教育背景

2010-2016 MD Anderson Cancer Center 肿瘤生物学 博士

2005-2010 南方医科大学 医学学士

工作经历

2019-至今 清华大学基础医学院 教研系列副教授

2016-2019 哈佛医学院 博士后

研究领域

肿瘤对治疗耐药，尤其是对免疫治疗不响应是亟待解决的临床难题。潘登博士长期致力于肿瘤免疫逃逸机制与原创肿瘤治疗靶点发现研究。研究主要围绕“靶点筛选-机制解析-药物转化”思路展开，利用团队自主开发的多种基于肿瘤与免疫细胞互作的遗传学筛选平台，结合多组学技术、单细胞测序、表观遗传分析等技术深入解析肿瘤对免疫治疗耐受的分子机制，筛选并鉴定可逆转相应免疫逃逸机制的分子靶点，以期开发新型的免疫治疗药物，提升肿瘤对免疫治疗的响应率。

科学贡献

围绕上述研究方向，潘登博士与合作者通过研发基于肿瘤免疫细胞互作的遗传学筛选体系，发现SWI/SNF以及SERPINB9分子在肿瘤与T细胞互作中的核心作用（Science, 2018；Nature Medicine, 2018 ）；揭示Glut1/Gpi1等糖代谢关键分子介导的肿瘤代谢重编程与免疫逃逸的分子机制（Cell Metabolism, 2023）；解析TNF等细胞因子网络调控免疫细胞抗肿瘤效应及跨细胞通讯规律（Cancer Discovery, 2023，; Immunity, 2025）。此外，团队还建立了一套肿瘤免疫治疗靶点从发现推向转化的机制。例如，团队发现针对肿瘤免疫逃逸关键节点ICAM-1/LFA-1通路，并研发了双特异抗体药物LFA-1接合器，其在临床前模型中展现了优越的肿瘤治疗效果（Cell Reports Medicine, 2025），为推动创新性肿瘤免疫治疗打下基础。

荣誉奖励

2019 国家青年人才计划

2019 拜耳研究员

代表性论文：

PI时期论文

Lu Y, Luo C, Huang L, Wu G, Zhong L, Chu J, Wang F^#, Zeng Z^# and Pan D^#. Functional genetic screens reveal key pathways instructing the molecular phenotypes of tumor-associated macrophages. Cancer Immunology Research, In Press (# denotes corresponding authors)

Tang K, Wu L^#, Hu Y, Xue T, Jin Y, Zhou X, Luo C, Zhao Y, Tong L, Dai J, Feng D, Zeng Z^# and Pan D^#. Perturbation of Calreticulin potentiates CD8+ T cell-mediated anti-tumor immunity. Journal of Experimental Medicine, 2025 Oct 6;222(10):e20242360. doi: 10.1084/jem.20242360. Epub 2025 Aug 20. (# denotes corresponding authors)

Zhou X, Xu T, Li C, He Y, Hu Y, Gong H, Li J, Jiang H, Wen L, Fu Y, Zeng Z^#, Pan D^#. Potentiating anti-tumor immunity by re-engaging immune synapse molecules. Cell Reports Medicine, Feb 14:101975. doi: 10.1016/j.xcrm.2025.101975. (# denotes corresponding authors)

Luo C, Zhang R, Guo R, Wu L, Xue T, He Y, Jin Y, Zhao Y, Zhang Z, Zhang P, Ye S, Li X, Li D, Zhang W, Wang C, Lai L, Pan-Hammarström Q, Wucherpfennig KW, Gao Z^#, Pan D^#, Zeng Z^# Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells. Immunity, 2025 Mar 11;58(3):745-765.e9. doi: 10.1016/j.immuni.2025.02.007. (# denotes corresponding authors)

X. Wang, T. Zhang, B. Zheng, Y. Lu, Y. Liang, G. Xu, L. Zhao, Y. Tao, Q. Song, H. You, H. Hu, X. Li, K. Sun, T. Li, Z. Zhang, J. Wang, X. Lan, D. Pan, Y.-X. Fu, B. Yue, H. Zheng, Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth.Nature Cell Biology 26, 1597–1612 (2024).

Wu L, Jin Y, Zhao X, Tang K, Zhao Y, Tong L, Yu X, Xiong K, Luo C, Zhu J, Wang F^#, Zeng Z^#, Pan D^#. Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNFa. Cell Metabolism, 2023 Sep 5;35(9):1580-1596.e9. doi: 10.1016/j.cmet.2023.07.001. (# denotes corresponding authors)

Meng J, Jiang YZ, Zhao S, Tao Y, Zhang T, Wang X, Zhang Y, Sun K, Yuan M, Chen J, Wei Y, Lan X, Chen M, David CJ, Chang Z, Guo X, Pan D, Chen M, Shao ZM, Kang Y, Zheng H. Tumor-derived Jagged1 promotes cancer progression through immune evasion. Cell Reports 2022 Mar 8; 38(10):110492

