Education:
2006-2010 B.S., Biological Sciences, Tsinghua University
2007-2010 B.A., Economics (Dual Degree), Tsinghua University
2010-2016 Ph.D., Cell and Molecular Biology, University of Pennsylvania
2010-2016 M.A., Statistics, University of Pennsylvania, The Wharton School
Professional Positions:
2016-2021 Postdoctoral Research Fellow, Memorial Sloan-Kettering Cancer Center
2021-Now Assistant Professor, School of Basic Medical Sciences, Tsinghua University
Research Areas:
The cellular metabolic network provides nutrient and energy that are fundamental to all biological processes. The laboratory of Dr. Jiajun Zhu at Tsinghua University aims to understand the principles of cellular metabolism that have the potential to improve treatment of cancer and age-related diseases. In the past decade, Dr. Zhu’s research has made important contribution to the field of cellular metabolism, including molecular characterization of how cells regulate amino acid metabolism in a subcellularly compartmentalized manner. Dr. Zhu’s research has culminated in a number of research articles published at journals such as Nature, Science, Cell Metabolism, Molecular Cell, and PNAS
Honors and Awards:
2022 “Tsinghua-Bayer” Investigator
2021 NSFC Excellent Young Scientist Fund (Overseas)
2020 NIH (NCI) Pathway to Independence (K99/R00) Award
2017 Leukemia & Lymphoma Society Postdoctoral Fellowship
2017 Life Sciences Research Foundation Postdoctoral Fellowship (declined)
2017 Susan G. Komen Postdoctoral Fellowship (declined)
2015 The Chinese Government Award for Outstanding Students Abroad
2010 First class prize for undergraduate student, Tsinghua University
2008 “Zheng Geru” Scholarship, School of Life Sciences, Tsinghua University
Selected Publications:
1.Zhen Z, Ren J, Zhu J#. The redox requirement and regulation during cell proliferation. Trends Endocrinol Metab. 2024
2.Zhu J# (co-correspondence), Wang H, Jiang X#. mTORC1 beyond anabolic metabolism: Regulation of cell death. J Cell Biol. 2022
3.Pavlova NN*, Zhu J* (equal contribution), Thompson CB. The hallmarks of cancer metabolism: Still emerging. Cell Metabolism. 2022.
4.Zhu J, Schwörer S, Berisa M, Kyung YJ, Ryu KW, Yi J, Jiang X, Cross JR, Thompson CB. Mitochondrial NADP(H) generation is essential for proline biosynthesis. Science. 2021.
5.Yi J*, Zhu J* (equal contribution), Wu J, Thompson CB, Jiang X. Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis. PNAS. 2020.
6.Zhu J, Thompson CB. Metabolic control of cell growth and proliferation. Nature Reviews Mol Cell Biol 2019.
7.Zhu J, Berisa M, Schwörer S, Qin W, Cross JR, Thompson CB. Transsulfuration activity can support cell growth upon extracellular cysteine limitation. Cell Metabolism. 2019.
8.Zhu J, Dou Z, Sammons MA, Levine AJ, Berger SL. Lysine methylation represses p53 activity in teratocarcinoma cancer cells. PNAS. 2016.
9.Sammons MA*, Zhu J* (equal contribution), Berger SL. A chromatin-focued siRNA screen for regulators of p53-dependent transcription. G3 (Genes Genomes Genetics). 2016.
10.Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, Barsyte-Lovejoy D, Al-awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature. 2015.
Complete list of publications:
https://scholar.google.com/citations?user=PYAk1M8AAAAJ&hl=en
