Education:
1988-1993 West China University of Medical Sciences Bachelor of Medicine
1993-1996 Peking Union Medical College Master of Philosophy
1997-2000 Peking Union Medical College Doctor of Medicine
Professional Positions:
1996-1997 Research Fellow, Institute of Transfusion, Chinese Academy of Medical Sciences
2001-2004 Postdoctoral, College of Life Sciences, Peking University
2004-2005 Assistant Professor, Institute of Microbiology, Chinese Academy of Sciences
2005-2008 Postdoctoral, Albert Einstein College of Medicine
2008-2014 Assistant Professor, School of Medicine, Tsinghua University
2014-now Associate Professor, School of Basic Medical Sciences, Tsinghua University
Research Areas:
Dr. Shi has devoted more than 20 years to studying HIV-1 pathogenesis and vaccine development. Recently she expanded her research into emerging and re-emerging human viral pathogens such as SARS-CoV-1, SARS-CoV-2, and MERS-CoV. Using cutting-edge antibody and combinatorial antigen library techniques, she aims to characterize protective antibody immunity in infected humans and rationally design effective antibody therapeutics and vaccines against viral infections.
Selected Publications:
1. Li Mingxi, Guo Jingao, Lu Shuaiyao, Zhou Runhong, Shi Hongyang, Shi Xuanling, Cheng Lin, Liang Qingtai, Liu Hongqi, Wang Pui, Wang Nan, Wang Yifeng, Fu Lili, Xing Man, Wang Ruoke, Ju Bin, Liu Li, Lau Siu-Ying, Jia Wenxu, Tong Xin, Yuan Lin, Guo Yong, Qi Hai, Zhang Qi, Huang Zhen, Chen Honglin, Zhang Zheng, Chen Zhiwei, Peng Xiaozhong, Zhou Dongming, Zhang Linqi. (2021). Single-dose immunization with a chimpanzee adenovirus-based vaccine induces sustained and protective immunity against SARS-CoV-2 infection. Frontiers in Immunology, 12, 1–14. https://doi.org/10.3389/fimmu.2021.697074
2. Ju Bin, Zhang Qi, Ge Jiwan, Wang Ruoke, Sun Jing, Ge Xiangyang, Yu Jiazhen, Shan Sisi, Zhou Bing, Song Shuo, Tang Xian, Yu Jinfang, Lan Jun, Yuan Jing, Wang Haiyan, Zhao Juanjuan, Zhang Shuye, Wang Youchun, Shi Xuanling, Liu Lei, Zhao Jincun, Wang Xinquan, Zhang Zheng, Zhang Linqi. (2020). Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature, 584(7819), 115–119. https://doi.org/10.1038/s41586-020-2380-z
3. Zhou Panpan, Wang Han, Fang Mengqi, Li Yangyang, Wang Hua, Shi Shasha, Li Zihao, Wu Jiapeng, Han Xiaoxu, Shi Xuanling, Shang Hong, Zhou Tongqing, Zhang Linqi. (2019). Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies. PLoS Pathogens, 15(6), 1–24.
4. Jiang Liwei, Wang Nianshuang, Zuo Teng, Shi Xuanling, Poon Kwok Man Vincent, Wu Yongkang, Gao Fei, Li Danyang, Wang Ruoke, Guo Jianying, Fu Lili, Yuen Kwok Yung, Zheng Bo Jian, Wang Xinquan, Zhang Linqi. (2014). Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein. Science Translational Medicine, 6(234). https://doi.org/10.1126/scitranslmed.3008140
5. Wang Nianshuang, Shi Xuanling, Jiang Liwei, Zhang Senyan, Wang Dongli, Tong Pei, Guo Dongxing, Fu Lili, Cui Ye, Liu Xi, Arledge Kelly C., Chen Ying Hua, Zhang Linqi, Wang Xinquan. (2013). Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4. Cell Research, 23(8), 986–993. https://doi.org/10.1038/cr.2013.92