博士后和学生时期论文

Ito Y*, Pan D*, Zhang W, Zhang X, Juan TY, Pyrdol JW, Kyrysyuk O, Doench JG, Liu XS, Wucherpfennig KW. Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-Secreted Cytokines. Cancer Discovery 2023 May 4;13(5):1186-1209. doi: 10.1158/2159-8290.CD-22-1125. (* Denotes equal contribution)

Shi S, Gu S, Han T, Zhang W, Huang L, Li Z, Pan D, Fu J, Ge J, Brown M, Zhang P, Jiang P, Wucherpfennig KW, Liu XS. Inhibition of MAN2A1 Enhances the Immune Response to Anti-PD-L1 in Human Tumors. Clinical Cancer Research 2020 Nov 15;26(22):5990-6002.

Ferrari de Andrade L, Kumar S, Luoma AM, Ito Y, Alves da Silva PH, Pan D, Pyrdol JW, Yoon CH, Wucherpfennig KW. Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells Cancer Immunology Research. 2020 Jun;8(6):769-780.

De Andrade LF, Lu Y, Luoma A, Ito Y, Pan D, Pyrdol JW, Yoon CH, Yuan GC, Wucherpfennig KW. Discovery of specialized NK cell populations infiltrating human melanoma metastasis. JCI Insight. 2019 Dec 5;4(23):e133103.

Pan D*, Kobayashi A*, Jiang P*, Andrade LF, Tay RE, Luoma A, Tsoucas D, Qiu X, Lim K, Rao P, Long HW, Yuan G, Doench J, Brown M, Liu XL, and Wucherpfennig KW. A Major Chromatin Regulator Determines Resistance of Tumor cells to T cell Mediated Killing. Science, 2018 Jan 4; pii:eaao1710 doi: 10.1126/science.aao1710. (* Denotes equal contribution)

(Highlighted paper for postdoctoral work)

Jiang P*, Gu S*, Pan D*, Fu J, Li Z, Bu X, Li B, Liu JS, Freeman G, Brown M, Wucherpfennig KW and Liu XL. Signatures of T-cell dysfunction and exclusion predict cancer immunotherapy response. Nature Medicine, 2018 Oct;24(10):1550-1558. (* Denotes equal contribution)

(Highlighted paper for postdoctoral work)

Andrade LF, Tay RE, Pan D, Luoma A, Ito Y, Badrinath S, Tsoucas D, Franz B, May KF, Kobold S, Pyrdol JW, Yoon C, Yuan GC, Hodi S, Dranoff G and Wucherpfennig KW. Antibody-Mediated Blockade of MICA/B Shedding Promotes NK Cell-Driven Tumor Immunity. Science 2018, Mar 30; Vol 359, Issue 6383, pp. 1537-1542) DOI: 10.1126/science.aao0505

Zhang S, Pan D, Jia XM, Lin X and Zhao X. The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-kB activation and cell survival. Protein Cell. 2017 Nov; 8(11):856-860.

Wang A, Ding X, Demarque M, Liu X, Pan D, Xin H, Zhong B, Wang X, Dejean A, Jin W and Dong C. Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes. Journal of Immunology 2017 May 1; 198(9): 3461-3470.

Pan D, Jiang C, Ma Z, Blonska M, You MJ and Lin X. The role of MALT1 in EGFR induced NF-kappaB activation and EGFR associated lung cancer progression. Oncogene. 2016 Feb 18; 35(7):919-28.

Pan D*, Zhu Y*, Zhou Z, Wang T, You H, Jiang C and Lin X. CARMA3-BCL10-MALT1 -mediated NF-kB activation contributes to HRE2-assocaited tumor malignancy in breast cancer. Molecular Cancer Research 2016 Jan ;14(1):93-102. (* denotes equal contribution)

Wang T, Pan D, Zhou Z, You Y, Jiang C, Zhao X and Lin X. Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLOS Pathogens; 2016 Jun 9;12(6): e1005662.

Pan D and Lin X. EGFR-activated NF-kappaB Signaling and Its Role in EGFR-associated

Tumors. Cancer Journal. 2013 Nov-Dec;19(6):461-7.

Wang A, Pan D, Lee Y, Gustavo M, Feng XF, and Dong C. Cutting Edge: Smad2 and Smad4 regulate TGFbeta-mediated Il9 gene expression via EZH2 displacement. Journal of Immunology 2013 Nov 15; 191(10):4908-12.

Pan D, Hu J, Ma Q, Pan W and Li M. Diversity and prevalence of the C-terminal region of Plasmodium falciparum Merozoite Surface Protein 1 in China. Acta Trop. 2010 Dec; 116(3): 200-5.

联系方式：

E-mail: dpan[AT]tsinghua.edu.cn

地址：北京市海淀区清华大学医学科学楼B115

实验室网站：https://www.pan-lab-at-tsinghua.com