Education:
1989-1994 B.Sc. in Clinical Medicine, Medical Department, Dalian Medical University
1998-2001 M.Sc in Pathology and Pathophysiology, Capital University of Medical Science
2003-2004 Ph.D in Molecular Biology, School of Medicine, Tokyo University, Japan.
Professional Positions:
1994-1998 Resident physician, Beijing Obstetrics & Gynecology Hospital, affiliated to Capital University of Medical Sciences.
2001-2002 Attending Physicia, Beijing Obstetrics & Gynecology Hospital, affiliated to Capital University of Medical Sciences.
2007-2008 Postdoctoral Fellow, Institute of Cell Biology and Anatomy, School of Med. Univ. of Tokyo,
2008-2015 Assistant research fellow (2008), Lecturer (2012), School of Medicine, Tsinghua University.
2015-2023 Associate Professor, School of Medicine, Tsinghua University.
2024-Now Associate Professor, School of Basic Medical Sciences, Tsinghua University.
Research Areas:
Epigenetic regulation of tumorigenesis
My research focuses on exploring the molecular mechanisms underlying the occurrence and development of tumors. More and more studies have shown that epigenetic regulation abnormalities are closely related to the tumorigenesis. My research focuses on the key roles played by histone modification, DNA methylation, and tumor signaling pathways in gene expression, cell differentiation, and tumorigenesis. We mainly explore the epigenetic regulation of tumorigenic molecular mechanisms through techniques such as cell biology, histopathology, biochemistry, and multi omics, etc.
5）Honors and Awards:
➢ 2022 Special Prize, The 2nd Higher Education Medical Comprehensive Experimental Teaching Design Competition
➢ 2021 Second Prize, The 3rd National College Blended Teaching Design Innovation Competition
➢ 2020 National First Class Undergraduate Online Course
➢ 2020 Beijing University "High Quality Undergraduate Textbook Courseware" Award
➢ 2020 Beijing University "High Quality Undergraduate Course" Award
➢ 2018 "Wonderful Lesson", National Higher Education Innovation and Entrepreneurship Education
➢ 2018 First Prize, Beijing Higher Education Teaching Achievement Award
➢ 2018 Second Prize, Beijing Higher Education Teaching Achievement Award
➢ 2024 2022 2020 Tsinghua University Annual Excellent Teaching Award
➢ 2024 2020 Second Prize, Tsinghua University Excellent Textbook
➢ 2023 Tsinghua University “Lin Feng” Award
➢ 2020 Special Prize, Tsinghua University Online Teaching Outstanding Teacher
➢ 2021 2016 Second Prize, Tsinghua University Teaching Achievement Award
➢ 2020 Third Prize, Tsinghua University Experimental Technology Achievement Award
➢ 2020 Demonstration Course, and Demonstration Teacher, Tsinghua University Course Ideological and Political Education
Selected Publications:
1.Liu W, Yao Q, Su X, Deng Y, Yang M, Peng B, Zhao F, Du C, Zhang X, Zhu J, Wang D*, Li W*, Li H* (2023) Molecular insights into Spindlin1-HBx interplay and its impact on HBV transcription from cccDNA minichromosome. Nat Commun 14:4663-4676. *Corresponding author.
2.Ren X, Zhao Y, Xue Z, Hao N, Li Y, Guo X, Wang D, Shi X, and Li H* (2021) Histone benzoylation serves as an epigenetic mark for DPF and YEATS family proteins. Nucleic Acids Res 49: 114-126
3.Zhao F, Liu Y, Su X, Lee JE, Song Y, Wang D, Ge K, Gao J, Zhang MQ, and Li H* (2020) Molecular basis for histone H3 “K4me3-K9me3/2” methylation pattern readout by Spindlin1. J Biol Chem 295: 16877-16887
4.Zhang Y, Chang JF, Sun J, Chen L, Yang XM, Tang HY, Jing YY, Kang X, He ZM, Wu JY, Wei HM, Wang DL, Xu RG, Zhu RB, Shen Y, Zeng SY, Wang C, Liu KN, Zhang Y, Mao ZY, Jiang CZ, Sun FL* (2018). Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability. J Cell Sci. 131(12).
