教育背景
1981-1985 北京师范大学生物系 学士
1985-1988 北京师范大学生物系 硕士
1988-1992 英国爱丁堡大学遗传学系 博士
工作经历
1992-1993 英国爱丁堡大学遗传学系 博士后
1993-1998 纽约大学艾伦戴蒙德艾滋病研究中心 博士后
1998-2003 美国洛克菲勒大学艾伦戴蒙德艾滋病研究中心 助理教授
2003-2007 美国洛克菲勒大学艾伦戴蒙德艾滋病研究中心 副教授
2007-2024 清华大学医学院 教授
2024-至今 清华大学基础医学院 教授
研究领域
致力于病毒感染和保护性免疫机制的研究，免疫和基因治疗临床应用研发。在疫苗的设计与优化、保护性抗体反应机制及评估等方面取得关键突破，多个抗体和疫苗已经在国内外进入人体临床试验或批准上市。
科学贡献
在疫苗的免疫原设计与优化、载体的选择和构建、保护性抗体反应机制以及评估等方面取得了突出的成绩，多个抗体和疫苗已经在国内外进入人体临床试验。2021年12月8日，研发的新冠抗体药物获得国家药品监督管理局批准上市，实现我国新冠药物的零突破。创新型新冠鼻腔疫苗正在开展临床安全性和有效性研究，为预防新冠病毒感染和传播提供全新的手段和候选。发表200多篇高水平的科研论文，持续多年入选感染和免疫学科中国高被引学者。
荣誉奖励
2023 享受国务院政府特殊津贴专家
2022 北京市优秀研究生指导教师
2021 全国科技系统抗击新冠肺炎疫情先进个人
2021 清华大学第十七届“良师益友”
2021 中华预防医学会科学技术奖
2021 教育部中国高等学校十大科技进展
2020 万科讲席教授
2019 拜耳讲席教授
2016-至今 非洲科学院院士
2016 清华大学医学院十大重大成果
2016 清华大学教育教学成果一等奖
2015-2017 强生研究员
2015 国家科技进步奖二等奖
2008-至今 国家自然科学基金杰出青年基金
2007-至今 长江学者奖励计划特聘教授
2003-2006 国家自然科学基金海外杰出青年基金
2001-2002 葛兰素史克药物研发奖
1988-1992 中英友好奖学金
代表性论文
Wang J, An H, Ding M, Liu Y, Wang S, Jin Q, Wu Q, Dong H, Guo Q, Tian X, Liu J, Zhang J, Zhu T, Li J, Shao Z, Briles DE, Veening JW, Zheng H, Zhang L, Zhang JR. Liver macrophages and sinusoidal endothelial cells execute vaccine-elicited capture of invasive bacteria. Sci Transl Med. 2023 Dec 20;15(727):eade0054.
Wang R, Han Y, Zhang R, Zhu J, Nan X, Liu Y, Yang Z, Zhou B, Yu J, Lin Z, Li J, Chen P, Wang Y, Li Y, Liu D, Shi X, Wang X, Zhang Q, Yang YR, Li T, Zhang L. Dissecting the intricacies of human antibody responses to SARS-CoV-1 and SARS-CoV-2 infection. Immunity. 2023 Nov 14;56(11):2635-2649.
Ju B, Zhang Q, Wang Z, Aw ZQ, Chen P, Zhou B, Wang R, Ge X, Lv Q, Cheng L, Zhang R, Wong YH, Chen H, Wang H, Shan S, Liao X, Shi X, Liu L, Chu JJH, Wang X, Zhang Z, Zhang L. Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants. Nat Immunol. 2023 Apr;24(4):690-699.
Li Y, Wang Z, Hou Y, Liu X, Hong J, Shi X, Huang X, Zhang T, Liao X, Zhang L. Novel TLR7/8 agonists promote activation of HIV-1 latent reservoirs and human T and NK cells. Front Microbiol. 2023 Jan 27;14:1033448.
Li M, Ren Y, Aw ZQ, Chen B, Yang Z, Lei Y, Cheng L, Liang Q, Hong J, Yang Y, Chen J, Wong YH, Wei J, Shan S, Zhang S, Ge J, Wang R, Dong JZ, Chen Y, Shi X, Zhang Q, Zhang Z, Chu JJH, Wang X, Zhang L. Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses. Nat Commun. 2022 Dec 27;13(1):7957.
Zhang S, Jia W, Zeng J, Li M, Wang Z, Zhou H, Zhang L, Wang X. Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein. Front Microbiol. 2022 Sep 28;13:988298.
