Education:
2000 - 2005 M.D. in Clinical Medicine, Health Science Center, Peking University
2005 - 2011 Ph.D. in Biology, School of Medicine, Tsinghua University
Professional Positions:
2011 - 2014 Post Doctoral, School of Medicine, Tsinghua University
2012 - 2013 Visiting Scholar, University of Pittsburgh, USA
2014 - 2019 Lecturer, School of Medicine, Tsinghua University
2019 - 2024 Associate Professor, School of Medicine, Tsinghua University
2024 - now Associate Professor, School of Basic Medical Sciences, Tsinghua University
Research Areas:
With a focus on drug research and development, Dr. Lan Xie has pioneered the integration of traditional Chinese medicine (TCM) with systems biology, multi-omics, and artificial intelligence (AI) technologies. Together with the research team, she has established the Molecular Materia Medica database and developed an intelligent TCM formulation algorithm based on TCM-derived gene expression profiles and disease-related dysregulated pathways. The related achievements have received several prestigious accolades: the "High-Throughput screening service for TCM bioactive components via transcriptome sequencing" was awarded the Beijing New Technology and New Product (Service) Certification; the " Scientific interpretation of TCM efficacy by single-cell omics and targeted hook " was recognized as one of the Top 10 Academic Progress on TCM in 2022; and the "High-throughput screening and intelligent formulation technology for TCM based on molecular signaling pathways" received the supreme award at the finals of the 2022 National Disruptive Technology Innovation Competition organized by the Torch High-Tech Industry Development Center, Ministry of Science and Technology, China.
Honors and Awards:
➢ 2025 First Prize, Tsinghua University Teaching Achievement Award
➢ 2024 Huaxia Medical Science and Technology Award
➢ 2024 International Award for Contribution to Chinese Medicine
➢ 2024 Model Instructor for Curriculum Ideology & Politics
➢ 2023 China Postdoctoral Innovation & Entrepreneurship Competition
➢ 2019 Outstanding Young Faculty Teaching Award
➢ 2018 China Industry-University-Research Collaborative Innovation Award
➢ 2018 First-Class Award, Outstanding Academic Advisor
➢ 2017 Beijing High-Level Innovative and Entrepreneurial Talent Support Plan
➢ 2017 Second Prize, Excellent Supervisor for Student Research Training (SRT) Program
➢ 2016 First Prize, Tsinghua University Experimental Technology Innovation Award
➢ Annual Teaching Excellence Award (Year 2019, 2022, 2023)
Selected Publications:
"Identification of the fruit of Brucea javanica as an anti-liver fibrosis agent working via SMAD2/SMAD3 and JAK1/STAT3 signaling pathways.” Yan, D., Qiao, L., Huang, W., Zhang, X., Ma, C., Feng, Q., Cheng, J. and Xie, L. Journal of Pharmaceutical Analysis, 2025 Feb;15(2):101047-101051.
"A pumpless liver-on-a-chip for drug hepatotoxicity analysis. " Jiao. D., Xie, L., Xing, W. Catalyst, 2024, Sep 9;149(18):4675-4686.
"Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation. ” Luo, K., Huang, W., Qiao, L., Zhang, X., Yan, D., Ning, Z., Ma, C., Dang, H., Wang, D., Guo, H., Xie, L. and Cheng, J. Acta Pharmaceutica Sinica B, 2022 May;12(5):2239-2251.
"A large-scale transcriptional study reveals inhibition of COVID-19 related cytokine storm by traditional Chinese medicines.” Dai, Y., Qiang, W., Gui, Y., Tan, X., Pei, T., Lin, K., Cai, S., Sun, L., Ning, G., Wang, J., Guo, H., Cheng, J., Xie, L., Lan, X. and Wang, D. Science Bulletin, 2021, May 15;66(9):884-888.
"Evaluation of the immunomodulatory effects of anti-COVID-19 TCM formulae by multiple virus-related pathways.” Qiao, L., Huang, W., Zhang, X., Guo, H., Wang, D., Feng, Q., Jin, R., Xie, L., Li, W. and Cheng, J. Signal Transduction and Targeted Therapy, 2021, Feb 4;6(1):50-53.
