Education:
1992-1997 Bachelor in Medicine. Peking University School of Medicine, P. R. China.
1997-2002 Ph.D. in Cell Biology, School of Medicine, University of Virginia, USA
Professional Positions:
2002-2005 Wellcome Trust Postdoc Research Associate. The Wellcome Trust Gurdon Institute, University of Cambridge, United Kingdom.
2006-2010 Royal Society and MRC Career Development Fellow, Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, United Kingdom.
2010-2019 Assistant and Associate Professor, School of Medicine, Tsinghua University, Beijing, China
2019-now Tenured Associate Professor, School of Basic Medical Sciences, Tsinghua University, Beijing, China
Research Areas:
1. The regulatory mechanism of human pluripotent stem cells (hPSCs) differentiation to cardiovascular and immune cell types including cardiomyocytes, endothelial cells and macrophages. Using hPSC-derived cells to make human disease models for drug discovery and testing, cell and gene therapy.
2. Developmental regulation of early mammalian embryos, study genetic mutations affecting early human embryo development.
3. Organoid engineering and translational research.
Honors and Awards:
➢ 2019 Chinese Ministry of Education Scientific Research Excellency 1st Class Award
➢ 2010 Wellcome Trust Value in People Award
Selected Publications:
1. Mengda Li, Peiliang Wang, Si Tong Huo, Hui Qiu, Chendi Li, Siyong Lin, Libin Guo, Yicong Ji, Yonglin Zhu, Jinyang Liu, Jianying Guo, Jie Na* and Yuntao Hu*. Human pluripotent stem cells derived endothelial cells repair choroidal ischemia. Advanced Science. 2023, 2302940
2. Chen X, Wang P, Qiu H, Zhu Y, Zhang X, Zhang Y, Duan F, Ding S, Guo J, Huang Y, Na J*. Integrative epigenomic and transcriptomic analysis reveals the requirement of JUNB for hematopoietic fate induction. Nature Communications, 2022, 13:3131, doi:10.1038/s41467-022-30789-4
3. Huang R, Liu J, Chen X, Zhi Y, Ding S, Ming J, Li Y, Wang Y, and Na J. A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions. Protein Cell. 2022. 10.1093/procel/pwac019/6645080.
4. Chen X, Wang P, Qiu H, Zhu Y, Zhang X, Zhang Y, Duan F, Ding S, Guo J, Huang Y, Na J. Integrative epigenomic and transcriptomic analysis reveals the requirement of JUNB for hematopoietic fate induction. Nature Communications, 2022, 13:3131, doi:10.1038/s41467-022-30789-4
5. Guo J, Wang P, Sozen B, Qiu H, Zhu Y, Zhang X, Ming J, Zernicka-Goetz M, Na J. Machine learning-assisted high-content analysis of pluripotent stem cell-derived embryos in vitro. Stem Cell Reports. 2021,16(5):1331-1346. doi: 10.1016/j.stemcr.2021.03.018.
6. Chen, B., Guo, J., Wang, T., Lee, Q., Ming, J., Ding, F., Li, H., Zhang, Z., Li, L., Cao, Y., and Na, J.* Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes. Protein Cell. 2021, 10.1007/s13238-021-00844-9.
7. Zhang F, Zhu Y, Chen J, Kuang W, Huang R, Duan F, Li Y, Wang L, Qiu H, Chen X, Ming J, Liu P, Du Y, Chang SC, Chen L, Na J. Efficient endothelial and smooth muscle cell differentiation from human pluripotent stem cells through a simplified insulin-free culture system. Biomaterials. 2021 Apr;271:120713. doi: 10.1016/j.biomaterials.2021.120713.
8. Wang L, Zhang F, Duan F, Huang R, Chen X, Ming J, Na J. Homozygous MESP1 knock-in reporter hESCs facilitated cardiovascular cell differentiation and myocardial infarction repair. Theranostics. 2020;10(15):6898-6914. doi: 10.7150/thno.42347.
9. Zhang J, Hirst A.J, Duan F, Qiu H, Huang R, Ji Y, Bai L, Zhang F, Robinson D, Jones M, … Na J. Anti-apoptotic Mutations Desensitize Human Pluripotent Stem Cells to Mitotic Stress and Enable Aneuploid Cell Survival. Stem Cell Reports. 2019, 12, 557-571. 10.1016/j.stemcr.2019.01.013.
10. Duan F, Huang R, Zhang F, Zhu Y, Wang L, Chen X, Bai L, Guo W, Chang SC, Hu X, and Na J. Biphasic modulation of insulin signaling enables highly efficient hematopoietic differentiation from human pluripotent stem cells. Stem Cell Research & Therapy 2018. 9, 205. 10.1186/s13287-018-0934-x.
11. Wu J, Xu J, Liu B, Yao G, Wang P, Lin Z, Huang B, Wang X, Li T, Shi S, …Na J*, Xie W* and Sun Y*. Chromatin analysis in human early development reveals epigenetic transition during ZGA. Nature 2018. 557:256-260. 10.1038/s41586-018-0080-8.
12. Li W, Wang P, Zhang B, Zhang J, Ming J, Xie W and Na J*. Differential regulation of H3S10 phosphorylation, mitosis progression and cell fate by Aurora Kinase B and C in mouse preimplantation embryos. Protein Cell. 2017, 9:662-674, doi:10.1007/s13238-017-0407-5.
13. Guo J, Ma D, Huang R, Ming J, Ye M, Kee K, Xie Z. and Na J* An inducible CRISPR-ON system for controllable gene activation in human pluripotent stem cells. Protein Cell 2017. 8, 379-393. 10.1007/s13238-016-0360-8.
14. Zhang F, Wang L, Li Y, Liu W, Duan F, Huang R, Chen X, Chang SC, Du Y, and Na J.* Optimizing mesoderm progenitor selection and three-dimensional microniche culture allows highly efficient endothelial differentiation and ischemic tissue repair from human pluripotent stem cells. Stem Cell Research & Therapy 2017. 8. 10.1186/s13287-016-0455-4.
15. Zhang B, Zheng H, Huang B, Li W, Xiang Y, Peng X, Ming J, Wu X, Zhang Y, Xu Q, Liu W, Kou X, Zhao Y, He W, Li C, Chen B, Li Y, Wang Q, Ma J, Yin Q, Kee K, Meng A, Gao S, Xu F, Na J* and Xie W*. 2016. Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature, 537:553-557. doi: 10.1038/nature19361