Ji Y, Zhang Q, Cheng L, Ge J, Wang R, Fang M, Mucker EM, Chen P, Ma J, Zhang R, Li C, Hammond H, Baracco L, Holbrook M, Frieman M, Zhang Z, Wang X, Hooper JW, Zhang L, Zhu Q. Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2. Front Immunol. 2022 Sep 14;13:980435.
Wang R, Zhang Q, Zhang R, Aw ZQ, Chen P, Wong YH, Hong J, Ju B, Shi X, Ding Q, Zhang Z, Chu JJH, Zhang L. SARS-CoV-2 Omicron Variants Reduce Antibody Neutralization and Acquire Usage of Mouse ACE2. Front Immunol. 2022 Jun 17;13:854952.
Qi H, Liu B, Wang X, Zhang L. The humoral response and antibodies against SARS-CoV-2 infection. Nat Immunol. 2022 Jul;23(7):1008-1020.
Liang Q, Wang Y, Zhang S, Sun J, Sun W, Li J, Liu Y, Li M, Cheng L, Jiang Y, Wang R, Zhang R, Yang Z, Ren Y, Chen P, Gao P, Yan H, Zhang Z, Zhang Q, Shi X, Wang J, Liu W, Wang X, Ying B, Zhao J, Qi H, Zhang L. RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants. iScience. 2022 Apr 15;25(4):104043.
Lan J, He X, Ren Y, Wang Z, Zhou H, Fan S, Zhu C, Liu D, Shao B, Liu TY, Wang Q, Zhang L, Ge J, Wang T, Wang X. Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction. Cell Res. 2022 Jun;32(6):593-595.
Zhang S, Liang Q, He X, Zhao C, Ren W, Yang Z, Wang Z, Ding Q, Deng H, Wang T, Zhang L, Wang X. Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2. Cell Res. 2022 Mar;32(3):315-318.
Shan S, Luo S, Yang Z, Hong J, Su Y, Ding F, Fu L, Li C, Chen P, Ma J, Shi X, Zhang Q, Berger B, Zhang L, Peng J. Deep learning guided optimization of human antibody against SARS-CoV-2 variants with broad neutralization. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2122954119.
Shan S, Mok CK, Zhang S, Lan J, Li J, Yang Z, Wang R, Cheng L, Fang M, Aw ZQ, Yu J, Zhang Q, Shi X, Zhang T, Zhang Z, Wang J, Wang X, Chu JJH, Zhang L. A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants. Front Immunol. 2021 Dec 13;12:766821.
Zhu QY, Shan S, Yu J, Peng SY, Sun C, Zuo Y, Zhong LY, Yan SM, Zhang X, Yang Z, Peng YJ, Shi X, Cao SM, Wang X, Zeng MS, Zhang L. A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus. Nat Commun. 2021 Nov 16;12(1):6624.
Zhang Q, Ju B, Ge J, Chan JF, Cheng L, Wang R, Huang W, Fang M, Chen P, Zhou B, Song S, Shan S, Yan B, Zhang S, Ge X, Yu J, Zhao J, Wang H, Liu L, Lv Q, Fu L, Shi X, Yuen KY, Liu L, Wang Y, Chen Z, Zhang L, Wang X, Zhang Z. Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nat Commun. 2021 Jul 9;12(1):4210.
Niu M, Wong YC, Wang H, Li X, Chan CY, Zhang Q, Ling L, Cheng L, Wang R, Du Y, Yim LY, Jin X, Zhang H, Zhang L, Chen Z. Tandem bispecific antibody prevents pathogenic SHIVSF162P3CN infection and disease progression. Cell Rep. 2021 Aug 24;36(8):109611.
Wang R, Zhang Q, Ge J, Ren W, Zhang R, Lan J, Ju B, Su B, Yu F, Chen P, Liao H, Feng Y, Li X, Shi X, Zhang Z, Zhang F, Ding Q, Zhang T, Wang X, Zhang L. Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species. Immunity. 2021 Jul 13;54(7):1611-1621.e5.
Li M, Guo J, Lu S, Zhou R, Shi H, Shi X, Cheng L, Liang Q, Liu H, Wang P, Wang N, Wang Y, Fu L, Xing M, Wang R, Ju B, Liu L, Lau SY, Jia W, Tong X, Yuan L, Guo Y, Qi H, Zhang Q, Huang Z, Chen H, Zhang Z, Chen Z, Peng X, Zhou D, Zhang L. Single-Dose Immunization With a Chimpanzee Adenovirus-Based Vaccine Induces Sustained and Protective Immunity Against SARS-CoV-2 Infection. Front Immunol. 2021 Jun 28;12:697074.
