Education:
2005-2010 Peking University，Bachelor in Medicine
2010-2015 Department of Immunology Peking University，Ph.D
Professional Positions:
2015-2021 Postdoctoral School of medicine, Tsinghua University
2021 till now Assistant Research, Basic Medical Sciences, Tsinghua University
Research Areas:
The mechanism of intestinal mucosal immunity and microbiota regulation, especially the mechanism of synergistic regulation of innate lymphoid cells and intestinal microbiota in the process of infection, metabolic diseases, tumorigenesis, etc. Regulation of tumor microenvironment and development of novel immunotherapeutic drugs, focusing on the discovery of regulatory mechanisms and intervention methods of tumor suppressive immune microenvironment, and the reshaping of tumor immune microenvironment through the development of new immunotherapeutic strategy. I have published over 20 research or review articles in prestigious journals such as Cell Stem Cell、Cell Reports、Science Bulletin and JACI.
Honors and Awards:
2013 Aug. IUIS-GATES Foundation Yong Immunologist; 15th International Congress of Immunology.
2013-2014. National Scholarship of China. Twice.
2014 Oct. Peking University Innovation Award.
2015 Apr. Beijing Outstanding Graduate.
2016 Aug. AAI Foundation Travel Grants: 16th International Congress of Immunology.
2016 Nov. Extraordinary Poster Award: Forum on Advancements in Immunology Research.
2015-2021. The Outstanding Scholarship for Post-doc from Tsinghua-Peking Center for Life Science
Selected Publications:
1. Wenyan Wang; Yang-xin Fu ; Promises and Challenges of Organoids: From Humanized to Human Derived, Cell Stem Cell, 2024, 31(3) (co-corresponding author)
2. Wenyan Wang; Na Li; Xiaohuan Guo ; The crosstalk between ILC3s and adaptive immunity in diseases, The FEBS Journal, 2023, 2023(11): 1-13
3. Weiwei Fu*; Wenyan Wang*; Jing zhang; Yang Zhao; Keyan Chen; Ye Wang; Jing Zhang; Ying Xion g; Xiaohuan Guo; Shigang Ding ; Dynamic change of circulating innate and adaptive lymphocytes sub types during a cascade of gastric lesions, JOURNAL OF LEUKOCYTE BIOLOGY, 2022, 112(4): 931-938. (*co-first author)
4. Wenyan, Wang*; Yiping, Li*; Jiacheng, Hao; Yao, He; Xin, Dong; Yang-Xin, Fu; Xiaohuan, Guo ; The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the Mesenteric Lymph Node Restrains Intestinal Humoral Immunity, Cell Reports, 2020, 32(3): 0-107936. (*co-first author)
5. Wenyan, Wang*; Yan, Xing*; Yanmei, Chang; Ying, Wang; Yanxia, You; Zekun, Chen; Defu, Ma; X iaomei, Tong; Xiaohuan, Guo ; The impaired development of innate lymphoid cells by preterm birth is associated with the infant disease, Science Bulletin, 2020, 2021(5): 421-424. (*co-first author)
6. Wang W, Li Y, Guo X. (2020). A Mouse Model of Citrobacter rodentium Oral Infection and the Evaluation of Innate and Adaptive Immune Responses. STAR Protocols. 2020;1(3):100218.
7. Zou Z, Shen J, Xue D, Li H, Xu L, Cao W, Wang W, Fu YX, Peng H. Anti-PD-1 cis-delivery of low-affinity IL-12 activates intratumoral CD8+T cells for systemic antitumor responses. Nat Commun. 2024 Jun 3;15(1):4701.
8. Wang W, Li N, Xu H, Hao J, Huang J, Zhang J, Hu X, Guo X. (2024). Group 3 innate lymphoid cells regulates gut commensal microbiota by glycosylation for the pathogens defense. Nature Microbiology, Revised.
9. Shen J, Zou Z, Guo J, Cai Y, Xue D, Liang Y, Wang W, Peng H, Fu YX. An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery. J Exp Med. 2022 Dec 5;219(12):e20220745.
10. Fu L, Zhao J, Huang J, Li N, Dong X, He Y, Wang W, Wang Y, Qiu J, Guo X. A mitochondrial STAT3-methionine metabolism axis promotes ILC2-driven allergic lung inflammation. J Allergy Clin Immunol. 2022 Jun;149(6):2091-2104.
11. Huang J, Fu L, Huang J, Zhao J, Zhang X, Wang W, Liu Y, Sun B, Qiu J, Hu X, Liu Z, Guo X. Group 3 Innate Lymphoid Cells Protect the Host from the Uropathogenic Escherichia coli Infection in the Bladder. Adv Sci (Weinh). 2022 Feb;9(6):e2103303.
12. Yao He*; Liuhui Fu*; Yiping Li; Wenyan Wang; Mingli Gong; Jing Zhang; Xin Dong; Jiaoyan Hua ng; Quanbo Wang; Charles R Mackay; Yang-Xin Fu; Yun Chen; Xiaohuan Guo ; Gut microbial metabolite s facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity., Cell Metabolism, 2021, 2021(33): 988-1000. (*co-first author)
13. Li T*, Wang W*, Cheng Y, Han W. (2018). Method for quantitative detection of FAM19A4 by flow cytometry using latex beads as solid carrier. J Biosci Bioeng. 2018;125(3):359-364. (*co-first author)
14. Wang W, Li T, Wang X, Yuan W, et al. (2015). FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages. Cell Mol Immunol 2015;12(5):615-624.
15. Wang X*, Wang W*, Lin Z*, Wang X, et al. (2014). CARD9 mutations linked to subcutaneous phaeohyphomycosis and TH17 cell deficiencies. J Allergy Clin Immunol 2014;133(3):905-8.e3.(*co-first authors)
16. Wang X, Li T, Wang W, Yuan W, et al. (2016). Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2. J Immunol. 2016;196(10):4090-4099.
17. Yuan W, Li T, Mo X, Wang X, Liu B, Wang W, Su Y, Xu L, Han W. Knockdown of CMTM3 promotes metastasis of gastric cancer via the STAT3/Twist1/EMT signaling pathway. Oncotarget. 2016 May 17;7(20):29507-19.
18. Li T, Cheng Y, Wang P, Wang W, et al. (2015) CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma. J Exp Clin Cancer Res. 2015;34:122.
19. Li T, Guo X, Wang W, Mo X, et al. (2015). VSTM1 is silenced in human hematopoietic malignancy cell lines with promoter methylation and has inhibitory effects on cell growth. Mol Med Rep. 2015;11(2):1344-1351.
20. Li T, Wang W, Chen Y, Han W. Preparation and characterization of monoclonal antibodies against VSTM1. Monoclon Antib Immunodiagn Immunother. 2013 Aug;32(4):283-9.
