Education:
2002-2007 B.M. in Basic Medical Sciences, Peking University, Beijing, China
2007-2010 Ph.D. in Immunology, Peking University, Beijing, China
Professional Positions:
2010-2015 Postdoctoral Scholar, Department of Pathology, The University of Chicago, Chicago, USA
2015-2021 Assistant Professor, School of Medicine, Tsinghua University, Beijing, China
2015-now Principal Investigator, Institute for Immunology, Tsinghua University, Beijing, China
2021-now Associate Professor, School of Basic Medical Sciences, Tsinghua University, Beijing, China
Research Areas:
His research has been focused on the regulation of mucosal immunity and gut microbiota homeostasis, especially the complex interactions and molecular mechanisms between gut-enriched group 3 innate lymphoid cell (ILC3) and other cells, food, normal microbiota, and pathogens. His lab has identified several key factors in regulating ILC3 development and function, found several novel roles and mechanisms of ILC3 in mucosal homeostasis and various diseases, discovered the important role of gut microbiota and their metabolites in the intestinal infectious and inflammatory diseases and also the efficacy of anti-tumor therapies. Up to date, he has published over 40 papers including corresponding-author research articles in journals such as in Immunity, Cell Metabolism, Nature Communications, Science Bulletin and Cell Reports.
Honors and Awards:
➢ 2023 “Emerging leader in mucosal immunology” by Mucosal Immunology Journal
➢ 2022 2021 Chinese Scientists with Cell Press Best Paper Award
➢ 2021 Outstanding Young Investigator Award, National Natural Science Foundation of China
➢ 2021 Excellent Doctoral Dissertation Supervisor of Tsinghua University
➢ 2020 Young Scholar Award of Beijing Society of Immunology
➢ 2015 International Congress of Mucosal Immunology Travel Award
Selected Publications:
1. Panwei Song, Zhi Peng*, Xiaohuan Guo*. Gut microbial metabolites in cancer therapy. Trends in Endocrinology & Metabolism. (2024).
2. Jiacheng Hao, Chang Liu, Zhijie Gu, Xuanming Yang, Xun Lan, Xiaohuan Guo*. Dysregulation of Wnt/β-catenin Signaling Contributes to Intestinal Inflammation through Regulation of Group 3 Innate Lymphoid Cells. Nature Communications. (2024) 15, 2820.
3. Jiaoyan Huang, Xin Zhang, Hongkai Xu, Liuhui Fu, Yuke Liu, Jie Zhao, Jida Huang, Zuodong Song, Mingzhao Zhu, Yang-Xin Fu, Ye-Guang Chen, Xiaohuan Guo*. Intraepithelial Lymphocytes Promote Intestinal Regeneration through CD160/HVEM Signaling. Mucosal Immunology. (2024) 17 (2): 257-271.
4. Yi-tong Hu, Xing-zi Liu, Yue-miao Zhang*, Xiaohuan Guo*. The interaction network between group 3 innate lymphoid cells and other cells. Fundamental Research. In press.
5. Wenyan Wang, Na Li, Xiaohuan Guo*. The Crosstalk between ILC3s and Adaptive Immunity in Diseases. The FEBS Journal. (2023).
6. Xin Chen, Chengcheng Jin, Andrea Facciabene, Xiaohuan Guo, Yanbo Zhang. Editorial: Deciphering the Microbiome-Immunity-Cancer Axis. Frontiers in Immunology. (2022) 13: 897811.
7. Liuhui Fu, Jie Zhao, Jiaoyan Huang, Na Li, Xin Dong, Yao He, Wenyan Wang, Yu Wang, Ju Qiu, Xiaohuan Guo*. A mitochondrial STAT3-methionine metabolism axis promotes ILC2-driven allergic lung inflammation. Journal of Allergy and Clinical Immunology. (2022) 149 (6): 2091-2104.
8. Jiaoyan Huang, Liuhui Fu, Jida Huang, Jie Zhao, Xin Zhang, Wenyan Wang, Yeyang Liu, Bowen Sun, Ju Qiu, Xiaoyu Hu, Zhihua Liu, Xiaohuan Guo*. Group 3 innate lymphoid cells protect the host from the uropathogenic Escherichia coli infection in the bladder. Advanced Science. (2022) 9: 2103303.
9. Yao He, Liuhui Fu, Yiping Li, Wenyan Wang, Mingli Gong, Jing Zhang, Xin Dong, Jiaoyan Huang, Quanbo Wang, Charles R. Mackay, Yang-Xin Fu, Yun Chen, Xiaohuan Guo*. Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity. Cell Metabolism. (2021) 33(5): 988–1000.
10. Wenyan Wang, Yan Xing, Yanmei Chang, Ying Wang, Yanxia You, Zekun Chen, Defu Ma*, Xiaomei Tong*, Xiaohuan Guo*. The Impaired Development of Innate Lymphoid Cells by Preterm Birth Is Associated with the Infant Disease. Science Bulletin. (2021) 66: 421-424.
11. Wenyan Wang*, Yiping Li, Xiaohuan Guo*. A Mouse Model of Citrobacter rodentium Oral Infection and Evaluation of Innate and Adaptive Immune Responses. STAR Protocols. (2020) 1(3):100218.
12. Wenyan Wang, Yiping Li, Jiacheng Hao, Yao He, Xin Dong, Yang-Xin Fu, Xiaohuan Guo*. The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the mLN Restrains Intestinal Humoral Immunity. Cell Reports. (2020) 32(3): 107936.
13. Xiaohuan Guo*, Yang-Xin Fu*. The tragic fate of group 3 innate lymphoid cells during HIV-1 infection. J Clin Invest (2015) 125(9):3430-2.
14. Xiaohuan Guo*, Yong Liang, Yuan Zhang, Anna Lasorella, Barbara L. Kee, Yang-Xin Fu*. Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2−Dependent Regulation of Microbiota. Immunity (2015) 42(1): 731–743.
15. Xiaohuan Guo, Ju Qiu, Tony Tu, Xuanming Yang, Liufu Deng, Robert A. Anders, Liang Zhou, and Yang-Xin Fu. Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection. Immunity (2014) 40(1): 25–39.
(*, corresponding author; #, co-first Author)