Yan R, Wang R, Ju B, Yu J, Zhang Y, Liu N, Wang J, Zhang Q, Chen P, Zhou B, Li Y, Shen Y, Zhang S, Tian L, Guo Y, Xia L, Zhong X, Cheng L, Ge X, Zhao J, Wang HW, Wang X, Zhang Z, Zhang L, Zhou Q. Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Res. 2021 May;31(5):517-525.
Zhang S, Qiao S, Yu J, Zeng J, Shan S, Tian L, Lan J, Zhang L, Wang X. Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution. Nat Commun. 2021 Mar 11;12(1):1607.
Ge J, Zhang S, Zhang L, Wang X. Structural basis of severe acute respiratory syndrome coronavirus 2 infection. Curr Opin HIV AIDS. 2021 Jan;16(1):74-81.
Ge J, Wang R, Ju B, Zhang Q, Sun J, Chen P, Zhang S, Tian Y, Shan S, Cheng L, Zhou B, Song S, Zhao J, Wang H, Shi X, Ding Q, Liu L, Zhao J, Zhang Z, Wang X, Zhang L. Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry. Nat Commun. 2021 Jan 11;12(1):250.
Ju B, Zhang Q, Ge J, Wang R, Sun J, Ge X, Yu J, Shan S, Zhou B, Song S, Tang X, Yu J, Lan J, Yuan J, Wang H, Zhao J, Zhang S, Wang Y, Shi X, Liu L, Zhao J, Wang X, Zhang Z, Zhang L. Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature. 2020 Aug;584(7819):115-119.
Wang Q, Ma B, Liang Q, Zhu A, Wang H, Fu L, Han X, Shi X, Xiang Y, Shang H, Zhang L. Stabilized diverse HIV-1 envelope trimers for vaccine design. Emerg Microbes Infect. 2020 Dec;9(1):775-786.
Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L, Wang X. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature. 2020 May;581(7807):215-220.
Wang Q, Zhang L. Broadly neutralizing antibodies and vaccine design against HIV-1 infection. Front Med. 2020 Feb;14(1):30-42.
Gao F, Lin X, He L, Wang R, Wang H, Shi X, Zhang F, Yin C, Zhang L, Zhu J, Yu L. Development of a Potent and Protective Germline-Like Antibody Lineage Against Zika Virus in a Convalescent Human. Front Immunol. 2019 Oct 24;10:2424.
Zhou H, Chen Y, Zhang S, Niu P, Qin K, Jia W, Huang B, Zhang S, Lan J, Zhang L, Tan W, Wang X. Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein. Nat Commun. 2019 Jul 11;10(1):3068.
Zhou P, Wang H, Fang M, Li Y, Wang H, Shi S, Li Z, Wu J, Han X, Shi X, Shang H, Zhou T, Zhang L. Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies. PLoS Pathog. 2019 Jun 13;15(6):e1007819.
Xu J, Jia W, Wang P, Zhang S, Shi X, Wang X, Zhang L. Antibodies and vaccines against Middle East respiratory syndrome coronavirus. Emerg Microbes Infect. 2019;8(1):841-856.
Wang Q, Liu L, Ren W, Gettie A, Wang H, Liang Q, Shi X, Montefiori DC, Zhou T, Zhang L. A Single Substitution in gp41 Modulates the Neutralization Profile of SHIV during In Vivo Adaptation. Cell Rep. 2019 May 28;27(9):2593-2607.e5.
Li G, Jiang Y, Zhang L. HIV upsurge in China's students. Science. 2019 May 24;364(6442):711.
Jia W, Channappanavar R, Zhang C, Li M, Zhou H, Zhang S, Zhou P, Xu J, Shan S, Shi X, Wang X, Zhao J, Zhou D, Perlman S, Zhang L. Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection. Emerg Microbes Infect. 2019;8(1):760-772.
Wang P, Zuo Y, Sun J, Zuo T, Zhang S, Guo S, Shi X, Liang M, Zhou P, Zhang L, Wang X. Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1. J Biol Chem. 2019 Mar 22;294(12):4290-4303.
Wang L, Wang R, Wang L, Ben H, Yu L, Gao F, Shi X, Yin C, Zhang F, Xiang Y, Zhang L. Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody. Cell Rep. 2019 Mar 19;26(12):3360-3368.e5.
Zhang L, Zhong P, Zhai X, Shao Y, Lu S; 149 signatories. Open letter from Chinese HIV professionals on human genome editing. Lancet. 2019 Jan 5;393(10166):26-27.
Wang FS, Zhang L, Douek D, McMichael A, Xu XN, Lewin SR. Strategies for an HIV cure: progress and challenges. Nat Immunol. 2018 Nov;19(11):1155-1158.
