教育背景

2007-2011 厦门大学生命科学学院 学士

2011-2016 清华大学生命科学学院 博士

工作经历

2017-2021 哈佛大学医学院和波士顿儿童医院 博士后

2021-2023 哈佛大学医学院和波士顿儿童医院 讲师

2023- 2024 清华大学医学院 助理教授

2024-至今 清华大学基础基础医学院 助理教授

研究领域

新型疫苗和治疗性抗体的研究与开发；B细胞受体多样化的机制研究。目前的研究兴趣包括通过人源化小鼠模型探究病毒感染过程中引发的宿主免疫应答，研究和重塑高突变RNA病毒与宿主免疫系统的共进化过程，开发新型疫苗和广谱中和抗体。同时，进一步研究B细胞受体在发育过程中多样化的产生机制以及可能由非编码RNA介导的调控作用。

荣誉奖励

2021年 第九届Norman L. Letvin青年学者奖

2016年 吴瑞奖学金

代表性论文

1.S. Luo*†, J. Zhang†, A. J. B. Kreutzberger†, A. Eaton, R. J. Edwards, C. Jing, H. Q. Dai, G. D. Sempowski, K. Cronin, R. Parks, A. Y. Ye, K. Mansouri, M. Barr, N. Pishesha, A. C. Williams, L. Vieira Francisco, A. Saminathan, H. Peng, H. Batra, L. Bellusci, S. Khurana, S. M. Alam, D. C. Montefiori, K. O. Saunders, M. Tian, H. Ploegh, T. Kirchhausen*, B. Chen*, B. F. Haynes*, F. W. Alt*, An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion. Sci Immunol 7, eadd5446 (2022). (†co-first author) (*co-corresponding author)

2.S. Luo†, C. Jing†, A. Y. Ye†, S. Kratochvil, C. A. Cottrell, J. Koo, A. C. Williams, L. V. Francisco, H. Batra, E. Lamperti, O. Kalyuzhniy, Y. Zhang, A. Barbieri, J. P. Manis, B. F. Haynes, W. R. Schief, F. D. Batista, M. Tian, F. W. Alt, Humanized V(D)J-rearranging and TdT-expressing Mouse Vaccine Models with Physiological HIV-1 Broadly Neutralizing Antibody Precursors. Proc Natl Acad Sci, U S A 120, e2217883120 (2023) (†co-first author)

3.C. Cottrell†, X. Hu†, J. Lee† , P. Skog, S. Luo, C. Flynn, K. McKenney, J. Hurtado, O. Kalyuzhniy, A. Liguori, J. Willis, E. Landais, S. Raemisch, X. Chen, S. Baboo, S. Himansu, J. Diedrich, H. Duan, C. Cheng, T. Schiffner, D. Bader, D. Kulp, R. Tingle, E. Georgeson, S. Eskandarzadeh, N. Alavi, D. Lu, T. Sincomb, M. Kubitz, T. Mullen, J. Yates III, J. Paulson, J. Mascola, F. Alt, B. Briney, D. Sok, and W. Schief, Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in a humanized mouse model. Science Translational Medicine (2024)

4.X. Han†, S. Luo†, G. Peng, J. Y. Lu, G. Cui, L. Liu, P. Yan, Y. Yin, W. Liu, R. Wang, J. Zhang, S. Ai, Z. Chang, J. Na, A. He, N. Jing, X. Shen, Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development. J Mol Cell Biol 10, 175-178 (2018). (†co-first author)

5.P. Yan, S. Luo, J. Y. Lu, X. Shen, Cis- and trans-acting lncRNAs in pluripotency and reprogramming. Curr Opin Genet Dev 46, 170-178 (2017).

6.S. Luo, J. Y. Lu, L. Liu, Y. Yin, C. Chen, X. Han, B. Wu, R. Xu, W. Liu, P. Yan, W. Shao, Z. Lu, H. Li, J. Na, F. Tang, J. Wang, Y. E. Zhang, X. Shen, Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells. Cell Stem Cell 18, 637-652 (2016).