Education:
1995-1999 Beijing University, B.S
1999-2005 Harvard University, Ph.D
Professional Positions:
2006-2011 Postdoctor National Institutes of Health, USA
2012-2019 Researcher Institute of Biophysics, Chinese Academy of Sciences
2020-2024 Associate Professor, School of Medicine, Tsinghua University, Beijing, China
2024-now Associate Professor, School of Basic Medical Sciences, Tsinghua University, Beijing, China
Research Interests:
We co-exist as superorganism with our microbiota. Our research interest aims to understand how microbiota regulates host physiology. We employs gnotobiotic techniques to identify the microbial metabolites and employs mouse genetics to dissect the underlying molecular pathways of microbial-host crosstalk.
Research Areas:
1.Intestinal macrophage and T/B cell differentiation, migration and expansion
2.Microbiota recognition and control by intestinal macrophage
3.In inflammatory bowel disease (IBD), the mechanism of macrophage regulating T cell differentiation
4.The mechanistic studies of IBD susceptible genes
5.The role of macrophage in colon cancer
Honors and Awards:
1999-2002 Full fellowship, Harvard University
2012 “Thousand People Plan”
2012 Chinese Academy of Sciences - Novo Nordisk Great Wall Professorship
2015 National Excellent Youth Fund
2018 Youth Award of Chinese biologists Association
Selected Publications:
1. Yinghui Li, Xingchen Liu, Xue Sun, Hui Li, Shige Wang, Wotu Tian, Chen Xiang, Xuyuan Zhang, Jiajia Zheng, Haifang Wang, Liguo Zhang, Li Cao*, Catherine CL Wong* and Zhihua Liu*(2024). Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration. Protein & Cell accepted.
2. Chengye Zhang, Chen Xiang, Kaichen Zhou, Xingchen Liu, Guofeng Qiao, Yabo Zhao, Kemeng Dong, Ke Sun, and Zhihua Liu*(2024).
Intestinal Lysozyme1 Deficiency Alters Microbiota Composition and Impacts Host Metabolism Through the Emergence of NAD+-Secreting ASTB Qing110 Bacteria. mSystems 2024 Mar 19;9(3).
3. Haiyuan Shen,Liangliang Zhou,Hao Zhang,Yuanru Yang,Ling Jiang,Dongqing Wu,Hang Shu,Hejiao Zhang,Linxi Xie,Kaichen Zhou,Chen Cheng,Lei Yang,Jiali Jiang,Siya Wang,Yiran Han,Jiayi Zhu,Long Xu,Zhihua Liu* ,Hua Wang* ,and Shi Yin*（2024）. Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification. Cell Host&Microbe 32, 1-16.
4. Dongju Wang, Haifang Wang, Wei Wan, Zihui Zhu, Takami Sho, Yi Zheng,Xing Zhang, Longyu Dou, Qiang Ding, Li Yu* & Zhihua Liu*(2024). Engineered Migrasomes: A Robust, Thermally Stable Vaccination Platform. eLife accepted.
5. Lingjuan Jiang,Mengmeng Shang,Shengnan Yu,Yudong Liu,Hui Zhang,Yangzhong Zhou,Min Wang,Tingting Wang,Hui Li,Zhihua Liu*and Xuan Zhang*(2023). A high-fiber diet synergizes with Prevotella copri and exacerbates rheumatoid arthritis. Cell Mol Immunol 19, pages1414–1424 (2022).
6. Dong Wu,Kaichen Zhou,Meng Xiao,Zhihua Liu*,Shuyang Zhang*(2022). Differences in intestinal microbiome are associated with the mortality of COVID-19 patients in intensive care units. Science China Life sciences Jan 26.
7. Chen Xiang,Peihua Chen, Qin Zhang, Yinghui Li,Ying Pan, Wenchun Xie,Jianyuan Sun,Zhihua Liu*(2021). Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells. iScience 2021 Aug 20.
8. Haifang Wang, Xueying Shen, Xiaojiao Zheng, Ying Pan, Qin Zhang, Zhihua Liu*(2021). Intestinal lysozyme releases Nod2 ligand(s) to promote the intestinal mucosal adjuvant activity of cholera toxin. Science China Life sciences 2021 Jan 29.
9. Jiaying Yu, Xin He, Aihua Wei, Teng Liu, Qin Zhang, Ying Pan, Zhenhua Hao, Lin Yang, Yefeng Yuan, Zhao Zhang, Chang Zhang, Chanjuan Hao, Zhihua Liu*, Wei Li*(2020). HPS1 Regulates the Maturation of Large Dense Core Vesicles and Lysozyme Secretion in Paneth Cells. Frontiers in immunology 2020 Nov 5;11:560110.
10. Qin Zhang, Ying Pan, Benhua Zeng, Xiaojiao Zheng, Haifang Wang, Xueying Shen, Hui Li, Qian Jiang, Jiaxu Zhao, Zhuo-Xian Meng, Pingping Li, Zhengjun Chen, Hong Wei* and Zhihua Liu*(2019). Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells, Cell research 2019 July;29(7):516-532.
11. Haifang Wang, Xinwen Zhang, Zhanguang Zuo, Qin Zhang, Ying Pan, Benhua Zeng, Wenxia Li, Hong Wei*, and Zhihua Liu*(2017). Rip2 Is Required for Nod2-Mediated Lysozyme Sorting in Paneth Cells, The Journal of Immunology 2017 May 1;198(9):3729-3736.
12. Ruiqing Yan, Zhihua Liu*(2017). LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation, Protein & Cell 2017 January; 8(1):55-66.
13. Qin Zhang, Ying Pan1, Ruiqing Yan, Benhua Zeng, Haifang Wang, Xinwen Zhang, Wenxia Li,Hong Wei* and Zhihua Liu*(2015). Commensal bacteria direct selective cargo sorting to promote symbiosis. Nat Immunol 2015 Sep; 16(9):918-26.
14 Hyun Jin Cho, Jia Yu, Chengsong Xie, Parvathi Rudrabhatla, Xi Chen, Junbing Wu, Loukia Parisiadou, Guoxiang Liu, Lixin Sun, Bo Ma, Jinhui Ding, Zhihua Liu* and Huaibin Cai*(2014). Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.EMBO J. 2014 Oct 16;33(20):2314-31.