Zuo Y, Wang P, Sun J, Guo S, Wang G, Zuo T, Fan S, Zhou P, Liang M, Shi X, Wang X, Zhang L. Complementary recognition of the receptor-binding site of highly pathogenic H5N1 influenza viruses by two human neutralizing antibodies. J Biol Chem. 2018 Oct 19;293(42):16503-16517.
Niu P, Zhang S, Zhou P, Huang B, Deng Y, Qin K, Wang P, Wang W, Wang X, Zhou J, Zhang L, Tan W. Ultrapotent Human Neutralizing Antibody Repertoires Against Middle East Respiratory Syndrome Coronavirus From a Recovered Patient. J Infect Dis. 2018 Sep 8;218(8):1249-1260.
Zhang S, Zhou P, Wang P, Li Y, Jiang L, Jia W, Wang H, Fan A, Wang D, Shi X, Fang X, Hammel M, Wang S, Wang X, Zhang L. Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein. Cell Rep. 2018 Jul 10;24(2):441-452.
Li C, Gao F, Yu L, Wang R, Jiang Y, Shi X, Yin C, Tang X, Zhang F, Xu Z, Zhang L. A Single Injection of Human Neutralizing Antibody Protects against Zika Virus Infection and Microcephaly in Developing Mouse Embryos. Cell Rep. 2018 May 1;23(5):1424-1434.
Wang H, Chen X, Wang D, Yao C, Wang Q, Xie J, Shi X, Xiang Y, Liu W, Zhang L. Epitope-focused immunogens against the CD4-binding site of HIV-1 envelope protein induce neutralizing antibodies against auto- and heterologous viruses. J Biol Chem. 2018 Jan 19;293(3):830-846.
Yu L, Wang R, Gao F, Li M, Liu J, Wang J, Hong W, Zhao L, Wen Y, Yin C, Wang H, Zhang Q, Li Y, Zhou P, Zhang R, Liu Y, Tang X, Guan Y, Qin CF, Chen L, Shi X, Jin X, Cheng G, Zhang F, Zhang L. Delineating antibody recognition against Zika virus during natural infection. JCI Insight. 2017 Jun 15;2(12):e93042.
Shi B, Li J, Shi X, Jia W, Wen Y, Hu X, Zhuang F, Xi J, Zhang L. TALEN-Mediated Knockout of CCR5 Confers Protection Against Infection of Human Immunodeficiency Virus. J Acquir Immune Defic Syndr. 2017 Feb 1;74(2):229-241.
Zhang Q, Gui M, Niu X, He S, Wang R, Feng Y, Kroeker A, Zuo Y, Wang H, Wang Y, Li J, Li C, Shi Y, Shi X, Gao GF, Xiang Y, Qiu X, Chen L, Zhang L. Potent neutralizing monoclonal antibodies against Ebola virus infection. Sci Rep. 2016 May 16;6:25856.
Jin S, Ji Y, Wang Q, Wang H, Shi X, Han X, Zhou T, Shang H, Zhang L. Spatiotemporal hierarchy in antibody recognition against transmitted HIV-1 envelope glycoprotein during natural infection. Retrovirology. 2016 Feb 17;13:12.
Zuo T, Sun J, Wang G, Jiang L, Zuo Y, Li D, Shi X, Liu X, Fan S, Ren H, Hu H, Sun L, Zhou B, Liang M, Zhou P, Wang X, Zhang L. Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection. Nat Commun. 2015 Dec 4;6:8855.
Yu X, Zhang S, Jiang L, Cui Y, Li D, Wang D, Wang N, Fu L, Shi X, Li Z, Zhang L, Wang X. Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27. Sci Rep. 2015 Aug 18;5:13133.
Luo K, Li S, Jiang L, Zuo T, Qing J, Shi X, Liu Y, Wu H, Chen X, Zhang L. Combinatorial library-based profiling of the antibody response against hepatitis C virus in humans. J Gen Virol. 2015 Jan;96(Pt 1):52-63.
Lu L, Wang M, Xia W, Tian L, Xu R, Li C, Wang J, Rong X, Xiong H, Huang K, Huang J, Nakano T, Bennett P, Zhang Y, Zhang L, Fu Y. Migration patterns of hepatitis C virus in China characterized for five major subtypes based on samples from 411 volunteer blood donors from 17 provinces and municipalities. J Virol. 2014 Jul;88(13):7120-9.
Jiang L, Wang N, Zuo T, Shi X, Poon KM, Wu Y, Gao F, Li D, Wang R, Guo J, Fu L, Yuen KY, Zheng BJ, Wang X, Zhang L. Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein. Sci Transl Med. 2014 Apr 30;6(234):234ra59.
