Education:
1978-1982 |
Bachelor of Medicine, Beijing Medical University, China. |
1983-1985 |
M.MedSci, Beijing Medical University, China |
1987-1991 Professional positions: |
PhD. In Medical Biology, University of Melbourne, Australia. |
1991-1996 |
Postdoctoral and Senior Postdoctoral research fellow Lymphocyte Differentiation Unit, Walter and Eliza Hall Institute (WEHI), Melbourne, Australia. |
1997-2000 |
Research Fellow (Faculty) Immunology Division, WEHI, Melbourne, Australia. |
2001-2005 |
Chung-Kung Scholar Program Professor (Chinese Ministry of Education) Peking University Health Science Center, China. |
2001-2010 |
Senior Research Fellow Laboratory Head, Immunology Division, WEHI, Melbourne, Australia. |
2010-present |
Professor (Tenured) Tsinghua University School of Medicine, Beijing, China. |
2014-present |
Deputy Director, Institute for Immunology Tsinghua University, Beijing, China |
Research Interests
² Molecular regulation of immune cell lineage commitment and differentiation from the hematopoietic stem and progenitor cells.
² Dendritic cell differentiation and function in homeostasis and diseases.
² The roles of innate immune cells in tumor microenvironment.
Selected Publications：total >160, H-index=65, citation >23,000
1. Wu L, Scollay R, Egerton M, Pearse M, Spangrude GJ, Shortman K. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 349: 71-74, 1991.
2. Wu L, Antica M, Johnson GR, Scollay R, Shortman K. Developmental potential of the earliest precursor cells from the adult mouse thymus. J Exp Med 174: 1617-1627, 1991.
3. Ardavin C, Wu L, Li C-L, Shortman K. Thymic dendritic cells and T cells develop simultaneously within the thymus from a common precursor population. Nature 362: 761-763, 1993.
4. Wu L, Nichogainnopoulou A, Shortman K, Georgopoulos K. Cell autonomous defects in udendritic cell populations of ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity, 7:483-492, 1997.
5. Wu L, D’Amico A, Winkel K.D, Suter M, Lo D, Shortman K. RelB is essential for the development of Myeloid-related CD8a- dendritic cells but not of lymphoid-related CD8a+ dendritic cells. Immunity, 9:839-847, 1998.
6. Wu L, D'Amico A, Hochrein H, O’Keeffe M, Shortman K and Lucas K. Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. Blood, u98:3376-3382, 2001.
7. D’Amico A and Wu L. The Early Progenitors of Mouse Dendritic Cells and Plasmacytoid pre-Dendritic Cells are within the Bone Marrow Hemopoietic Precursors Expressing Flt3. J. Exp. Med. 198:293-303, 2003.
8. Nutt S. L, Metcalf D., D’Amico A., Polli M. and Wu L. Dynamic Regulation of PU.1 Expression in Multipotent Hematopoietic Progenitors. J. Exp. Med. 201:221-231, 2005.
9. Naik SH, Proietto AI, Wilson NS, Dakic A, Schnorrer P, Fuchsberger M, Lahoud MH, O’Keeffe M, Shao QX, Chen WF, Villadangos JA, Shortman K, and Wu L. Cutting Edge: Generation of Splenic CD8+ and CD8- Dendritic Cell Equivalents in Fms-Like Tyrosine Kinase Ligand Bone Marrow Cultures. J. Immunol. 174:6592-6597, 2005.
10. Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, & Visvader JE. Generation of a functional mammary gland from a single stem cell. Nature. 439:84-88. 2006.
11. Naik SH, Sathe P, Park H-Y, Metcalf D, Anna I. Proietto AI, Dakic A, Carotta S, O’Keeffe M, Bahlo M, Papenfuss A, Kwak J-Y, Wu L and Shortman K. Development of plasmacytoid and conventional dendritic cell subtypes from single in vitro and in vivo- derived precursors. Nat. Immunol. 8:1217, 2007.
12. Wu L and Liu YJ. The Development of Dendritic Cell Lineages. Immunity. 26:741-750. 2007.
13. Proietto AI, van Dommelen S, Zhou P, Rizzitelli A, D'Amico A, Steptoe RJ, Naik SH, Lahoud MH, Liu Y, Zheng P, Shortman K and Wu L. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc Natl Acad Sci. USA. 105:19869-19874, 2008.
14. Carotta S., Dakic A., D’Amico A., Pang SHM., Greig KT, Nutt SL and Wu L. The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose Dependent Manner. Immunity. 28:628-41, 2010.
15. Wu L. A Flt3L Encounter: mTOR Signaling in Dendritic Cells. Immunity. 33:580-582, 2010.
16. Zhou HB, Xiao J, Wu N, Liu CX, Xu J, Liu F and Wu L. MicroRNA-223 Regulates the Differentiation and Function of Intestinal Dendritic cells and Macrophages by targeting C/EBPβ. Cell Reports 2015 Nov 10;13(6):1149-60. doi: 10.1016/j.celrep.2015.09.073.
17. Guo XH, Wu N, Shang YL，Liu X, Wu T, Zhou YF, Liu X, Huang JY, Liao XB and Wu L. The novel Toll-like receptor 2 agonist SUP3 enhances antigen Presentation and T cell activation by Dendritic cells. Front. Immunol. 8:158. doi: 10.3389/fimmu. 2017.00158.
18. Wu T and Wu L. Dendritic Cell Fate Determination Revealed by “SISter” Assays. Immunity. doi.org/10.1016/j.immuni.2021.05.012.
19. Tian YJ#, Lv JY#, Su ZY, Wu T, Li XG, Hu XY, Zhang JH, Wu L. LRRK2 plays essential roles in maintaining lung homeostasis and preventing the development of pulmonary fibrosis. PNAS 2021, Vol. 118 No. 35 e2106685118, https://doi.org/10.1073/pnas.2106685118.
20. Zhang Y, Wu T, He Z, Lai W, Shen X, Lv J, Wang Y and Wu L. Regulation of pDC fate determination by histone deacetylase. eLife, 2023, DOI: https://doi.org/10.7554/eLife.80477
