Education and Appointments:
(1) 2024-Present, Senior Engineer, School of Basic Medical Sciences, Tsinghua University.
(2) 2021-2024, Senior Engineer, School of Medicine, Tsinghua University.
(3) 2004-2021, Engineer, Tsinghua University, School of Medicine.
(4) 2001-2004, Department of Biology, Tsinghua University.
(5) 1998-2001, Master's Degree in Agronomy, Northwest Agriculture and Forestry University.
(6) 1993-1995, Chemical Engineering, Weinan Normal University.
Research Fields
Research on the molecular mechanisms of tumorigenesis. My research mainly focuses on exploring the functions and mechanisms of tumor-related genes in tumorigenesis. My study explores the key signaling pathways of the tumor-related genes, downstream regulatory genes and their regulatory mechanisms by combining tumor cells themselves with the tumor microenvironment, laying a theoretical foundation for the development of novel tumor - targeted therapies.
Experimental Teaching Courses
(1) Medical Immunology
(2) Comprehensive Experiments in Basic Medicine
(3) Experiments in Medical Cell Biology
(4) Medical Genetics
(5) Magical Immunology
(6) Scientific Research Exploration - The Human Immune Defense System and Modern Immunological Techniques
Book(chapter)s:
(1) Medical Molecular Biology Experimental Technology, 4th Edition, National Health Commission's 13th Five-Year Plan Textbook, Chief Editors: Han Hua, Gao Guoquan, Publisher: People's Medical Publishing House, September 2020. (Writing of Chapter 6）
(2) Comprehensive Experimental Guide for Basic Medicine, Chief Editors: Wang Daliang, Ren Fangli, Wang Yinyin, Publisher: Tsinghua University Press, 2017.
(3) Medical Molecular Biology Experimental Technology, 3rd Edition, National 12th Five-Year Plan Textbook, Chief Editor: Yao Libo, Publisher: People's Medical Publishing House, 2014. (Participate in the writing of Chapter 13）
(4) Ubiquitin-Mediated Protein Degradation, Chief Editor: Qiu Xiaobo, Publisher: Peking Union Medical College Press, 2008. (Participate in the writing of Chapter 2）
Selected Publications
(1) Jianghua Li, Lu Xu, Jiayu Wang, Xuning Wang, Yuting Lin, Alex Yutian Zou, Fangli Ren, Yinyin Wang*, Jun Li*, Zhijie Chang*, CREPT is required for the metastasis of triple-negative breast cancer through a co-operational-chromatin loop-based gene regulation, Molecular Cancer, 202524:170, https://doi.org/10.1186/s12943-025-02361-3.
(2) Yinyin Wang#; Bingdong Zhang; Chunhua He; Bo Tian; Sihan Liu; Jianghua Li; Jiayu Wang; Shigao Yang; Bingtao Zhu; Xiaoguang Wang; Zhijie Chang*; Chenxi Cao*; Cross-Talk between NOK and EGFR: Juxtamembrane and Kinase domain interactions enhancing STAT3/5 signaling in breast cancer tumorigenesis, Translational Oncology, 2025, 52(1): 102276.
(3) Liu Yang#, HaiyanYang, Yunxiang Chu, Yunhao Song, LidanDing, Bingtao Zhu, Wanli Zhai, Xuning Wang, Yanshen Kuang, Fangli Ren, Baoqing Jia, Wei Wu, Xiongjun Ye⁎, Yinyin Wang⁎, Zhijie Chang⁎. CREPT is required for murine stem cell maintenance during intestinal regeneration, Nat Commun. 2021Jan 11;12(1):270. doi: 10.1038/s41467-020-20636-9.
(4) Yinyin Wang#, Sihan Liu, Guancheng Jiang, Wanli Zhai, Liu Yang, Mengdi Li, Zhijie Chang*, Bingtao Zhu*. NOK associates with c-Src and promotes c-Src- induced STAT3 activation and cell proliferation, Cellular Signalling 75 (2020) 109762.。
(5) Yanxia Fu#, Sihan Liu#, Yinyin Wang#, Fangli Ren, Xuanzi Fan, Jiao Liang, Chunxiao Liu, Jun Li, Yanfang Ju, and Zhijie Chang*, GdX/UBL4Aknockout mice resist collagen-induced arthritis by balancing the population of Th1/Th17 and regulatory T cells. FASEB J. 2019 Jul;33(7):8375-8385.
(6) Yutian Zou#, Danhui Ma, Yinyin Wang*. The PROTAC technology in drug development. Cell Biochem Funct. 2019 Jan;37(1):21-30.