Guo D, Shi X, Song D, Zhang L. Persistence of VRC01-resistant HIV-1 during antiretroviral therapy. Sci China Life Sci. 2014 Jan;57(1):88-96.
Wang N, Shi X, Jiang L, Zhang S, Wang D, Tong P, Guo D, Fu L, Cui Y, Liu X, Arledge KC, Chen YH, Zhang L, Wang X. Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4. Cell Res. 2013 Aug;23(8):986-93.
Sun C, Chen Z, Tang X, Zhang Y, Feng L, Du Y, Xiao L, Liu L, Zhu W, Chen L, Zhang L. Mucosal priming with a replicating-vaccinia virus-based vaccine elicits protective immunity to simian immunodeficiency virus challenge in rhesus monkeys. J Virol. 2013 May;87(10):5669-77.
Qian M, Hu H, Zuo T, Wang G, Zhang L, Zhou P. Unraveling of a neutralization mechanism by two human antibodies against conserved epitopes in the globular head of H5 hemagglutinin. J Virol. 2013 Mar;87(6):3571-7.
Guo D, Shi X, Arledge KC, Song D, Jiang L, Fu L, Gong X, Zhang S, Wang X, Zhang L. A single residue within the V5 region of HIV-1 envelope facilitates viral escape from the broadly neutralizing monoclonal antibody VRC01. J Biol Chem. 2012 Dec 14;287(51):43170-9.
Shang H, Xu J, Han X, Spero Li J, Arledge KC, Zhang L. HIV prevention: Bring safe sex to China. Nature. 2012 May 30;485(7400):576-7.
Zuo T, Shi X, Liu Z, Guo L, Zhao Q, Guan T, Pan X, Jia N, Cao W, Zhou B, Goldin M, Zhang L. Comprehensive analysis of pathogen-specific antibody response in vivo based on an antigen library displayed on surface of yeast. J Biol Chem. 2011 Sep 23;286(38):33511-9.
Shang H, Han X, Shi X, Zuo T, Goldin M, Chen D, Han B, Sun W, Wu H, Wang X, Zhang L. Genetic and neutralization sensitivity of diverse HIV-1 env clones from chronically infected patients in China. J Biol Chem. 2011 Apr 22;286(16):14531-41.
Liu Z, Shan M, Li L, Lu L, Meng S, Chen C, He Y, Jiang S, Zhang L. In vitro selection and characterization of HIV-1 variants with increased resistance to sifuvirtide, a novel HIV-1 fusion inhibitor. J Biol Chem. 2011 Feb 4;286(5):3277-87.
Wang H, Zhuang K, Liu L, Tang Z, Tang J, Tien P, Zhang L, Chen Z. Acute infection of Chinese macaques by a CCR5-tropic SHIV carrying a primary HIV-1 subtype B' envelope. J Acquir Immune Defic Syndr. 2010 Mar;53(3):285-91.
Yu W, Fang Q, Zhu W, Wang H, Tien P, Zhang L, Chen Z. One time intranasal vaccination with a modified vaccinia Tiantan strain MVTT(ZCI) protects animals against pathogenic viral challenge. Vaccine. 2010 Feb 25;28(9):2088-96.
Lu L, Jia M, Ma Y, Yang L, Chen Z, Ho DD, Jiang Y, Zhang L. The changing face of HIV in China. Nature. 2008 Oct 2;455(7213):609-11.
Russo A, Chandramouli N, Zhang L, Deng H. Reductive glutaraldehydation of amine groups for identification of protein N-termini. J Proteome Res. 2008 Sep;7(9):4178-82.
He Y, Xiao Y, Song H, Liang Q, Ju D, Chen X, Lu H, Jing W, Jiang S, Zhang L. Design and evaluation of sifuvirtide, a novel HIV-1 fusion inhibitor. J Biol Chem. 2008 Apr 25;283(17):11126-34.
Chen HY, Di Mascio M, Perelson AS, Ho DD, Zhang L. Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques. Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19079-84.
Zhu W, Fang Q, Zhuang K, Wang H, Yu W, Zhou J, Liu L, Tien P, Zhang L, Chen Z. The attenuation of vaccinia Tian Tan strain by the removal of the viral M1L-K2L genes. J Virol Methods. 2007 Sep;144(1-2):17-26.
Zhang Y, Lu L, Ba L, Liu L, Yang L, Jia M, Wang H, Fang Q, Shi Y, Yan W, Chang G, Zhang L, Ho DD, Chen Z. Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China. PLoS Med. 2006 Nov;3(11):e443.
