*. 1999. Molecular and cellular mechanisms for microbial entry into the CNS. Journal of NeuroVirology 5:591-603.
82. Zhang, Jing-Ren and Steven J. Norris*. 1998. Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi. Infection and Immunity 66:3689-3697.
83. Zhang, Jing-Ren and Steven J. Norris*. 1998. Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion. Infection and Immunity 66:3698-3704.
84. Zhang, Jing-Ren, John. M. Hardham, Alan. G. Barbour, and Steven J. Norris*. 1997. Antigenic variation in Lyme disease Borrelia by promiscuous recombination of vmp-like sequence cassettes. Cell 89:275-285.
85. Dabbert, C. Brad, Robert L. Lockmiller*, Jing-Ren Zhang, Charles W. Qualls, and Kim Burnham. 1994. High in vitro endotoxin responsiveness of macrophage from an endotoxin-resistant wild rodent species, Sigmodon hispidus. Developmental and Comparative Immunology 18:147-153.