(7) Liang, Jiao#; Li, Jun; Fu, Yanxia; Ren, Fangli; Xu, Jiake; Zhou,Mengyu; Li, Peiyu ; Feng, Haotian*; Wang, Yinyin*. GdX/UBL4A null mice exhibit mild kyphosis and scoliosis accompanied by dysregulation of osteoblastogenesis and chondrogenesis. Cell Biochem Funct. 2018.2.20, 36:1~8.
(8) Shigao Yang#, Yinyin Wang#, Kunrong Mei, Sen Zhang, Xiaojun Sun, Fangli Ren, Sihan Liu, Zi Yang, Xinquan Wang, Zhihai Qin, Zhijie Chang. TNFR2–IL-17RD heteromerization reveals a novel mechanism for NF-κB activation. J. Biol. Chem., 2015 Jan 9;290(2):861-71.
(9) Dongdong Lu#, Yinyuan Wu#, Yinyin Wang#, Fangli Ren#, Dianjun Wang, Fuqin Su, Yanquan Zhang, Xi Yang, Guihua Jin, Xinbao Hao, Dacheng He, Yonggong Zhai, David M Irwin, Jim Hu,Joseph JY Sung, Jun Yu, Baoqing Jia, Zhijie Chang. CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle related genes. Cancer Cell. 21,92-104,2012.
(10) Xinbao Hao#, Yinyin Wang#, Fangli Ren, Shanshan Zhu, Yongming Ren, Baoqing Jia, Yi-Ping Li, Yuguang Shi and Zhijie Chang*. SNX25 regulates TGF-β signaling by enhancing the receptor degradation. Cellular Signalling 23(5):935- 946, 2011.
Academic Awards
1. 2023, Tsinghua University Outstanding Experimental Technician Award.
2. August 17, 2022, Grand Prize, 2nd National Higher Education Medical Comprehensive Experimental Teaching Design Competition (Practice Category), Project: "Expression and Functional Identification of Tumor Regulatory Proteins", Awardees: Wang Daliang, Wang Yinyin, Ren Fangli, Chang Zhijie.
3. August 2021, Second Prize for Tsinghua University Teaching Achievement Award, Project: "Innovative Challenges, Excellence in Ethics and Medicine: Teaching Reform and Textbook Development for Challenge-based Courses in Comprehensive Experiments in Basic Medicine", Contributors: Wang Daliang, Wang Yinyin, Ren Fangli, Liu Xiaoling, Chang Zhijie.
4. June 3, 2020, Third Prize for Tsinghua University Experimental Technology Achievement Award, Project: "Virtual Simulation Teaching for Molecular Biology DNA Cloning Technology", Awardees: Wang Daliang, Wang Yinyin, Chang Zhijie, Yang Liu.
5. December 2017, Tsinghua University Challenge-based Course Certification, Course: "Comprehensive Experiments in Basic Medicine", Contributors: Wang Daliang, Wang Yinyin, Chang Zhijie, Ren Fangli, Yang Liu.
6. November 27, 2020, Second Prize for Tsinghua University Outstanding Textbook Award, Textbook: Comprehensive Experimental Guide for Basic Medicine, Awardees: Wang Daliang, Ren Fangli, Wang Yinyin, Chang Zhijie, Ren Ping.
7. 2021, Second Prize for Beijing Higher Education Teaching Achievement Award. Project: "The More Challenging, The More Passionate: Implementing Challenge-based Learning in Medical Immunology Teaching Reform", Awardees: Wu Li, Qi Hai, Wu Ning, Wang Yinyin.
8. 2021, Tsinghua University Top-Quality Course Certification (2021-2025), Course: "Medical Immunology", Faculty : Wu Li, Qi Hai, Wu Ning, Wang Yinyin.
9. 2019, First Prize for Tsinghua University Teaching Achievement Award, Project: "The More Challenging, The More Passionate: Challenge-based Learning in Medical Immunology Teaching Reform", Awardees: Wu Li, Wu Ning, Qi Hai, Wang Yinyin.
10. 2019, Beijing Higher Education Elite Undergraduate Course Project, Course: "Medical Immunology", Team: Wu Li, Wu Ning, Qi Hai, Wang Yinyin.
11. 2016, Tsinghua University Top-Quality Course Certification (2016-2020), Course: "Medical Immunology", Faculty: Wu Li, Qi Hai, Wu Ning, Wang Yinyin.
12. December 2015, Tsinghua University Challenge-based Course Certification (2015), Course: "Medical Immunology", Faculty: Wu Li, Qi Hai, Wu Ning, Wang Yinyin.