Lin HH, Shih YL, Liu YC, Lee SS, Huang CK, Chen YL, Chin C, Lai CH, Tsai HC, Guo YC, Zhang L. An epidemic of HIV type I CRF07_BC infection among injection drug users in Taiwan. J Acquir Immune Defic Syndr. 2006 Jun;42(2):248-55.
Lin HH, Gaschen BK, Collie M, El-Fishaway M, Chen Z, Korber BT, Beatrice ST, Zhang L. Genetic characterization of diverse HIV-1 strains in an immigrant population living in New York City. J Acquir Immune Defic Syndr. 2006 Apr 1;41(4):399-404.
Zhang L, Zhang F, Yu W, He T, Yu J, Yi CE, Ba L, Li W, Farzan M, Chen Z, Yuen KY, Ho D. Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals. J Med Virol. 2006 Jan;78(1):1-8.
Liu L, Su B, Zhuang K, Tien P, Chen Z, Zhang L. Genetic characterization of full-length HIV type 1 genomes from 3 infected paid blood donors in Henan, China. J Acquir Immune Defic Syndr. 2005 Dec 1;40(4):501-3.
Zhang L, Zhang F, Yu W, He T, Yu J, Yi CE, Ba L, Li W, Farzan M, Chen Z, Yuen KY, Ho D. Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals. J Med Virol. 2006 Jan;78(1):1-8.
Saksena NK, Wang B, Steain M, Yang RG, Zhang LQ. Snapshot of HIV pathogenesis in China. Cell Res. 2005 Nov-Dec;15(11-12):953-61.
Fang Q, Yang L, Zhu W, Liu L, Wang H, Yu W, Xiao G, Tien P, Zhang L, Chen Z. Host range, growth property, and virulence of the smallpox vaccine: vaccinia virus Tian Tan strain. Virology. 2005 May 10;335(2):242-51.
Arron ST, Ribeiro RM, Gettie A, Bohm R, Blanchard J, Yu J, Perelson AS, Ho DD, Zhang L. Impact of thymectomy on the peripheral T cell pool in rhesus macaques before and after infection with simian immunodeficiency virus. Eur J Immunol. 2005 Jan;35(1):46-55.
Zhang L, Chen Z, Cao Y, Yu J, Li G, Yu W, Yin N, Mei S, Li L, Balfe P, He T, Ba L, Zhang F, Lin HH, Yuen MF, Lai CL, Ho DD. Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china. J Virol. 2004 Dec;78(24):13591-9.
Sum SS, Wong DK, Yuen MF, Yuan HJ, Yu J, Lai CL, Ho D, Zhang L. Real-time PCR assay using molecular beacon for quantitation of hepatitis B virus DNA. J Clin Microbiol. 2004 Aug;42(8):3438-40.
Li T, Qiu Z, Zhang L, Han Y, He W, Liu Z, Ma X, Fan H, Lu W, Xie J, Wang H, Deng G, Wang A. Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome. J Infect Dis. 2004 Feb 15;189(4):648-51.
Poles MA, Barsoum S, Yu W, Yu J, Sun P, Daly J, He T, Mehandru S, Talal A, Markowitz M, Hurley A, Ho D, Zhang L. Human immunodeficiency virus type 1 induces persistent changes in mucosal and blood gammadelta T cells despite suppressive therapy. J Virol. 2003 Oct;77(19):10456-67.
Zhuang K, Gui X, Su B, Tien P, Chen Z, Zhang L. High prevalence of HIV infection among women and their children in Henan Province, China. J Acquir Immune Defic Syndr. 2003 Aug 15;33(5):649-50.
Zhang L, Rowe L, He T, Chung C, Yu J, Yu W, Talal A, Markowitz M, Ho DD. Compartmentalization of surface envelope glycoprotein of human immunodeficiency virus type 1 during acute and chronic infection. J Virol. 2002 Sep;76(18):9465-73.
Zhang L, Dailey PJ, Gettie A, Blanchard J, Ho DD. The liver is a major organ for clearing simian immunodeficiency virus in rhesus monkeys. J Virol. 2002 May;76(10):5271-3.
Talal AH, Irwin CE, Dieterich DT, Yee H, Zhang L. Effect of HIV-1 infection on lymphocyte proliferation in gut-associated lymphoid tissue. J Acquir Immune Defic Syndr. 2001 Mar 1;26(3):208-17.
Zhang L, Chung C, Hu BS, He T, Guo Y, Kim AJ, Skulsky E, Jin X, Hurley A, Ramratnam B, Markowitz M, Ho DD. Genetic characterization of rebounding HIV-1 after cessation of highly active antiretroviral therapy. J Clin Invest. 2000 Oct;106(7):839-45.
Ho DD, Zhang L. HIV-1 rebound after anti-retroviral therapy. Nat Med. 2000 Jul;6(7):736-7.
