教育背景

1992-1997 北京大学医学部 医学学士

1997-2002 美国弗吉尼亚大学 细胞生物学博士

工作经历

2002-2005 英国剑桥大学Wellcome Trust Gurdon Institute博士后

2005-2010 英国医学研究学会MRC Career Development Fellow

2010-2019 清华大学医学院 副教授 

2019-2024 清华大学医学院 长聘副教授 

2024-至今 清华大学基础医学院 长聘副教授

研究领域

主要研究方向为干细胞与再生医学，人类多能干细胞向心血管细胞、造血干祖细胞和免疫细胞分化的调控机制，应用这些细胞制作类器官模型, 研究人类器官发育和疾病机理，促进细胞治疗等临床转化应用。 另一研究方向为哺乳动物早期胚胎发育调控, 影响人类胚胎早期发育的遗传突变及作用原理。作为项目负责人多次承担科技部重大科学研究计划干细胞专项、国家自然科学基金项目。在Nature、Science等国际权威刊物发表干细胞、胚胎发育、类器官方面论文70余篇，他引4000余次。获得若干项国家专利。为多个国际学术刊物的审稿人，国际干细胞研究学会会员，中国动物学会生殖生物学分会委员，中国细胞生物学学会，生理学会会员。

荣誉奖励

2019 教育部高等学校科学研究优秀成果奖(科学技术)一等奖

2018 清华大学先进工作者

2010 英国Wellcome Trust Value in People Award

代表性论文

1.Mengda Li, Peiliang Wang, Si Tong Huo, Hui Qiu, Chendi Li, Siyong Lin, Libin Guo, Yicong Ji, Yonglin Zhu, Jinyang Liu, Jianying Guo, Jie Na* and Yuntao Hu*. Human pluripotent stem cells derived endothelial cells repair choroidal ischemia. Advanced Science. 2023, 2302940

2.Chen X, Wang P, Qiu H, Zhu Y, Zhang X, Zhang Y, Duan F, Ding S, Guo J, Huang Y, Na J*. Integrative epigenomic and transcriptomic analysis reveals the requirement of JUNB for hematopoietic fate induction. Nature Communications, 2022, 13:3131, doi:10.1038/s41467-022-30789-4

3.Huang R, Liu J, Chen X, Zhi Y, Ding S, Ming J, Li Y, Wang Y, and Na J. A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions. Protein Cell. 2022. 10.1093/procel/pwac019/6645080.

4.Chen X, Wang P, Qiu H, Zhu Y, Zhang X, Zhang Y, Duan F, Ding S, Guo J, Huang Y, Na J. Integrative epigenomic and transcriptomic analysis reveals the requirement of JUNB for hematopoietic fate induction. Nature Communications, 2022, 13:3131, doi:10.1038/s41467-022-30789-4

5.Guo J, Wang P, Sozen B, Qiu H, Zhu Y, Zhang X, Ming J, Zernicka-Goetz M, Na J. Machine learning-assisted high-content analysis of pluripotent stem cell-derived embryos in vitro. Stem Cell Reports. 2021,16(5):1331-1346. doi: 10.1016/j.stemcr.2021.03.018.

6.Chen, B., Guo, J., Wang, T., Lee, Q., Ming, J., Ding, F., Li, H., Zhang, Z., Li, L., Cao, Y., and Na, J.* Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes. Protein Cell. 2021, 10.1007/s13238-021-00844-9.

7.Zhang F, Zhu Y, Chen J, Kuang W, Huang R, Duan F, Li Y, Wang L, Qiu H, Chen X, Ming J, Liu P, Du Y, Chang SC, Chen L, Na J. Efficient endothelial and smooth muscle cell differentiation from human pluripotent stem cells through a simplified insulin-free culture system. Biomaterials. 2021 Apr;271:120713. doi: 10.1016/j.biomaterials.2021.120713.

8.Wang L, Zhang F, Duan F, Huang R, Chen X, Ming J, Na J. Homozygous MESP1 knock-in reporter hESCs facilitated cardiovascular cell differentiation and myocardial infarction repair. Theranostics. 2020;10(15):6898-6914. doi: 10.7150/thno.42347.

9.Zhang J, Hirst A.J, Duan F, Qiu H, Huang R, Ji Y, Bai L, Zhang F, Robinson D, Jones M, … Na J. Anti-apoptotic Mutations Desensitize Human Pluripotent Stem Cells to Mitotic Stress and Enable Aneuploid Cell Survival. Stem Cell Reports. 2019, 12, 557-571. 10.1016/j.stemcr.2019.01.013.

10.Duan F, Huang R, Zhang F, Zhu Y, Wang L, Chen X, Bai L, Guo W, Chang SC, Hu X, and Na J. Biphasic modulation of insulin signaling enables highly efficient hematopoietic differentiation from human pluripotent stem cells. Stem Cell Research & Therapy 2018. 9, 205. 10.1186/s13287-018-0934-x.

11.Wu J, Xu J, Liu B, Yao G, Wang P, Lin Z, Huang B, Wang X, Li T, Shi S, …Na J*, Xie W* and Sun Y*. Chromatin analysis in human early development reveals epigenetic transition during ZGA. Nature 2018. 557:256-260. 10.1038/s41586-018-0080-8.

12.Li W, Wang P, Zhang B, Zhang J, Ming J, Xie W and Na J*. Differential regulation of H3S10 phosphorylation, mitosis progression and cell fate by Aurora Kinase B and C in mouse preimplantation embryos. Protein Cell. 2017, 9:662-674, doi:10.1007/s13238-017-0407-5.

13.Guo J, Ma D, Huang R, Ming J, Ye M, Kee K, Xie Z. and Na J* An inducible CRISPR-ON system for controllable gene activation in human pluripotent stem cells. Protein Cell 2017. 8, 379-393. 10.1007/s13238-016-0360-8.

14.Zhang F, Wang L, Li Y, Liu W, Duan F, Huang R, Chen X, Chang SC, Du Y, and Na J.* Optimizing mesoderm progenitor selection and three-dimensional microniche culture allows highly efficient endothelial differentiation and ischemic tissue repair from human pluripotent stem cells. Stem Cell Research & Therapy 2017. 8. 10.1186/s13287-016-0455-4.

15.Zhang B, Zheng H, Huang B, Li W, Xiang Y, Peng X, Ming J, Wu X, Zhang Y, Xu Q, Liu W, Kou X, Zhao Y, He W, Li C, Chen B, Li Y, Wang Q, Ma J, Yin Q, Kee K, Meng A, Gao S, Xu F, Na J* and Xie W*. 2016. Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature, 537:553-557. doi: 10.1038/nature19361