5.Gao Y, Chen M, Wu J, Zhou Y, Cai C, Wang D*, Luo J * (2017)，Facilitating in vivo tumor detection by principal component analysis based on dynamic fluorescence molecular imaging. Journal of Biomedical Optics. 22(9):1-9. *Corresponding author.
6.Wu J, He Z, Yang XM, Li KL, Wang DL*, Sun FL* (2017). RCCD1 depletion attenuates TGF-β-induced EMT and cell migration by stabilizing cytoskeletal microtubules in NSCLC cells. Cancer Lett. 400:18-29. *Corresponding author.
7.Chen S, Jing Y, Kang X, Yang L, Wang DL, Zhang W, Zhang L, Chen P, Chang JF, Yang XM, Sun FL (2017). Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy. Nucleic Acids Res. 45(3):1144-1158.
8.Wu J, He Z, Wang DL*, Sun FL*(2016). Depletion of JMJD5 sensitizes tumor cells to microtubule-destabilizing agents by altering microtubule stability. Cell Cycle. 15 (21):2980-2991. *Corresponding author.
9.He Z, Wu J, Su X, Zhang Y, Pan L, Wei H, Fang Q, Li H, Wang DL*, Sun FL*(2016). Jumonji Domain Containing 5 (JMJD5) Associates with Spindle Microtubules and Is Required for Proper Mitosis. JBC, 291(9):4684-97. Corresponding author.
10.Wang C, Chang JF, Yan H, Wang DL, Liu Y, Jing Y, Zhang M, Men YL, Lu D, Yang XM, Chen S, Sun FL (2015). A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis. Oncotarget. 6(30):29599-613.
11.Pan L, Xie W, Li KL, Yang Z, Xu J, Zhang W, Liu LP, Ren X, He Z, Wu J, Sun J, Wei HM, Wang D, Xie W, Li W, Ni JQ, Sun FL* (2015). Heterochromatin remodeling by CDK12 contributes to learning in Drosophila. PNAS 112(45):13988-93
12.Chen S, Wang C, Sun L, Wang DL, Chen L, Huang Z, Yang Q, Gao J, Yang XB, Chang JF, Chen P, Lan L, Mao ZY, Sun FL (2015). RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1. Mol Cell Biol. 35(2):406-16.
13.Kanai Y, Wang D, Hirokawa N (2014). KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae. J Cell Biol. 204(3): 395-408.
14.Zhao L, Wang DL, Liu Y, Chen S, Sun FL (2013). Histone acetyltransferase hMOF promotes S phase entry and tumorigenesis in lung cancer. Cell Signal. 25(8): 1689-98.
15.Chen S*, Li J*, Wang DL*, Sun FL (2012). Histone H2B lysine 120 monoubiquitination is required for embryonic stem cell differentiation. Cell Research. 22(9):1402-5. * Co-first authors
16.Liu Y, Wang DL, Chen S, Zhao L and Sun FL (2012). Oncogene Ras/PI3K signaling targets histone H3 acetylation at lysine K56 in tumorigenesis. J Biol Chem. 2012. 30;287(49):41469-80.
17.Chen S, Wang DL, Liu Y, Zhao L, Sun FL* (2012). RAD6 regulates the dosage of p53 by a combination of transcriptional and posttranscriptional mechanism. Mol Cell Biol. 32(2):576-87.
18.Lv WW, Wei HM, Wang DL, Ni JQ and Sun FL (2012). Depletion of histone deacetylase 3 antagonizes PI3K-mediated tissue overgrowth through the acetylation of histone H4 at lysine 16. Journal of Cell Science. 125 (Pt 22): 5369-78.
19.Zhang D, Wang D, Sun F* (2011). Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. Chromosoma. 120(1):97-108. Epub 2010 Sep 21.
20.Zhao L, Gu H, Chang J, Wu J, Wang D, Chen S, Yang X, Qian B (2014). MicroRNA-383 Regulates the Apoptosis of Tumor Cells through Targeting Gadd45g. PLoS One. 9(11).
21.Chen S, Wei HM, Lv WW, Wang DL, Sun FL* (2011). E2 ligase dRad6 regulates DMP53 turnover in Drosophila. J Biol Chem. 286 (11):9020-30.
22.张宇明，王大亮* 马兜铃酸引起上尿路上皮肿瘤（UUC）的病理与治疗回顾，实用肿瘤杂志，2021.36(5):486-491.