Jin X, Roberts CG, Nixon DF, Safrit JT, Zhang LQ, Huang YX, Bhardwaj N, Jesdale B, DeGroot AS, Koup RA. Identification of subdominant cytotoxic T lymphocyte epitopes encoded by autologous HIV type 1 sequences, using dendritic cell stimulation and computer-driven algorithm. AIDS Res Hum Retroviruses. 2000 Jan 1;16(1):67-76.
Boden D, Hurley A, Zhang L, Cao Y, Guo Y, Jones E, Tsay J, Ip J, Farthing C, Limoli K, Parkin N, Markowitz M. HIV-1 drug resistance in newly infected individuals. JAMA. 1999 Sep 22-29;282(12):1135-41.
Zhang L, Lewin SR, Markowitz M, Lin HH, Skulsky E, Karanicolas R, He Y, Jin X, Tuttleton S, Vesanen M, Spiegel H, Kost R, van Lunzen J, Stellbrink HJ, Wolinsky S, Borkowsky W, Palumbo P, Kostrikis LG, Ho DD. Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy. J Exp Med. 1999 Sep 6;190(5):725-32.
Lewin SR, Vesanen M, Kostrikis L, Hurley A, Duran M, Zhang L, Ho DD, Markowitz M. Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy. J Virol. 1999 Jul;73(7):6099-103.
Zhang L, Ramratnam B, Tenner-Racz K, He Y, Vesanen M, Lewin S, Talal A, Racz P, Perelson AS, Korber BT, Markowitz M, Ho DD. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med. 1999 May 27;340(21):1605-13.
Zhang L, Dailey PJ, He T, Gettie A, Bonhoeffer S, Perelson AS, Ho DD. Rapid clearance of simian immunodeficiency virus particles from plasma of rhesus macaques. J Virol. 1999 Jan;73(1):855-60.
Zhang L, He T, Huang Y, Chen Z, Guo Y, Wu S, Kunstman KJ, Brown RC, Phair JP, Neumann AU, Ho DD, Wolinsky SM. Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1. J Virol. 1998 Nov;72(11):9307-12.
Zhang L, He T, Talal A, Wang G, Frankel SS, Ho DD. In vivo distribution of the human immunodeficiency virus/simian immunodeficiency virus coreceptors: CXCR4, CCR3, and CCR5. J Virol. 1998 Jun;72(6):5035-45.
Binley JM, Jin X, Huang Y, Zhang L, Cao Y, Ho DD, Moore JP. Persistent antibody responses but declining cytotoxic T-lymphocyte responses to multiple human immunodeficiency virus type 1 antigens in a long-term nonprogressing individual with a defective p17 proviral sequence and no detectable viral RNA expression. J Virol. 1998 Apr;72(4):3472-4.
Kostrikis LG, Huang Y, Moore JP, Wolinsky SM, Zhang L, Guo Y, Deutsch L, Phair J, Neumann AU, Ho DD. A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nat Med. 1998 Mar;4(3):350-3.
Huang Y, Zhang L, Ho DD. Characterization of gag and pol sequences from long-term survivors of human immunodeficiency virus type 1 infection. Virology. 1998 Jan 5;240(1):36-49.
Bakshi SS, Zhang L, Ho D, Than S, Pahwa SG. Distribution of CCR5delta32 in human immunodeficiency virus-infected children and its relationship to disease course. Clin Diagn Lab Immunol. 1998 Jan;5(1):38-40.
Zhang L, Huang Y, Yuan H, Chen BK, Ip J, Ho DD. Genotypic and phenotypic characterization of long terminal repeat sequences from long-term survivors of human immunodeficiency virus type 1 infection. J Virol. 1997 Jul;71(7):5608-13.
Chen Z, Luckay A, Sodora DL, Telfer P, Reed P, Gettie A, Kanu JM, Sadek RF, Yee J, Ho DD, Zhang L, Marx PA. Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys. J Virol. 1997 May;71(5):3953-60.
Diaz RS, Zhang L, Busch MP, Mosley JW, Mayer A. Divergence of HIV-1 quasispecies in an epidemiologic cluster. AIDS. 1997 Mar 15;11(4):415-22.
Zhang L, Diaz RS, Ho DD, Mosley JW, Busch MP, Mayer A. Host-specific driving force in human immunodeficiency virus type 1 evolution in vivo. J Virol. 1997 Mar;71(3):2555-61.
Zhang L, Huang Y, Yuan H, Tuttleton S, Ho DD. Genetic characterization of vif, vpr, and vpu sequences from long-term survivors of human immunodeficiency virus type 1 infection. Virology. 1997 Feb 17;228(2):340-9.
