教育背景

1998-2002 清华大学数理基科班 学士

2002-2007 清华大学医学院 博士

工作经历

2007-2010 清华大学医学院 讲师/助理研究员

2010-2014 清华大学医学院 副教授/副研究员

2014-2024 清华大学医学院 教授/研究员 

2024-至今 清华大学基础医学院 教授

研究领域

娄智勇博士主要研究高致病性病毒感染和复制、与宿主相互作用过程中的分子机制，以及对病毒生命过程进行调控的手段。在冠状病毒、发热伴血小板减少综合征病毒、克里米亚－刚果出血热病毒、汉塔病毒、布尼维尔病毒等布尼亚病毒转录复制机制、丙型肝炎病毒和手足口病病毒感染机制、流感病毒聚合酶复合体工作机制、新型激素受体识别机制、以及高效抗病毒抑制剂等研究中，取得了具有影响力的创新性成果

科学贡献

先后发现或阐明布尼亚病毒、冠状病毒等RNA病毒生命周期中转录复制的分子机制，深入揭示了新型冠状病毒RNA合成、延伸、加帽和错配校正等转录复制过程的详细分子机制，发现新的药物靶点与抑制剂。迄今在Cell、Nature、Science、Nature Microbiology、Nature Structure Molecular Biology、Nature Communications、PNAS、PLoS Pathogens和J. Virology等期刊上发表研究论文150余篇，并受邀在Annual Review Biochemistry、Trends in Microbiology、Trends in Pharmacological Sciences和Current Opinion in Virology上发表特邀综述，论文总计被引15300余次（google scholar），H-index 57。

荣誉奖励

2025 中华医学科技奖青年科学技术奖

2023 何梁何利基金科学与技术创新奖

2021 中国科学十大进展

2021 中国生命科学领域十大进展

2020 谈家桢生命科学创新奖

2018 中国晶体学会青年科技奖

2016 教育部高等学校十大科技进展

2016 中国生命科学领域十大科技进展

2014 “树兰医学奖”青年奖

2011 北京市科学技术奖一等奖（第二完成人）

代表性论文

(1)A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors. Yan L, Huang Y, Ge J, Liu Z, Lu P, Huang B, Gao S, Wang J, Tan L, Ye S,Yu F, Lan W, Xu S, Zhou F, Shi L, Guddat L. W, Gao Y*, Rao Z*, Lou Z*, Cell 2022 Nov 10; 185(23): 4347-4360.e17. doi: 10.1016/j.cell.2022.09.037.

(2)Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading. Yan L, Yang Y, Li M, Zhang Y, Zheng L, Ge J, Huang Y, Liu Z, Wang T, Gao S, Zhang R, Huang Y, Guddat LW, Gao Y*, Rao Z*, Lou Z*. Cell. 2021 May 24; 184(13): 3474-3485

(3)Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. Yan L, Ge J, Zheng L, Zhang Y, Gao Y, Wang T, Huang Y, Yang Y, Gao S, Li M, Liu Z, Wang H, Li Y, Chen Y, Guddat LW, Wang Q, Rao Z*, Lou Z*. Cell. 2020 Nov 14:S0092-8674(20)31533-6. doi: 10.1016/j.cell.2020.11.016.

(4)Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Gao Y, Yan L, Huang Y, Liu F, Zhao Y, Cao L, Wang T, Sun Q, Ming Z, Zhang L, Ge J, Zheng L, Zhang Y, Wang H, Zhu Y, Zhu C, Hu T, Hua T, Zhang B, Yang X, Li J, Yang H, Liu Z, Xu W, Guddat LW, Wang Q*, Lou Z*, Rao Z*. Science. 2020 Apr 10. pii: eabb7498. doi: 10.1126/science.abb7498.

(5)DWARF14 is a non-canonical hormone receptor for strigolactone. Yao R, Ming Z, Yan L, Li S, Wang F, Ma S, Yu C, Yang M, Chen L, Chen L, Li Y, Yan C, Miao D, Sun Z, Yan J, Sun Y, Wang L, Chu J, Fan S, He W, Deng H, Nan F, Li J, Rao Z*, Lou Z*, Xie D*. Nature. 2016 Aug 1. doi: 10.1038/nature19073.

(6)The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function. Lou Z*, Rao Z*, Annual Review Biochemistry. 2022 Jun 21;91:381-401. doi: 10.1146/ annurev-biochem-052521-115653.

(7)Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation. Wang P, Liu L, Liu A, Yan L, He Y, Shen S, Hu M, Guo Y, Liu H, Liu C, Lu Y, Wang P, Deng F*, Rao Z*, Lou Z*. Nature Microbiology. 2020 Apr 24.

