教育背景
2009-2013 山东大学生命科学学院 学士
2013-2018 清华大学生命科学学院 博士
工作经历
2019-2023 UNC Chapel Hill 博士后
2023-2024 杜克大学 博士后
2025-至今 清华大学基础医学院 助理教授
研究领域
赵帅博士的研究领域为肿瘤表观遗传学和肿瘤免疫，主要关注于基因组非编码元件，包括以内源性逆转录病毒（ERV）为代表的反转座子元件的分子调控机理及其对于肿瘤免疫的影响。主要研究方向包括新型ERV调控元件的发现、ERV元件调控蛋白在癌症的功能、肿瘤中转座元件的空间生物学解析等。
科学贡献
赵帅博士的研究工作围绕染色质修饰调控蛋白展开，开发和改进了多种筛选及鉴定技术，发现了多个新型染色质修饰识别蛋白，并深入研究了其在分子、细胞及模式动物水平的调控机理。主要科学贡献包括：（1）异染色质ERV区域特异的H3K9me3修饰识别蛋白TNRC18的发现及其对肿瘤免疫的调控功能（Nature 2023）。（2）新型组蛋白修饰及DNA修饰识别蛋白的鉴定及机理研究，如DNA N6-mA修饰（Nature 2020）、组蛋白五羟色胺化修饰（PNAS 2021）及组蛋白组胺化修饰（Nature 2025）。（3）染色质修饰识别蛋白鉴定技术的开发及基于高通量筛选的新元件发现（PNAS 2017; Cell Reports 2018; Cell Research 2019）。
代表性论文
(*Co-first author; #Co-corresponding author)
1. Zhao S*, Lu J*, Pan B, Fan H, Byrum S, Xu C, Kim A, Guo Y, Kanchi K, Gong W, Sun T, Storey A, Burkholder N, Mackintosh S, Kuhlers P, Edmondson R, Strahl B, Diao Y, Tackett A, Raab J, Cai L, Song J#, Wang G# (2023) TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons. Nature 623: 633–642
2. Li Z*, Zhao S*, Nelakanti R*, Lin K*, Wu T*, Alderman III M, Guo C, Wang P, Zhang M, Min W, Jiang Z, Wang Y, Li H#, Xiao A# (2020) N6-methyladenine in DNA antagonizes SATB1 in early development. Nature 583: 625-630
3. Zheng Q*, Weekley B*, Vinson D*, Zhao S*, Bastle R*, Thompson R, Stransky S, Ramakrishnan A, Cunningham A, Dutta S, Chan J, Salvo GD, Chen M, Zhang N, Wu J, Fulton S, Kong L, Wang H, Zhang B, Vostal L, Upad A, Dierdorff L, Shen L, Molina H, Sidoli S, Muir T, Li H#, David Y#, Maze I# (2025) Histone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity. Nature 637: 974-982
4. Zhao S, Allis CD, Wang G (2021) The language of chromatin modification in human cancers. Nat. Rev. Cancer 21: 413-430 (Cover Story)
5. Zhao S*, Chuh K*, Zhang B*, Xu N, Xue Y, Liu X, Farrelly F, Thompson R, Roeder R, Maze I#, Muir T#, Li H# (2021) Histone H3Q5 serotonylation stabilizes H3K4me3 and potentiates its readout by TAF3. PNAS 118 (6) e2016742118
6. Zhao S*, Cheng L*, Gao Y*, Zhang B*, Zheng X, Wang L, Li P#, Sun Q#, and Li H# (2019) Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation. Cell Research 29 (1): 54-66
7. Zhao S*, Zhang B*, Yang M, Zhu J, and Li H (2018) Systematic profiling of histone readers in Arabidopsis thaliana. Cell Reports 22: 1090-1102
8. Zhao S*, Yang M*, Zhou W, Zhang B, Cheng Z, Huang J. Zhang M, Wang Z, Wang R, Chen Z, Zhu J#, and Li H# (2017) Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology. PNAS 114: E7245-E7254
9. Zhao S, Yue Y, Li Y, Li H (2019) Identification and characterization of “readers” for novel histone modifications. Curr Opin Chem Biol 51: 57-65
10. Zhao S*, Zhang X*, and Li H (2018) Beyond histone acetylation – writing and erasing histone acylations. Curr Opin Struc Biol 53:169–177
11. Xu C, Zhao S, Cai L (2023) Epigenetic (De) regulation in prostate cancer. Springer Books - Chen (ed.) Epigenetics in Oncology: 321-360.
12. Liu X*, Wang J*, Boyer J, Gong W, Zhao S, Xie L, Wu Q, Zhang C, Jain K, Guo Y, Roderiguez J, Li M, Uryu H, Liao C, Hu L, Zhou J, Shi X, Tsai Y, Yan Q, Luo W, Chen X, Strahl B, Kriegsheim A, Zhang Q, Wang G#, Baldwin A#, Zhang Q# (2022) Histone H3 proline 16 hydroxylation regulates mammalian gene expression. Nat. Genet. 54: 1721-1735
13. Ahn J, Davis E, Daugird T, Zhao S, Quiroga I, Uryu H, Li J, Storey A, Tsai Y, Keeley D, Mackintosh S, Edmondson R, Byrum S, Cai L, Tackett A, Zheng D, Legant W, Phanstiel D#, Wang G# (2021) Phase separation drives aberrant chromatin looping and cancer development. Nature 595: 591-595
14. Guo Y, Zhao S, Wang G (2021) Polycomb gene silencing mechanisms: PRC2 chromatin targeting, H3K27me3 'readout', and phase separation-based compaction. Trends Genet 37(6): 547-565 (Cover Story)
15. Farrelly L, Thompson R, Zhao S, Lepack A, Lyu Y, Bhanu N, Zhang B, Loh Y-HE, Ramakrishnan A, Vadodaria K, Heard K, Erikson G, Nakadai T, Bastle R, Lukasak B, Zebroski III H, Alenina N, Bader M, Berton O, Roeder R, Molina H, Gage F, Shen L, Garcia B, Li H, Muir T, Maze I (2019) Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature 567: 535–539
16. Zhang X, Cao R, Niu J, Yang S, Ma H, Zhao S, Li H (2019) Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3. Cell Discovery 5:35
17. Xiong X, Panchenko T, Yang S, Zhao S, Yan P, Zhang W, Xie W, Li Y, Zhao Y, Allis CD, and Li H (2016) Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2. Nat Chem Biol 12:1111-1118
18. Zhao D, Guan H, Zhao S, Mi W, Wen H, Li Y, Zhao Y, Allis CD, Shi X, and Li H (2016) YEATS2 is a selective histone crotonylation reader. Cell Research 26:629–632
19. Zhao S and Li H (2015) Crystallography-based mechanistic insights into epigenetic regulation. Elsevier Publisher - Zheng (ed.) Epigenetic Technological Applications: 125-147
20. Li H, Zhao S, and Patel D (2015) Histone recognition by tandem modules and modulation by multiple PTMs. Springer Books - Life Sciences and Biomedicine (ed.) Histone Recognition: 149-172
