Education:
1988-1992: Department of biology, Shandong Normal University, Jinan, China
Degree: B.S.
1992--1995: College of Animal Sciences, Northeast Agricultural University, Harbin, China
Degree: M.S.
1997--2000: College of Life Sciences, Peking University, Beijing, China
Degree: Ph.D.
Professional Positions:
2000-2008: the Netherlands Cancer Institute, Amsterdam, the Netherlands. Position: postdoc.
2008-2011: Experimental Animal facility, Biomedical Analysis Center, Tsinghua University.
Position: Head
2011-present: Medical Science Practice Center, School of Medicine, Tsinghua University.
Position: Director
Research Areas:
l Molecular mechanism of familiar breast cancer genesis
l Function of estrogen during breast cancer genesis
l Molecular mechanism of breast tumor metastasis
l Breast cancer genomics and gene therapy
Selected Publications:
1. Marieke van de Ven*, Xiaoling Liu *, Eline van der Burg, Sjoerd Klarenbeek, Xanthippi Alexi 3, Wilbert Zwart, Fred Dijcks, Peter Bouwman and Jos Jonkers. BRCA1 -associated mammary tumourigenesis is dependent on oestrogen rather than progesterone signaling. J Pathology. 2018 Sep;246(1):41-53. doi: 10.1002/path.5105.
*Equal contribution
2. Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P, Peterse JL, Cardiff RD, Berns A, Jonkers J. Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell. 2006 Nov;10(5):437-49.
3. Silver DP, Dimitrov SD, Feunteun J, Gelman R, Drapkin R, Lu SD, Shestakova E, Velmurugan S, Denunzio N, Dragomir S, Mar J, Liu X, Rottenberg S, Jonkers J, Ganesan S, Livingston DM. Further evidence for BRCA1 communication with the inactive X chromosome. Cell. 2007 Mar 9;128(5):991-1002.
4. Wijnhoven SW, Speksnijder EN, Liu X, Zwart E, vanOostrom CT, Beems RB, Hoogervorst EM, Schaap MM, Attardi LD, Jacks T, van Steeg H, Jonkers J, de Vries A. Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage. Cancer Res. 2007 May 15;67(10):4648-56.
5. *Liu X, Holstege H, van der Gulden H, Treur-Mulder M, Zevenhoven J, Velds A, Kerkhoven RM, van Vliet MH, Wessels LF, Peterse JL, Berns A, Jonkers J. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6.
*This article has been highlighted by Nature Reviews Cancer, 2007, Sept. Vol.7: nrc 2213