(8)Architecture of a SARS-CoV-2 mini replication and transcription complex. Yan L, Zhang Y, Ge J, Zheng L, Gao Y, Wang T, Jia Z, Wang H, Huang Y, Li M, Wang Q, Rao Z*, Lou Z*. Nature Commun. 2020 Nov 18;11(1):5874. doi: 10.1038/s41467-020-19770-1.

(9)Divergent engagements between adeno-associated viruses with their cellular receptor AAVR. Zhang R, Xu G, Cao L, Sun Z, He Y, Cui M, Sun Y, Li S, Li H, Qin L, Hu M, Yuan Z, Rao Z, Ding W, Rao Z, Lou Z*. Nature Commun. 2019 Aug 21;10(1):3760. doi: 10.1038/s41467-019-11668-x.

(10)Adeno-associated virus 2 bound to its cellular receptor AAVR. Zhang R, Cao L, Cui M, Sun Z, Hu M, Zhang R, Stuart W, Zhao X, Yang Z, Li X, Sun Y, Li S, Ding W*, Lou Z*, Rao Z. Nature Microbiol. 2019 Apr;4(4):675-682. doi: 10.1038/s41564-018-0356-7. Epub 2019 Feb 11.

(11)Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2. Wang H, Zhang Y, Huang B, Deng W, Quan Y, Wang W, Xu W, Zhao Y, Li N, Zhang J, Liang H, Bao L, Xu Y, Ding L, Zhou W, Gao H, Liu J, Niu P, Zhao L, Zhen W, Fu H, Yu S, Zhang Z, Xu G, Li G, Lou Z^$, Xu M, Qin C, Wu G, Gao GF^*, Tan W^*, Yang X^*. Cell. June 06, 2020 doi://doi.org/10.1016/j.cell.2020.06.008 (Leading Contact)

(12)Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation. Li B., Wang Q., Pan X., Fernández de Castro, I., Sun Y., Guo Y., Tao X., Risco C., Sui S.F. and Lou Z.* Proc Natl Acad Sci USA 2013 May 28;110(22):9048-53

(13)Crimean-Congo hemorrhagic fever virus nucleoprotein reveals an endonuclease activity in the Bunyaviruses. Guo Y., Wang W., Ji W., Deng M., Sun Y., Zhou H., Yang C., Deng F., Wang H., Hu Z.*, Lou Z.* and Rao Z*. Proc Natl Acad Sci USA 2012 Mar 27;109(13):5046-51.

(14)Cyclophilin A associates with enterovirus-71 virus capsid and plays an essential role in viral infection as an uncoating regulator. Qing J, Wang Y, Sun Y, Huang J, Yan W, Wang J, Su D, Ni C, Li J, Rao Z, Liu L*, Lou Z*. PLoS Pathog. 2014 Oct 2;10(10):e1004422.

(15)Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion. Yan L, Qi Y, Huang X, Yu C, Lan L, Guo X, Rao Z, Hu J*, Lou Z*. Nat Struct Mol Biol. 2018 Mar;25(3):233-243. doi: 10.1038/s41594-018-0034-8. Epub 2018 Feb 26.

(16)Structures of human mitofusin 1 provide insight into mitochondrial tethering Qi Y., Yan L., Yu C., Guo X., Zhou X., Hu X., Huang X., Rao Z., Lou Z.*, Hu J*. J Cell Biol. 2016 Nov 14

(17)Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypic ER fusion. Yan L, Sun S, Wang W, Shi J, Hu X, Wang S, Su D, Rao Z, Hu J*, Lou Z.* J Cell Biol. 2015 Sep 14;210(6):961-72.

(18)Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Yuan P.^$, Bartlam M.^$, Lou Z.^$, Chen S., Zhou J., He X., Lv Z., Ge R., Li X., Deng T., Fodor E., Rao Z. and Liu Y. Nature. 2009 Apr 16; 458(7240):909-13. (共同第一作者)

(19)Formation and working mechanism of the picornavirus VPg uridylylation complex. Sun Y, Guo Y, Lou Z*. Curr Opin Virol. 2014 Dec;9:24-30. doi: 10.1016/j.coviro.2014.09.003. (invited review)

(20)Current progress in antiviral strategies. Lou Z*, Sun Y, Rao Z*. Trends Pharmacol Sci. 2014 Feb;35(2):86-102. (invited review)

Structural perspective on the formation of ribonucleoprotein complex in negative-sense single-stranded RNA viruses. Zhou H, Sun Y, Guo Y, Lou Z*. Trends Microbiol. 2013 Sep;21(9):475-84. (invited review)

Complete list of publications: https://scholar.google.cz/citations?hl=zh-CN&user=4X8K29EAAAAJ