Education:
1994-1998 B.Sc. in Chemistry, Department of Chemistry, Peking University
1998-2003 Ph.D. in Molecular biology and biochemistry, Institute of Biophysics, Chinese Academy of Sciences
Professional Positions:
2005-2012 Postdoc (2005), Research Assistant Scientist (2010), Purdue University, Indiana, USA
2013-2018 Assistant Professor, School of Medicine, Tsinghua University, Beijing, China
2018-2024 Associate Professor, School of Medicine, Tsinghua University, Beijing, China
2024-now Associate Professor, School of Basic Medical Sciences, Tsinghua University, Beijing, China
Research Areas:
The long-term goal of the research group is to understand the molecular mechanisms underlying virus assembly and infection, and perform structure directed vaccine development. The group mainly uses biochemical, biophysical and AI-based approaches for the studies.
Honors and Awards:
➢ 2019 NSF Distinguished Young Scholars of China
➢ 2013 Young Scholar
Selected Publications:
1.Duanfang Cao, Bingting Ma, Ziyi Cao, Xiaoyu Xu, Xinzheng Zhang*, Ye Xiang*. The receptor VLDLR binds Eastern Equine Encephalitis virus through multiple distinct modes. Nature Communications, 2024 15:6866.
2.Qi Jia, Ye Xiang*. Cryo-EM structure of a bacteriophage M13 mini variant. Nature Communications, 2023 14:5421.
3.Duanfang Cao, Bingting Ma, Ziyi Cao, Xinzheng Zhang*, Ye Xiang*. Structure of Semliki Forest virus in complex with its receptor VLDLR. Cell, 2023 186(10):2208-2218.
4.Silian Chen, Miao Rong, Yun Lv, Deyu Zhu*, Ye Xiang*. Regulation of cGAS activity by RNA-modulated phase separation. EMBO reports, 2023 24(2):e51800.
5.Bingting Ma, Cuiqing Huang, Jun Ma, Ye Xiang*, Xinzheng Zhang*. Structure of Venezuelan equine encephalitis virus with its receptor LDLRAD3. Nature, 2021 598(7882):677-681.
6.Jingjing Gao, Miao Gui*, Ye Xiang*. Structural intermediates in the low pH-induced transition of influenza hemagglutinin. PLoS Pathog., 2020 16(11):e1009062.
7.Qi Liu, Bingting Ma, Nianchao Qian, Fan Zhang, Xu Tan, Jianlin Lei, Ye Xiang*. (2019). Structure of the African Swine Fever Virus major capsid protein p72. Cell Research, 2019 29:953-955.
8.Jingwei Xu, Dianhong Wang, Miao Gui, Ye Xiang*. Structural assembly of the tailed bacteriophage varphi29. Nat Communications, 2019 10:2366.
9.Jingwei Xu, Nir Dayan, Amir Goldbourt*, Ye Xiang*. Cryo-electron microscopy structure of the filamentous bacteriophage IKe. Proc Natl Acad Sci U S A., 2019 116(12):5493-5498.
10.Wenfei Song, Miao Gui, Xinquan Wang*, Ye Xiang*. Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. PLoS pathogens, 2018 14(8):e1007236. Google citation: 995.
11.Miao Gui, Wenfei Song, Haixia Zhou, Jingwei Xu, Silian Chen, Ye Xiang*, Xinquan Wang*. Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding. Cell Research, 2017 27(1):119-129. Google citation: 673.
12.Jingwei Xu, Miao Gui, Dianhong Wang, Ye Xiang*. The bacteriophage phi29 tail possesses a pore-forming loop for cell membrane penetration. Nature, 2016 534(7608):544-547.