Zhang L, Huang Y, Yuan H, Chen BK, Ip J, Ho DD. Identification of a replication-competent pathogenic human immunodeficiency virus type 1 with a duplication in the TCF-1alpha region but lacking NF-kappaB binding sites. J Virol. 1997 Feb;71(2):1651-6.
Huang Y, Paxton WA, Wolinsky SM, Neumann AU, Zhang L, He T, Kang S, Ceradini D, Jin Z, Yazdanbakhsh K, Kunstman K, Erickson D, Dragon E, Landau NR, Phair J, Ho DD, Koup RA. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med. 1996 Nov;2(11):1240-3.
Zhang L, Huang Y, He T, Cao Y, Ho DD. HIV-1 subtype and second-receptor use. Nature. 1996 Oct 31;383(6603):768.
Connor RI, Sheridan KE, Lai C, Zhang L, Ho DD. Characterization of the functional properties of env genes from long-term survivors of human immunodeficiency virus type 1 infection. J Virol. 1996 Aug;70(8):5306-11.
Huang Y, Zhang L, Ho DD. Biological characterization of nef in long-term survivors of human immunodeficiency virus type 1 infection. J Virol. 1995 Dec;69(12):8142-6.
Kostrikis LG, Bagdades E, Cao Y, Zhang L, Dimitriou D, Ho DD. Genetic analysis of human immunodeficiency virus type 1 strains from patients in Cyprus: identification of a new subtype designated subtype I. J Virol. 1995 Oct;69(10):6122-30.
Chen Z, Telfer P, Reed P, Zhang L, Getti A, Ho DD, Marx PA. Isolation and characterization of the first simian immunodeficiency virus from a feral sooty mangabey (Cercocebus atys) in West Africa. J Med Primatol. 1995 May;24(3):108-15.
Holmes EC, Zhang LQ, Robertson P, Cleland A, Harvey E, Simmonds P, Leigh Brown AJ. The molecular epidemiology of human immunodeficiency virus type 1 in Edinburgh. J Infect Dis. 1995 Jan;171(1):45-53.
Cao Y, Qin L, Zhang L, Safrit J, Ho DD. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med. 1995 Jan 26;332(4):201-8.
Huang Y, Zhang L, Ho DD. Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection. J Virol. 1995 Jan;69(1):93-100.
Holmes EC, Zhang LQ, Simmonds P, Rogers AS, Brown AJ. Molecular investigation of human immunodeficiency virus (HIV) infection in a patient of an HIV-infected surgeon. J Infect Dis. 1993 Jun;167(6):1411-4.
Zhang LQ, MacKenzie P, Cleland A, Holmes EC, Brown AJ, Simmonds P. Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection. J Virol. 1993 Jun;67(6):3345-56.
Rogers AS, Froggatt JW 3rd, Townsend T, Gordon T, Brown AJ, Holmes EC, Zhang LQ, Moses H 3rd. Investigation of potential HIV transmission to the patients of an HIV-infected surgeon. JAMA. 1993 Apr 14;269(14):1795-801.
Holmes EC, Zhang LQ, Simmonds P, Ludlam CA, Brown AJ. Convergent and divergent sequence evolution in the surface envelope glycoprotein of human immunodeficiency virus type 1 within a single infected patient. Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4835-9.
Watson HG, Ludlam CA, Rebus S, Zhang LQ, Peutherer JF, Simmonds P. Use of several second generation serological assays to determine the true prevalence of hepatitis C virus infection in haemophiliacs treated with non-virus inactivated factor VIII and IX concentrates. Br J Haematol. 1992 Apr;80(4):514-8.
Simmonds P, Zhang LQ, McOmish F, Balfe P, Ludlam CA, Brown AJ. Discontinuous sequence change of human immunodeficiency virus (HIV) type 1 env sequences in plasma viral and lymphocyte-associated proviral populations in vivo: implications for models of HIV pathogenesis. J Virol. 1991 Nov;65(11):6266-76.
Zhang LQ, Simmonds P, Ludlam CA, Brown AJ. Detection, quantification and sequencing of HIV-1 from the plasma of seropositive individuals and from factor VIII concentrates. AIDS. 1991 Jun;5(6):675-81.
Simmonds P, Zhang LQ, Watson HG, Rebus S, Ferguson ED, Balfe P, Leadbetter GH, Yap PL, Peutherer JF, Ludlam CA. Hepatitis C quantification and sequencing in blood products, haemophiliacs, and drug users. Lancet. 1990 Dec 15;336(8729):1469-72.
Complete list of publications: https://scholar.google.com/citations?hl=en&user=0KXZijUAAAAJ
