Education:
2003-2007 B.Sc., Southwest University
2007-2013 Ph.D., Institut Pasteur of Shanghai, Chinese Academy of Sciences
Professional Positions:
2014-2018 Postdoctoral Research associate, Princeton University, USA
2018-2021 Assistant Professor, School of Medicine, Tsinghua University, Beijing, China
2021-now Associate Professor, School of Basic Medical Sciences, Tsinghua University, Beijing, China
Research Areas:
Dr. Qiang Ding’s group primarily focuses on RNA viruses that pose significant threats to human health. Utilizing techniques such as molecular biology, reverse genetics, genomics, and proteomics, we delve into the life cycles of these viruses, identifying crucial host factors essential for viral infection and antiviral factors that inhibit viral replication. We aim to reveal the molecular mechanisms underlying virus-host tropism and tissue specificity, laying the groundwork for the development of antiviral drugs, disease prevention, and the generation of experimental animal models.
Specific research areas include: 1. Identification of proviral host factors or restriction factors for viral infection; 2. Identification of host factors regulation of viral host tropisim; 3. Development of animal models conducive to viral infection, providing robust tools for the development of antiviral drugs and vaccines.
Honors and Awards:
➢ 2021 Award of Changjiang Young Scholars Program by the Ministry of Education
Selected Publications:
1.Ren, W., Fu, C., Zhang, Y., Ju, Xiao., Jiang, X., Song, J., Gong, M., Li, Z., Fan, W., Yao, J., and Ding, Q. Zika Virus NS5 Protein Inhibits Type I Interferon Signaling via CRL3 E3 ubiquitin Ligase-Mediated Degradation of STAT2. PNAS (2024)
2. Zhu, Z., Han, Y., Gong, M., Sun, B., Zhang, R., and Ding, Q. Establishment of replication-competent vesicular stomatitis virus recapitulating SADS-CoV entry. Journal of Virology doi: 10.1128/jvi.01957-23 (2024)
3. Song, J., Hong, J., Yang, C., Zhang, Y., Li, Z., He, P., and Ding, Q. Recapitulation of the Powassan virus life cycle in cell culture. mBio 15: e03468-23 (2024)
4. Ju, X., Wang, Z., Wang, P., Ren, W., Yu, Y., Yu, Y., Yuan, B., Song, J., Zhang, X., Zhang, Y., Xu, C., Tian, B., Shi, Y., Zhang, R., and Ding, Q. SARS-CoV-2 main protease cleaves MAGED2 to antagonize host antiviral defense. mBio 14(4): e0137323 (2023)
5. Ju, X., Yu, Y., Ren, W., Dong, L., Meng, X., Deng, H., Nan, Y., and Ding, Q. The PRMT5/WDR77 complex restricts hepatitis E virus replication. PLoS Pathogens 19(6): e1011434 (2023)
6. Ren, W., Zhang, Y., Rao, J., Wang, Z., Lan, J., Liu, K., Zhang, X., Hu, X., Yang, C., Zhong, G., Zhang, R., Wang, X., Shan, C.*, and Ding, Q*. Evolution of Immune Evasion and Host Range Expansion by the SARS-CoV-2 B.1.1.529 (Omicron) Variant. mBio 14: e00416-23 (2023) (*, co-corresponding author)
7. Ren, W., Zhu, Y., Lan, J., Chen, H., Wang, Y., Shi, H., Feng, F., Chen, D., Close, B., Zhao, X., Wu, J., Tian, B., Yuan, Z., Zhou, D., Saeed, M., Wang, X.*, Zhang, R.*, and Ding, Q*. Susceptibilities of Human ACE2 Genetic Variants in Coronavirus Infection. Journal of Virology 96(1): e01492-21 (2022) (*, co-corresponding author)
8. Ren, W., Ju, X., Gong, M., Lan, J., Yu, Y., Long, Q., Kenney, D., O’Connell, A., Zhang, Y., Zhong, J., Zhong, G., Douam, F., Wang, X., Huang, A., Zhang, R., and Ding, Q. Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion. mBio doi: 10.1128/mbio.00099-22 (2022)
9. Gong, M., Yang, Y., Huang, Y., Gan, T., Wu, Y., Gao, H., Li, Q., Nie, J., Huang, W., Wang, Y., Zhang, R., Zhong, J., Deng, F., Rao, Y.*, and Ding Q*. Novel quinolone derivatives targeting human dihydroorotate dehydrogenase suppress Ebola virus infection in vitro. Antiviral Research 194: 105161 (2021) (*, co-corresponding author)
10. Ren, W., Lan, J., Ju, X., Gong, M., Long, Q., Zhu, Z., Yu, Y., Wu, J., Zhong, J., Zhang, R., Fan, S., Zhong, G., Huang, A., Wang, X.*, and Ding, Q*. Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption. PLoS Pathogens doi: 10.1371/journal.ppat. 1010053 (2021) (*, co-corresponding author)
11. Sun, L., Li, P., Ju, X., Rao, J., Huang, W., Ren, L., Zhang, S., Xiong, T., Xu, K., Zhou, X., Gong, M., Miska, E., Ding, Q.*, Wang, J.*, and Zhang, Q*. In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs. Cell 184: 1-19 (2021) (*, co-corresponding author)
12. Liu, Y., Hu, G., Wang, Y., Ren, W., Zhao, X., Ji, F., Zhu, Y., Feng, F., Gong, M., Ju, X., Zhu, Y., Cai, X., Lan, J., Guo, J., Xie, M., Dong, L., Zhu, Z., Na, J., Wu, J., Lan, X., Xie, Y., Wang, X., Yuan, Z.*, Zhang, R.*, and Ding, Q*. Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2. PNAS 118(12): e2025373118 (2021) (*, co-corresponding author)
13. Ju, X., Zhu, Y., Wang, Y., Li, J., Zhang J., Gong, M., Ren, W., Li, S., Zhong, J., Zhang, Q., Zhang, R., and Ding, Q. A novel cell culture system modeling the SARS-CoV-2 life cycle. PLoS Pathogens doi: 10.1101/2020.12.13.422469 (2021)
14. Ren, W., Hu, G., Zhao, X., Wang, Y., Shi, H., Lan, J., Zhu, Y., Wu, J., Kenney, D., Florian, D., Tong, Y., Zhong, J., Xie, Y., Wang, X., Yuan, Z., Zhou, D., Zhang, R.*, and Ding, Q.*, Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry. PLoS Pathogens doi: 10.1101/2020.09.20.297242 (2021) (*, co-corresponding author)
15. Ju, X., Xiang, G., Gong, M., Yang, R., Qin, J., Li, Y., Nan, Y., Yang, Y., Zhang, Q., and Ding, Q. Indentification of functional cis-acting RNA elements in the hepatitis E virus genome required for viral replication. PLoS Pathogens 16: e1008488 (2020)
16. Ju, X., and Ding, Q. Hepatitis E Virus Assembly and Release. Viruses 11: 539 (2019)
