Education:

1978-1983 B.Sc. China Agricultural University

1987-1991 Ph.D. School of Medicine, Gunma University, Japan

Professional Positions:

1993-1997 Postdoctoral fellow, La Jolla Institute for Allergy and Immunol., CA, USA

1997-1998 Instructor, La Jolla Institute for Allergy and Immunol.

1999-2020 Assistant Professor (1999), Associate Professor (2002), Associate Professor with tenure (2006), Professor (2009), La Jolla Institute for Allergy and Immunol.

2013-2024 Professor, School of Medicine, Tsinghua University, Beijing, China

2024-now Professor, School of Basic Medical Sciences, Tsinghua University, Beijing, China

Research Areas:

My research aims to understand the regulatory mechanism of protein ubiquitination in the immune system. Protein ubiquitination is an important post-translational modification process, which is involved in cell cycle, proliferation, apoptosis, differentiation, signaling, and damage repair. The dysregulation of the ubiquitination process may lead to abnormal degradation or accumulation of proteins, which in turn leads to the pathogenesis of a variety of diseases. Our laboratory focuses on the development and function of Th2 cells, regulatory T cells, and type 2 innate lymphoid cells, the metabolic regulation of immune cells, and their roles in immunological diseases such as allergic and autoimmune diseases. I have served as an editor of Molecular and Cellular Biology since 2009, an associate editor of Journal of Immunology (2009-2013), and a member of NIH Cellular and Molecular Immunology-A study section (2010-2014).

Honors and Awards:

2019-2014 Elsevier most cited Chinese researchers

Selected Publications:

1.Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity. Han J, Wan Q, Seo GY, Kim K, El Baghdady S, Lee JH, Kronenberg M, Liu YC*. J Exp Med. 2022 Jun 6;219(6).

2.The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control. Zhu Y, Zhao Y, Zou L, Zhang D, Aki D, Liu YC*. J Exp Med. 2019 Jul 1;216(7):1664-1681.

3.The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. Zhang W, Li Q, Li D, Li J, Aki D, Liu YC*. J Exp Med. 2018 Dec 3;215(12):3180-3193.

4.The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR. Aki D#, Li H#, Zhang W#, Zheng M, Elly C, Lee JH, Zou W, Liu YC*. Nat Immunol. 2018 Jul;19(7):766-775.

5.E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor. Li Q#, Li D#, Zhang X#, Wan Q, Zhang W, Zheng M, Zou L, Elly C, Lee JH, Liu YC*. Immunity. 2018 Feb 20;48(2):258-270.e5.

6.SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex. Park Y, Jin HS, Lopez J, Lee J, Liao L, Elly C, Liu YC*. Nat Immunol. 2016 Mar;17(3):286-96.

7.E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity. Lee JH, Elly C, Park Y, Liu YC*. Immunity. 2015 Jun 16;42(6):1062-74.

8.The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells. Xiao N, Eto D, Elly C, Peng G, Crotty S, Liu YC*. Nat Immunol. 2014 Jul;15(7):657-66.

9.K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling. Huang H, Jeon MS, Liao L, Yang C, Elly C, Yates JR 3rd, Liu YC*. Immunity. 2010 Jul 23;33(1):60-70.

10.The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC. Science. 1999 Oct 8;286(5438):309-12.